Targeting ceramide by dietary means to stimulate apoptosis in tumor cells

Current Topics in Nutraceutical Research

Volumn 2, Issue 2, 2004, Pages 93-100

  Awad, Atif B ^a   Chinnam, Meenalakshmi ^a   Fink, Carol S ^a   Bradford, Peter G ^b  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

sitosterol; Apoptosis; Ceramide; Fatty acids; Phystosterols; Sphingolipids; Vitamins

Indexed keywords

20 EPI 22 ETHOXY 24A,26A,27A TRIHOMO 9,10 SECOCHOLESTA 5,7,10(19) TRIEN 23 YNE 1ALPHA,3BETA,25 TRIOL; CALCIPOTRIOL; CERAMIDE; COLECALCIFEROL; CORN OIL; FATTY ACID; FISH OIL; FLUOROURACIL; IRINOTECAN; PALMITIC ACID; PHYTOSTEROL; RETINOL; SITOSTEROL; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; TACALCITOL; VITAMIN D;

APOPTOSIS; BREAST CANCER; CANCER CELL CULTURE; COLON CANCER; DIET SUPPLEMENTATION; DRUG TARGETING; ENZYME ACTIVITY; FOOD COMPOSITION; FOOD INTAKE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPID METABOLISM; LIPOGENESIS; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; PROSTATE CANCER; RAT; REVIEW; TUMOR CELL;

EID: 2442475065     PISSN: 15407535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (58)

