Loss of EPC-1/PEDF expression during skin aging in vivo

Journal of Investigative Dermatology

Volumn 122, Issue 5, 2004, Pages 1096-1105

  Francis, Mary Kay ^a,b   Appel, Stacia ^a   Meyer, Christine ^a   Balin, Samuel J ^a   Balin, Arthur K ^a,c   Cristofalo, Vincent J ^a,b  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c Sally Balin Medical Center   (United States)

Author keywords

Angiogenesis inhibitor; EPC 1; Gene expression in vivo; PEDF; Skin aging

Indexed keywords

ANGIOGENESIS INHIBITOR; ANGIOGENIC FACTOR; MESSENGER RNA; PIGMENT EPITHELIUM DERIVED FACTOR; PROTEOHEPARAN SULFATE; THROMBOSPONDIN 1; VASCULOTROPIN;

ADOLESCENT; ADULT; AGED; AGING; ANGIOGENESIS; ARTICLE; BASEMENT MEMBRANE; BLOOD VESSEL; CELL COUNT; CELL DENSITY; CELL LEVEL; CELL NUCLEUS; CONTROLLED STUDY; CUTANEOUS PARAMETERS; DERMIS; DERMOEPIDERMAL JUNCTION; DOWN REGULATION; EPIDERMIS; GENE EXPRESSION; GENOMIC IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; LUNG FIBROBLAST; MICROVASCULARIZATION; MICROVASCULATURE; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EID: 2442464644     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.22510.x     Document Type: Article

References (56)

