Inhibitory effect of disodium quercetin-7, 4'-disulfate on aggregation of pig platelets induced by thrombin and its mechanism

Acta Pharmacologica Sinica

Volumn 21, Issue 8, 2000, Pages 737-741

  Liu, W ^a   Liang, N C ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Actins; Blood platelets; Calcium; Flavones; Platelet aggregation; Protein kinase C; Quercetin

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATE; CALCIUM; CYTOSKELETON PROTEIN; DISODIUM QUERCETIN 7,4' DISULFATE; HISTONE; PROTEIN KINASE C; QUERCETIN DERIVATIVE; THROMBIN; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; NONHUMAN; SWINE; THROMBOCYTE AGGREGATION INHIBITION;

ACTINS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD PLATELETS; CALCIUM; FIBRINOLYTIC AGENTS; PLATELET AGGREGATION; PROTEIN KINASE C; QUERCETIN; SWINE;

EID: 0033899959     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Role of cyclic AMP in the inkibition of human platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin
2. On the mechanism of antithrombotic action of flavonoids
3. Differential effects of putative inhibitors on cytosolic and membrane associated platelet lipoxygenase
4. An investigation of functional similarities between the sarcoplasmic reticulum and platelet calcium-dependent adenosinetriphosphatases with the inhibitors quercetin and calmidazolium
5. Inhibition of tyrosine protein kinase activity by synthetic isoflavones and flavones
6. Preparation of water-soluble quercetin derivatives and their biological activities
7. Effects of temperature on preparation of quercetin sulphates
8. Study on effect of fuming sulfuric acid and quercetin
9. Inhibitory effects of sodium quercetin monosulfate on pig platelet aggregation induced by thrombin
10. Changes in the cytoskeletal structure of human platelets following thrombin activation
11. Cytosolic calcium in platelet activation
12. 2+ and protein kinase C is the major factor in determining the level of secretion from human platelets
13. Identification of membrane proteins mediating the interaction of human platelets
14. Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells
15. Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition