"Network Leaning" as a Mechanism of Insurmountable Antagonism of the Angiotensin II Type 1 Receptor by Non-peptide Antagonists

Journal of Biological Chemistry

Volumn 279, Issue 15, 2004, Pages 15248-15257

  Takezako, Takanobu ^a   Gogonea, Camelia ^a   Saad, Yasser ^a   Noda, Keita ^b   Karnik, Sadashiva S ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CONCENTRATION (PROCESS); CONFORMATIONS; DISSOCIATION; DRUG PRODUCTS; MUTAGENESIS;

CONFORMATIONAL TRANSITION; DISSOCIATION RATE;

BIOCHEMISTRY;

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CANDESARTAN; GLUTAMINE; LOSARTAN; MUTANT PROTEIN;

ARTICLE; CELL INTERACTION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; DRUG ANTAGONISM; DRUG MECHANISM; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BENZIMIDAZOLES; BINDING, COMPETITIVE; CELL MEMBRANE; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; KINETICS; LIGANDS; LOSARTAN; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDES; PROTEIN CONFORMATION; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; TEMPERATURE; TETRAZOLES; TIME FACTORS;

EID: 2442559346     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312728200     Document Type: Article

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