1. Alberdi E, Aymerich MS, Becerra SP: Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor. J Biol Chem 274:31605-31612, 1999
2. Alberdi EM, Weldon JE, Becerra SP: Glycosaminoglycans in human retinoblastoma cells: Heparan sulfate, a modulator of the pigment epithelium-derived factor-receptor interactions. BMC Biochem 4:1, 2003
3. Andrew W, Behnke R, Sato T: Changes with advancing age in the cell population of human dermis. Gerontologica 10:1-19, 1964
4. Araki T, Taniwaki T, Becerra SP, Chader GJ, Schwartz JP: Pigment epithelium-derived factor (PEDF) differentially protects immature but not mature cerebellar granule cells against apoptotic cell death. J Neurosci Res 53:7-15, 1998
5. Aymerich MS, Alberdi EM, Martinez A, Becerra SP: Evidence for pigment epithelium-derived factor receptors in the neural retina. Invest Ophthalmol Vis Sci 42:3287-3293, 2001
6. Balin AK, Lin AN: Skin changes as a biological marker for measuring the rate of human aging. In: Balin AK, Kligman AM (eds). Aging and the Skin. New York: Raven Press, 1989; p 43-75
7. Becerra SP, Palmer I, Kumar A, Steele F, Shiloach J, Notario V, Chader GJ: Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor. J Biol Chem 268:23148-23156, 1993
8. Bielenberg DR, Bucana CD, Sanchez R, Donawho CK, Kripke ML, Fidler IJ: Molecular regulation of UVB-induced cutaneous angiogenesis. J Invest Dermatol 111:864-872, 1998
9. Bilak MM, Becerra SP, Vincent AM, Moss BH, Aymerich MS, Kuncl RW: Identification of the neuroprotective molecular region of pigment epithelium-derived factor and its binding sites on motor neurons. J Neurosci 22:9378-9386, 2002
10. Black M: A modified radiographic method for measuring skin thickness. Br J Dermatol 81:661-666, 1969
11. Cao W, Tombran-Tink J, Chen W, Mrazek D, Elias R, McGinnis JF: Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death. J Neurosci Res 57:789-800, 1999
12. Cao W, Tombran-Tink J, Elias R, Sezate S, Mrazek D, McGinnis JF: In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor. Invest Ophthalmol Vis Sci 42:1646-3293, 2001
13. Cristofalo VJ, Allen RG, Pignolo RJ, Martin BG, Beck JC: Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation. Proc Natl Acad Sci USA 95:10614-10619, 1998a
14. Cristofalo VJ, Volker C, Francis MK, Tresini M: Age-dependent modifications of gene expression in human fibroblasts. Crit Rev Eukaryot Gene Expr 8:43-80, 1998b
15. Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W, Bouck NP: Pigment epithelium-derived factor: A potent inhibitor of angiogenesis. Science 285:245-248, 1999
16. DeCoster MA, Schabelman E, Tombran-Tink J, Bazan NG: Neuroprotection by pigment epithelial-derived factor against glutamate toxicity in developing primary hippocampal neurons. J Neurosci Res 56:604-810, 1999
17. Detmar M: Tumor angiogenesis. J Investig Dermatol Symp Proc 5:20-23, 2000
18. Doggett DL, Rotenberg MO, Pignolo RJ, Phillips PD, Cristofalo VJ: Differential gene expression between young and senescent, quiescent WI-38 cells. Mech Ageing Dev 65:239-255, 1992
19. Doll JA, Stellmach VM, Bouck NP, et al: Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. Nat Med 12:12, 2003
20. Holekamp NM, Bouck N, Volpert O: Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration. Am J Ophthalmol 134:220-227, 2002
21. Kishimoto J, Ehama R, Ge Y, Kobayashi T, Nishiyama T, Detmar M, Burgeson RE: In vivo detection of human vascular endothelial growth factor promoter activity in transgenic mouse skin. Am J Pathol 157:103-110, 2000
22. Kozaki K, Miyaishi O, Koiwai O, et al: Isolation, purification, and characterization of a collagen-associated serpin, caspin, produced by murine colon adenocarcinoma cells. J Biol Chem 273:15125-15130, 1998
23. Li W, Yanoff M, Li Y, He Z: Artificial senescence of bovine retinal pigment epithelial cells induced by near-ultraviolet in vitro. Mech Ageing Dev 110:137-155, 1999
24. Montagna W, Carlisle K: Structural changes in aging human skin. J Invest Dermatol 73:47-53, 1979
25. Ogata N, Nishikawa M, Nishimura T, Mitsuma Y, Matsumura M: Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am J Ophthalmol 134:348-353, 2002
26. Ohno-Matsui K, Morita IT, ombran-Tink J, et al: Novel mechanism for age-related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF. J Cell Physiol 189:323-333, 2001
27. Okun MR, Edelstein LM, Fisher BK: Gross and Microscopic Pathology of the Skin. Canton, MA: Dermatopathology Foundation Press, 1988; p 14-49
28. Palmien D, Watson JM, Rinehart CA: Age-related expression of PEDF/EPC-1 in human endometrial stromal fibroblasts: Implications for interactive senescence. Exp Cell Res 247:142-147, 1999
29. Pignolo RJ, Cristofalo VJ, Rotenberg MO: Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the GO state. J Biol Chem 268:8949-8957, 1993
