Evidence for hypothalamic KATP+ channels in the modulation of glucose homeostasis

European Journal of Pharmacology

Volumn 492, Issue 1, 2004, Pages 71-79

  Zhang, Yang ^a   Zhou, Jun ^b   Corll, Connie ^c   Porter, Johnnie R ^c   Martin, Roy J ^b   Roane, David S ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^c LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ATP sensitive K+ channel; Blood glucose; Glibenclamide; Hypoglycemic; Hypothalamus; Repaglinide

Indexed keywords

ADRENALIN; GLIBENCLAMIDE; GLUCAGON; GLUCOSE; INSULIN; NORADRENALIN; POTASSIUM CHANNEL; POTASSIUM ION; REPAGLINIDE;

ADRENALIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REGIMEN; FOOD INTAKE; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HYPOGLYCEMIA; HYPOTHALAMUS; IN VIVO CULTURE; INJECTION SITE; MALE; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD GLUCOSE; CARBAMATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPINEPHRINE; GLUCAGON; GLYBURIDE; HOMEOSTASIS; HYPOGLYCEMIC AGENTS; HYPOTHALAMUS; MALE; NOREPINEPHRINE; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 2442543342     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.03.040     Document Type: Article

References (42)

1. Amoroso S., Schmid-Antomarchi H., Fosset M., Lazdunski M. Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels. Science. 247:1990;852-854
2. Ashcroft F.M., Ashcroft S.J., Harrison D.E. Effects of 2-ketoisocaproate on insulin release and single potassium channel activity in dispersed rat pancreatic beta-cells. J. Physiol. 385:1987;517-529
3. Ashford M.L., Boden P.R., Treherne J.M. Tolbutamide excites rat glucoreceptive ventromedial hypothalamic neurones by indirect inhibition of ATP-K+ channels. Br. J. Pharmacol. 101:1990;531-540
4. Barg S., Renstrom E., Berggren P.O., Bertorello A., Bokvist K., Braun M., Eliasson L., Holmes W.E., Kohler M., Rorsman P., Thevenod F. The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein. Proc. Natl. Acad. Sci. U. S. A. 96:1999;5539-5544
5. Borg W.P., During M.J., Sherwin R.S., Borg M.A., Brines M.L., Shulman G.I. Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. J. Clin. Invest. 93:1994;1677-1682
6. Borg W.P., Sherwin R.S., During M.J., Borg M.A., Shulman G.I. Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes. 44:1995;180-184
7. Borg M.A., Sherwin R.S., Borg W.P., Tamborlane W.V., Shulman G.I. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J. Clin. Invest. 99:1997;361-365
8. Bounds J.K., Adloo A.A., Harp P.R., Olivier K., Roane D.S. The effect of centrally administered glibenclamide, tolbutamide and diazoxide on feeding in rats. Nutr. Neurosci. 2:1999;155-162
9. Dallaporta M., Perrin J., Orsini J.C. Involvement of adenosine triphosphate-sensitive K+ channels in glucose-sensing in the rat solitary tract nucleus. Neurosci. Lett. 278:2000;77-80
10. Dunn-Meynell A.A., Rawson N.E., Levin B.E. Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain. Brain Res. 814:1998;41-54
11. Eliasson L., Renstrom E., Ammala C., Berggren P.O., Bertorello A.M., Bokvist K., Chibalin A., Deeney J.T., Flatt P.R., Gabel J., Gromada J., Larsson O., Lindstrom P., Rhodes C.J., Rorsman P. PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells. Science. 271:1996;813-815
12. Ferreira M. Jr., Browning K.N., Sahibzada N., Verbalis J.G., Gillis R.A., Travagli R.A. Glucose effects on gastric motility and tone evoked from the rat dorsal vagal complex. J. Physiol. 536(Pt. 1):2001;141-152
13. Fuhlendorff J., Rorsman P., Kofod H., Brand C.L., Rolin B., MacKay P., Shymko R., Carr R.D. Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes. 47:1998;345-351
14. Fujii T., Inoue S., Nagai K., Nakagawa H. Involvement of adrenergic mechanism in hyperglycemia due to SCN stimulation. Horm. Metab. Res. 21:1989;643-645
15. Fujiwara T., Nagai K., Takagi S., Nakagawa H. Hyperglycemia induced by electrical stimulation of lateral part of dorsal parabrachial nucleus. Am. J. Physiol. 254(4 Pt. 1):1988;E468-E475
16. Funahashi H., Yada T., Muroya S., Takigawa M., Ryushi T., Horie S., Nakai Y., Shioda S. The effect of leptin on feeding-regulating neurons in the rat hypothalamus. Neurosci. Lett. 264:1999;117-120