1. Andrieu-Abadie, N. and Levade, T. (2002) Sphingomyelin hydrolysis during apoptosis. Biochimica et Biophysica Acta 1585, 126-134.
2. Awad, A.B. and Fink, C.S. (2000) Phytosterols as anticancer dietary components: evidence and mechanism of action. Journal of Nutrition 130, 2127-2130.
3. Awad, A.B., Chen, Y.C., Fink, C.S. and Hennessey, T. (1996) beta-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids. Anticancer Research 16, 2797-2804.
4. Awad, A.B., Fink, C.S., Williams, H. and Kim, U. (2001) In vitro and in vivo (SCID mice) effects of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells. European Journal of Cancer Prevention 10, 507-513.
5. Awad, A.B., Roy, R. and Fink, C.S. (2003) Beta-sitosterol, a plant sterol, induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells. Oncology Reports 10, 497-500.
6. Bektas, M., Orfanos, C.E. and Geilen, C.C. (2000) Different vitamin D analogues induce sphingomyelin hydrolysis and apoptosis in the human keratinocyte cell line HaCaT. Cellular and Molecular Biology 46, 111-119.
7. Bertolaso, L., Gibellini, D., Secchiero, P., Previati, M., Falgione, D., Visani, G., Rizzoli, R., Capitani, S. and Zauli, G. (1998) Accumulation of catalytically active PKC-zeta into the nucleus of HL-60 cell line plays a key role in the induction of granulocytic differentiation mediated by all-trans retinoic acid. British Journal of Haematology 100, 541-549. Biochemical Journal 371, 243-256.
8. Birbes, H., Bawab, S.E., Obeid, L.M. and Hannun, Y.A. (2002) Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Advances in Enzyme Regulation 42, 113-129.
9. Cifone, M.G., Migliorati, G., Parroni, R., Marchetti, C., Millimaggi, D., Santoni, A. and Riccardi, C. (1999) Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases. Blood 93, 2282-2296.
10. Datta, R., Manome, Y., Taneja, N., Boise, L.H. Weichselbaum, R., Thompson, C.B., Slapak, C.A. and Kufe, D. (1995) Overexpression of Bcl-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation. Cell Growth & Differentiation 6, 363-367.
11. Fillet, M., Bentires-Alj, M., Deregowski, V., Greimers, R., Gielen, J., Bours, V. and Merville, M.P. (2003) Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity. Biochemical Pharmacology 65, 1633-1642.
12. Gomez-Munoz, A., Kong, J., Salh, B. and Steinbrecher, U.P. (2003) Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. FEBS Letters 539, 56-60.
13. Gulbins, E. and Grassme, H. (2002) Ceramide and cell death receptor clustering. Biochimica et Biophysica Acta 1585, 139-145.
14. Hannun, Y.A. (1994) The sphingomyelin cycle and the second messenger function of ceramide. Journal of Biological Chemistry 269, 3125-3128.
15. Hannun, Y.A. and Luberto, C. (2000) Ceramide in the eukaryotic stress response. Trends in Cell Biology 10, 73-80.
16. Hannun, Y.A. and Obeid, L.M. (1997) Mechanisms of ceramide-mediated apoptosis. Advances in Experimental Medicine & Biology 407, 145-149.
17. Hardy, S., El-Assaad, W., Przybytkowski, E., Joly, E., Prentki, M. and Langelier, Y. (2003) Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin. Journal of Biological Chemistry 278, 31861-31870.
18. Hospattankar, A.V., Vunnam, R.R. and Radin, N.S. (1982) Changes in liver lipids after administration of 2-decanoylamino-3-morpholinopropiophenone and chlorpromazine. Lipids 17, 538-543.
19. Huwiler, A., Kolter, T., Pfeilschifter, J. and Sandhoff, K. (2000) Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochimica et Biophysica Acta 1485, 63-99.
20. Jayadev, S., Liu, B., Bielawska, A.E., Lee, J.Y., Nazaire, F., Pushkareva, M.Yu., Obeid, L.M. and Hannun, Y.A. (1995) Role for ceramide in cell cycle arrest. Journal of Biological Chemistry 270, 2047-2052.
21. Jiang, Y.H., Lupton, J.R., Chang, W.C., Jolly, C.A., Aukema, H.M. and Chapkin, R.S. (1996) Dietary fat and fiber differentially alter intracellular second messengers during tumor development in rat colon. Carcinogenesis 17, 1227-1233.
22. Kashiwagi, K., Shirai, Y., Kuriyama, M., Sakai, M. and Saito, N. (2002) Importance of C1B domain for lipid messenger-induced targeting of protein kinase C. Journal of Biological Chemistry 277, 18037-18045.
23. Kalen, A., Borchardt, R.A. and Bell, R.M. (1992) Elevated ceramide levels in GH4C1 cells treated with retinoic acid. Biochimica et Biophysica Acta 1125, 90-96.
24. Kolesnick, R., (2002) The therapeutic potential of modulating the ceramide/sphingomyelin pathway. Journal of Clinical Investigation 110, 3-8.
25. Li, J.H., Awad, A.B., Fink, C.S., Wu, Y.W., Trevisan,, M. and Muti, P. (2001) Measurement variability of plasma beta-sitosterol and campesterol, two new biomarkers for cancer prevention. European Journal of Cancer Prevention 10, 245-249.
26. Ling, W.H. and Jones, P.J. (1995) Dietary phytosterols: a review of metabolism, benefits and side effects. Life Sciences 57, 195-206.
27. Listenberger, L.L., Ory, D.S. and Schaffer, J.E. (2001) Palmitate-induced apoptosis can occur through a ceramide-independent pathway. Journal of Biological Chemistry 276, 14890-14895.
28. Liu, J.J., Nilsson, A. and Duan, R.D. (2002) In vitro effects of fat, FA, and cholesterol on sphingomyelin hydrolysis induced by rat intestinal alkaline sphingomyelinase. Lipids 37, 469-474.
29. Lu, Z.H., Mu, Y.M., Wang, B.A., Li, X.L., Lu, J.M., Li, J.Y., Pan, C.Y., Yanase, T. and Nawata, H. (2003) Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cell. Biochemical and Biophysical Research Communications 303, 1002-1007.