30. Pignolo RJ, Francis MK, Rotenberg MO, Cristofalo VJ: Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts. J Cell Physiol 195:12-20, 2003
31. Pignolo RJ, Rotenberg MO, Cristofalo VJ: Analysis of EPC-1 growth state-dependent expression, specificity, and conservation of related sequences. J Cell Physiol 162:110-118, 1995
32. Pili R, Guo Y, Chang J, Nakanishi H, Martin GR, Passaniti A: Altered angiogenesis underlying age-dependent changes in tumor growth. J Natl Cancer Inst 86:1303-1314, 1994
33. Rasmussen H, Chu KW, Campochiaro P: Clinical protocol. An open-label, phase I, single administration, dose- escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD). Hum Gene Ther 12:2029-2032, 2001
34. Rivard A, Fabre JE, Silver M, et al: Age-dependent impairment of angiogenesis. Circulation 99:111-120, 1999
35. Ryan TJ: The epidermis and its blood supply in venous disorders of the leg. Trans St Johns Hosp Dermatol Soc 55:51-63, 1969
36. Sadoun E, Reed MJ: Impaired angiogenesis in aging is associated with alterations in vessel density, matrix composition, inflammatory response, and growth factor expression. J Histochem Cytochem 51:1119-1130, 2003
37. Sauer GC, Hall JC: Manual of Skin Diseases. Philadelphia: Lippincott-Raven Publishers, 1996; p 1-8
38. Seigel GM, Tombran-Tink J, Becerra SP, et al: Differentiation of Y79 retinoblastoma cells with pigment epithelial- derived factor and interphotoreceptor matrix wash: Effects on tumorigenicity. Growth Factors 10:289-297, 1994
39. Semkova I, Kreppel F, Welsandt G, et al: Autologous transplantation of genetically modified iris pigment epithelial cells: A promising concept for the treatment of age-related macular degeneration and other disorders of the eye. Proc Natl Acad Sci USA 99:13090-13095, 2002
40. Shirozu M, Tada H, Tashiro K, et al: Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics 37:273-280, 1996
41. Spranger J, Osterhoff M, Reimann M, et al: Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. Diabetes 50:2641-2645, 2001
42. Steele FR, Chader GJ, Johnson LV, Tombran-Tink J: Pigment epithelium-derived factor: Neurotrophic activity and identification as a member of the serine protease inhibitor gene family. Proc Natl Acad Sci USA 90:1526-1530, 1993
43. Stratikos E, Alberdi E, Gettins PG, Becerra SP: Recombinant human pigment epithelium-derived factor (PEDF): Characterization of PEDF overexpressed and secreted by eukaryotic cells. Protein Sci 5:2575-2582, 1996
44. Swift ME, Kleinman HK, DiPietro LA: Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest 79:1479-1487, 1999
45. Taniwaki T, Becerra SP, Chader GJ, Schwartz JP: Pigment epithelium-derived factor is a survival factor for cerebellar granule cells in culture. J Neurochem 64:2509-2517, 1995
46. Taniwaki T, Hirashima N, Becerra SP, Chader GJ, Etcheberrigaray R, Schwartz JP: Pigment epithelium-derived factor protects cultured cerebellar granule cells against glutamate-induced neurotoxicity. J Neurochem 68:26-32, 1997
47. Tombran-Tink J, Chader GG, Johnson LV: PEDF: A pigment epithelium-derived factor with potent neuronal differentiative activity. Exp Eye Res 53:411-414, 1991
48. Tombran-Tink J, Mazuruk K, Rodriguez IR, Chung D, Linker T, Englander E, Chader GJ: Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin. Mol Vis 2:11, 1996
49. Tombran-Tink J, Shivaram SM, Chader GJ, Johnson LV, Bok D: Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity. J Neurosci 15:4992-5003, 1995
50. Tresini M, Pignolo RJ, Allen RG, Cristofalo VJ: Effects of donor age on the expression of a marker of replicative senescence (EPC-1) in human dermal fibroblasts. J Cell Physiol 179:11-17, 1999
51. Tsuchida Y: The effect of aging and arteriosclerosis on human skin blood flow. J Dermatol Sci 5:175-181, 1993
52. Weninger W, Uthman A, Pammer J, et al: Vascular endothelial growth factor production in normal epidermis and in benign and malignant epithelial skin tumors. Lab Invest 75:647-657, 1996
53. Wight TN, Raugi GJ, Mumby SM, Bornstein P: Light microscopic immunolocation of thrombospondin in human tissues. J Histochem Cytochem 33:295-302, 1985
54. Yabe T, Wilson D, Schwartz JP: NFkappaB activation is required for the neuroprotective effects of pigment epithelium-derived factor (PEDF) on cerebellar granule neurons. J Biol Chem 276:43313-43319, 2001
55. Yamagishi S, Inagaki Y, Amano S, Okamoto T, Takeuchi M, Makita Z: Pigment epithelium-derived factor protects cultured retinal pericytes from advanced glycation end product-induced injury through its antioxidative properties. Biochem Biophys Res Commun 296:877-882, 2002
56. Yamaura H, Matsuzawa T: Decrease in capillary growth during aging. Exp Gerontol 15:145-150, 1980