Interactions of vitamin D analogue CB1093, TNFα and ceramide on breast cancer cell apoptosis

Molecular and Cellular Endocrinology

Volumn 172, Issue 1-2, 2001, Pages 69-78

  Pirianov, G ^a   Colston, K W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; Ceramide; cPLA2; Human breast cancer cells; TNF ; Vitamin D analogues

Indexed keywords

20 EPI 22 ETHOXY 24A,26A,27A TRIHOMO 9,10 SECOCHOLESTA 5,7,10(19) TRIEN 23 YNE 1ALPHA,3BETA,25 TRIOL; ARACHIDONIC ACID; ARACHIDONYL TRIFLUOROMETHYL KETONE; CASPASE INHIBITOR; CERAMIDE; DNA FRAGMENT; N BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; Z VAD FMK;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL DEATH; CELL STRAIN MCF 7; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEDIATOR; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CALCITRIOL; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME ACTIVATION; FEMALE; HUMANS; PHOSPHOLIPASES A; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035857473     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(00)00380-4     Document Type: Article

References (33)

1. Vitamin D: a calciotropic hormone regulating calcium-induced keratinocyte differentiation
2. Development of new vitamin D analogs
3. Structure function relationships in the vitamin D endocrine system
4. Alteration of the sphingomyelin/ceramide pathway is associated with resistance of MCF-7 cells to TNFα-mediated cytotoxicity
5. Cell killing and induction of manganous superoxide dismutase by tumor necrosis factor-alpha is mediated by lipoxygenase metabolites of arachidonic acid
6. FADD, a novel death domain-containing protein, interacts with the death domain of FAS and initiates apoptosis
7. Vitamin D and breast cancer: therapeutic potential of new vitamin D analogs
8. EB1089: a new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro
9. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture
10. 3 analogue is related to promoter selectivity
11. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to TNFα: CrmA and Bcl-2 target distinct components in the apoptotic pathway
12. 3 analogues; a novel class of potent inhibitors of proliferation and inducers of differentiation of breast cancer cell lines
13. The nuclear vitamin D receptor: biological and molecular regulatory properties revealed
14. Vitamin D derivatives in combination with 9-cis retinoic acid promote active cell death in breast cancer cells
15. Ceramide induces caspase-independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis
16. 2 isoforms are altered in chronic pancreatitis
17. 2 by caspase-l (ICE) and caspase-8 (FLICE)
18. EB1089, a novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cells
19. Program cell death induced by ceramide
20. Potentiation by vitamin D analogs of TNFα and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2
21. The role of calcium and phosphorylation of cytosolic phospholipase
22. 3 potentiates the cytotoxic effect of TNFa on human breast cancer cells
23. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha
24. Molecular cloning and expression of a receptor for human tumor necrosis factor
25. 3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells
26. Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways
27. A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins
28. 2 in human melanoma tumor cells
29. 3 and antiestrogens in modulating apoptosis of breast cancer cells and tumors
30. Functional dichotomy of neutral and acidic sphingomyelinases in TNF signalling
31. 2 in tumor necrosis factor-induced apoptosis
32. 2