Folate levels and N 5, N 10-methylenetetrahydrofolate reductase genotype (MTHFR) in mothers of offspring with neural tube defects: A case-control study

Archives of Medical Research

Volumn 32, Issue 4, 2001, Pages 277-282

  de Villarreal, Laura E Martı�?nez ^a   Delgado Enciso, Iván ^a   Valdéz Leal, Ramón ^b   Ortı�?z López, Rocio ^a   Rojas Martı�?nez, Augusto ^a   Limón Benavides, Carmen ^a   Sánchez Peña, Marı�?a A ^a   Ancer Rodrı�?guez, Jesús ^a   Barrera Saldaña, Hugo A ^a   Villarreal Pérez, Jesús Z ^b  

^a Medicina UANL   (Mexico)

^b Estado de Nuevo León   (Mexico)

Author keywords

Folate levels; Methylenetetrahydrofolate reductase; Mexico; Neural tube defects

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; HOMOCYSTEINE; METHIONINE;

ARTICLE; BLOOD LEVEL; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; ERYTHROCYTE LEVEL; FEMALE; FOLIC ACID DEFICIENCY; GENE LOCUS; GENE MUTATION; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MEXICO; MOLECULAR GENETICS; MOTHER; NEURAL TUBE DEFECT; PROGENY; RISK FACTOR;

ADULT; ALLELES; AMINO ACID SUBSTITUTION; ANENCEPHALY; CASE-CONTROL STUDIES; CODON; DNA MUTATIONAL ANALYSIS; ERYTHROCYTES; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOCYSTEINE; HUMANS; INFANT, NEWBORN; MALE; MATERNAL-FETAL EXCHANGE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MEXICO; MUTATION, MISSENSE; NEURAL TUBE DEFECTS; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; RISK FACTORS; SPINAL DYSRAPHISM;

EID: 0034958324     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0188-4409(01)00292-2     Document Type: Article

References (42)

1. Neural tube defects; a review of human and animal studies on the etiology of neural tube defects
2. The embryonic development of mammalian neural tube defects
3. Genetic models
4. Maternal heat exposure and neural tube defects
5. Maternal use of antiepileptic drugs and the risk of major congenital malformations; a joint European prospective study of human teratogenesis associated with maternal epilepsy
6. VPA-induced neural tube defects in mice. I. Altered metabolism of sulfur-amino acids and glutathione
7. Studies in neural tube defects. I. Epidemiologic and etiologic aspects
8. The role of nutrition in neural tube defects
9. Neural tube defect etiology; new evidence concerning maternal hyperthermia, health and diet
10. Nutritional patterns of mothers of children with neural tube defects in Newfoundland
11. Prevention of neural-tube defects; results of the Medical Research Council Vitamin Study
12. Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR
13. A candidate genetic risk factor for vascular disease; a common mutation in the methylene tetrahydrofolate reductase
14. Periconceptional folic acid exposure and risk of occurrent neural tube defects
15. Preventing neural tube defects; the importance of periconceptional folic acid supplements
16. Elevated rates of neural tube defects in a high-prevalence area in northern China
17. Defectos congénitos y mortalidad infantil en el estado de Nuevo León
18. Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase; low folate status alone may be the critical factor
19. Mutated methylentetrahydrofolate reductase as a risk factor for spina bifida
20. 5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects
21. A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects
22. The 'thermolabile' variant of methylentetrahydrofolate reductase and neural defect; an evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother
23. Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects
24. A second common mutation in the methylenetetrahydrofolate reductase gene; an additional risk factor for neural-tube defects?
25. Methylenetetrahydrofolate reductase and neural tube defects
26. Relevance to spina bifida of mutated methylenetetrahydrofolate reductase
27. Screening of the C677T mutation on the methylenetetrahydrofolate reductase gene in French patients with neural tube defects
28. The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians
29. The C677T mutation of the 5,10-methylenetetrahydrofolate reductase gene is a moderate risk factor for spina bifida in Italy
30. Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida
31. Evaluation of the MTHFR C677T allele and the MTHFR gene locus in a German spina bifida population
32. Folate status, homocysteine metabolism, and methylenetetrahydrofolate reductase genotype in rural South African blacks with a history of pregnancy complicated by neural tube defects
33. Association of the 677C→T mutation on the methylenetetrahydrofolate reductase gene in Turkish patients with neural tube defects
34. High prevalence of the thermolabile methylenetetrahydrofolate reductase variant in Mexico; a country with a very high prevalence of neural tube defects
35. The C677T polymorphism of the methylenetetrahydrofolate reductase gene in Mexican mestizo neural-tube defect parents, control mestizo and native populations
36. Investigation of folate pathway gene polymorphisms and the incidence of neural tube defects in a Texas Hispanic population
37. Prevention of neural tube defects by and toxicity of L-homocysteine in culture postimplantation rat embryos
38. Homocysteine induces congenital defects of the heart and neural tube; effect of folic acid