17. Gromada J., Dissing S., Kofod H., Frokjaer-Jensen J. Effects of the hypoglycaemic drugs repaglinide and glibenclamide on ATP-sensitive potassium-channels and cytosolic calcium levels in beta TC3 cells and rat pancreatic beta cells. Diabetologia. 38:1995;1025-1032
18. Gromada J., Bokvist K., Hoy M., Olsen H.L., Lindstrom P., Hansen B.S., Gotfredsen C.F., Rorsman P., Thomsen M.K. Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis. Eur. J. Endocrinol. 147:2002;133-142
19. Ibrahim N., Bosch M.A., Smart J.L., Qiu J., Rubinstein M., Ronnekleiv O.K., Low M.J., Kelly M.J. Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels. Endocrinology. 144:2003;1331-1340
20. Jacob R.J., Fan X., Evans M.L., Dziura J., Sherwin R.S. Brain glucose levels are elevated in chronically hyperglycemic diabetic rats, no evidence for protective adaptation by the blood brain barrier. Metabolism. 51:2002;1522-1524
21. Karschin C., Ecke C., Ashcroft F.M., Karschin A. Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain. FEBS Lett. 401:1997;59-64
22. Lee K., Dixon A.K., Richardson P.J., Pinnock R.D. Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits. J. Physiol. 515:1999;439-452
23. Levin B.E., Dunn-Meynell A.A., Routh V.H. Brain glucose sensing and body energy homeostasis, role in obesity and diabetes. Am. J. Physiol. 276:1999;R1223-R1231
24. Lin C.Y., Higginbotham D.A., Judd R.L., White B.D. Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats. Am. J. Physiol. 282:2002;E1084-E1091
25. Luers C., Gardemann A., Miura H., Jungermann K. Neuropeptide Y and peptide YY, but not pancreatic polypeptide, substance P, cholecystokinin and gastric inhibitory polypeptide, inhibit the glucagon- and noradrenaline- dependent increase in glucose output in rat liver. Eur. J. Gastroenterol. Hepatol. 12:2000;455-462
26. Miki T., Liss B., Minami K., Shiuchi T., Saraya A., Kashima Y., Horiuchi M., Ashcroft F., Minokoshi Y., Roeper J., Seino S. ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat. Neurosci. 4:2001;507-512
27. Mobbs C.V., Kow L.M., Yang X.J. Brain glucose-sensing mechanisms, ubiquitous silencing by aglycemia vs. hypothalamic neuroendocrine responses. Am. J. Physiol. 281:2001;E649-E654
28. Morrison S.F. Differential control of sympathetic outflow. Am. J. Physiol. 281:2001;R683-R698
29. Muzumdar R., Ma X., Yang X., Atzmon G., Bernstein J., Karkanias G., Barzilai N. Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. FASEB J. 17:2003;1130-1132
30. Nichols C.G., Koster J.C. Diabetes and insulin secretion, whither KATP? Am. J. Physiol. 283:2002;E403-E412
31. Obici S., Feng Z., Tan J., Liu L., Karkanias G., Rossetti L. Central melanocortin receptors regulate insulin action. J. Clin. Invest. 108:2001;1079-1085
32. Obici S., Zhang B.B., Karkanias G., Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat. Med. 8:2002;1376-1382
33. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd edition:1986;Academic Press, New York
34. Renstrom E., Barg S., Thevenod F., Rorsman P. Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action. Diabetes. 51(Suppl. 1):2002;S33-S36
35. Roane D.S., Bounds J.K. ATP-sensitive K+ channels in the regulation of feeding: a hypothesis. Nutr. Neurosci. 2:1999;209-225
36. Roane D.S., Boyd N.E. Reduction of food intake and morphine analgesia by central glybenclamide. Pharmacol. Biochem. Behav. 46:1993;205-207
37. Schuit F.C., Huypens P., Heimberg H., Pipeleers D.G. Glucose sensing in pancreatic beta-cells, a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes. 50:2001;1-11
38. Silver I.A., Erecinska M. Extracellular glucose concentration in mammalian brain, continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. J. Neurosci. 14:1994;5068-5076
39. Spanswick D., Smith M.A., Groppi V.E., Logan S.D., Ashford M.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature. 390:1997;521-525
40. Spanswick D., Smith M.A., Mirshamsi S., Routh V.H., Ashford M.L. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat. Neurosci. 3:2000;757-758
41. Yang X.J., Kow L.M., Funabashi T., Mobbs C.V. Hypothalamic glucose sensor, similarities to and differences from pancreatic beta-cell mechanisms. Diabetes. 48:1999;1763-1772
42. Zhang Y., Roane D.S. Glibenclamide's action in the hypothalamus alters peripheral glucose homeostasis. Eur. J. Pharmacol. 424:2001;R1-R2