30. Luberto, C., Kraveka, J.M. and Hannun, Y.A. (2002) Ceramide regulation of apoptosis versus differentiation: a walk on a fine line. Lessons from neurobiology. Neurochemical Research 27, 609-617.
31. Maceyka, M., Payne, S.G., Milstien, S. and Spiege,I S. (2002) Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochimica et Biophysica Acta 1585, 193-201.
32. Magrassi, L., Adorni, L., Montorfano, G., Rapelli, S., Butti, G., Berra, B. and Milanesi, G. (1998) Vitamin D metabolites activate the sphingomyelin pathway and induce death of glioblastoma cells. Acta Neurochirurgica 140, 707-714.
33. Mathias, S., Pena, L.A. and Kolesnick, R.N. (1998) Signal transduction of stress via ceramide. Biochemical journal 335, 465-480.
34. Maziere, C., Conte, M.A., Leborgne, L., Levade, T., Hornebeck, W., Santus, R. and Maziere, J.C. (2001) UVA radiation stimulates ceramide production: relationship to oxidative stress and potential role in ERK, JNK, and p38 activation. Biochemical & Biophysical Research Communications 281, 289-294.
35. Mimeault, M. (2002) New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer. FEBS Letters 530, 9-16.
36. Modrak, D.E., Rodriguez, M.D., Goldenberg, D.M. and Lew, W. and Blumenthal, R.D. (2002) Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts. International Journal of Oncology 20, 379-384.
37. Mu, Y.M., Yanase, T., Nishi, Y., Tanaka, A., Saito, M., Jin, C.H., Mukasa, C., Okabe, T., Nomura, M., Goto, K. and Nawata, H. (2001) Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells. Endocrinology 142, 3590-3597.
38. Muti, P., Awad, A.B., Schunemann, H., Fink, C.S., Hovey, K., Freudenheim, J.L., Wu, Y.B., Bellati, C. Pala, V. and Berrino, F. (2003) A plant food-based diet modifies the serum b-sitosterol concentration in hypeandrogenic postmenopausal women. Journal of Nutrition 133, 4252-4255.
39. Myrick, D., Blackinton, D., Klostergaard, J., Kouttab, N., Maizel, A., Wanebo, H. and Mehta, S. (1999) Paclitaxel-induced apoptosis in Jurkat, a leukemic T cell line, is enhanced by ceramide. Leukemia Research 23, 569-578.
40. Okazaki, T., Kondo, T., Kitano, T. and Tashima, M. (1998) Diversity and complexity of ceramide signalling in apoptosis. Cellular Signalling 10, 685-692.
41. Pettus, B.J., Chalfan,t C.E., and Hannun, Y.A.(2002) Ceramide in apoptosis: an overview and current perspectives. Biochimica et Biophysica Acta 1585, 114-125.
42. Phillips, D.C., Allen, K. and Griffiths, H.R. (2002) Synthetic ceramides induce growth arrest by altering cellular redox status. Archives of Biochemistry & Biophysics 407, 15-24.
43. Pirianov, G. and Colston, K.W. (2001) Interactions of vitamin D analogue CB1093, TNFalpha and ceramide on breast cancer cell apoptosis. Molecular and Cellular Endocrinology 172, 69-78.
44. Ponec M. Weerheim A. Kempenaar J. Mulder A. Gooris GS. Bouwstra J. Mommaas AM. The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C. Journal of Investigative Dermatology. 109(3):348-55, 1997.
45. Pushkareva, M., Obeid, L.M. and Hannun, Y.A. (1995) Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunology Today 16, 294-297.
46. Radin, N.S. (2003) Killing tumours by ceramide-induced apoptosis: a critique of available drugs. Biochemical Journal 371, 243-256.
47. Radin, N.S., Shayman, J.A. and Inokuchi, J. (1993) Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances. Advances in Lipid Research. 26, 183-213.
48. Schmelz, E.M., Dillehay, D.L., Webb, S.K., Reiter, A., Adams, J. and Merrill, A.H. Jr. (1996) Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: implications for dietary sphingolipids and colon carcinogenesis. Cancer Research 56, 4936-4941.
49. Schmelz, E.M., Sullards, M.C., Dillehay, D.L. and Merrill, A.H Jr. (2000) Colonic cell proliferation and aberrant crypt foci formation are inhibited by dairy glycosphingolipids in 1, 2-dimethylhydrazine-treated CF1 mice. Journal of Nutrition 130, 522-527.
50. Senchenkov, A., Litvak, D.A., Cabot, M.C. (2001) Targeting ceramide metabolism - a strategy for overcoming drug resistance. Journal of the National Cancer Institute 93, 347-357.
51. Spiegel, S. and Milstien, S. (2002) Sphingosine 1-phosphate, a key cell signaling molecule. Journal of Biological Chemistry 277, 25851-25854.
52. Strum, J.C., Small, G.W., Pauig, S.B. and Daniel, L.W. (1994) 1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells. Journal of Biological Chemistry. 269, 15493-154977.
53. van Blitterswijk, W.J., van der Luit, A.H., Veldman, R.J., Verheij, M., Borst, J. (2003) Ceramide: second messenger or modulator of membrane structure and dynamics? Biochemical Journal 369, 199-211.
54. Venable, M.E., Lee, J.Y., Smyth, M.J., Bielawska, A. and Obeid, L.M. (1995) Role of ceramide in cellular senescence. Journal of Biological Chemistry 270, 30701-30708.
55. Vesper, H., Schmelz, E.M., Nikolova-Karakashian, M.N., Dillehay, D.L., Lynch, D.V. and Merrill AH Jr. (1999) Sphingolipids in food and the emerging importance of sphingolipids to nutrition. Journal of Nutrition 129, 1239-1250.
56. von Holtz, R.L., Fink, C.S. and Awad, A.B. (1998) beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells. Nutrition and Cancer 32, 8-12.
57. Weststrate, J.A. and Meijer, G.W. (1998) Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. European Journal of Clinical Nutrition 52, 334-343.
58. Wu, D., Marko, M., Claycombe, K., Paulson, K.E. and Meydani, S.N. (2003) Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappaB activity. Journal of Biological Chemistry 278, 10983-10992.