A combined in vivo pharmacokinetic-in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans

Journal of Antimicrobial Chemotherapy

Volumn 46, Issue 5, 2000, Pages 733-739

  Delacher, Simon ^a   Derendorf, Hartmut ^d   Hollenstein, Ursula ^b   Brunner, Martin ^a   Joukhadar, Christian ^a   Hofmann, Sabine ^c   Georgopoulos, Apostoulos ^b   Eichler, Hans Georg ^a   Müller, Markus ^a  

^a Department of Clinical Pharmacology   (Austria)

^b Division of Infectious Diseases   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CIPROFLOXACIN;

ANTIMICROBIAL THERAPY; AREA UNDER THE CURVE; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM ISOLATE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BINDING; DRUG EXPOSURE; DRUG TARGETING; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; INTERSTITIAL FLUID; MALE; MICRODIALYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NORMAL HUMAN; PSEUDOMONAS AERUGINOSA; SIMULATION;

EID: 0033736006     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/46.5.733     Document Type: Article

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