Distribution of metronidazole in muscle tissue of patients with septic shock and its efficacy against Bacteroides fragilis in vitro

Journal of Antimicrobial Chemotherapy

Volumn 55, Issue 3, 2005, Pages 341-346

  Karjagin, Juri ^a   Pähkla, Rein ^a   Karki, Tõnis ^a   Starkopf, Joel ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

Microdialysis; Pharmacodynamics; Pharmacokinetics

Indexed keywords

METRONIDAZOLE;

ADULT; AGED; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTEROIDES FRAGILIS; BIOLOGICAL MODEL; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG TISSUE LEVEL; ERADICATION THERAPY; HOSPITAL ADMISSION; HUMAN; IN VITRO STUDY; INTENSIVE CARE UNIT; MALE; MICRODIALYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACODYNAMICS; SEPTIC SHOCK; SINGLE DRUG DOSE;

ADULT; AGED; AREA UNDER CURVE; BACTEROIDES FRAGILIS; HUMANS; MALE; METRONIDAZOLE; MICRODIALYSIS; MIDDLE AGED; MUSCLES; SHOCK, SEPTIC;

EID: 15844383635     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh544     Document Type: Article

References (20)

1. Friedman, G., Silva, E. & Vincent, J. L. (1998). Has the mortality of septic shock changed with time? Critical Care Medicine 26, 2078-86.
2. Rivers, E., Nguyen, B., Havstad, S. et al. (2001). Early goal-directed therapy in the treatment of severe sepsis and septic shock. New England Journal of Medicine 345, 1368-77.
3. Müller, M., Haag, O., Burgdorff, T. et al. (1996). Characterization of peripheral compartment kinetics of antibiotics by in vivo microdialysis in humans. Antimicrobial Agents and Chemotherapy 40, 2703-9.
4. Joukhadar, C., Frossard, M., Mayer, B. X. et al. (2001). Impaired target site penetration of β-lactams may account for therapeutic failure in patients with septic shock. Critical Care Medicine 29, 385-91.
5. Joukhadar, C., Klein, N., Mayer, B. X. et al. (2002). Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis. Critical Care Medicine 30, 1478-82.
6. Zeitlinger, M. A., Dehghanyar, P., Mayer, B. X. et al. (2003). Relevance of soft-tissue penetration by levofloxacin for target site bacterial killing in patients with sepsis. Antimicrobial Agents and Chemotherapy 47, 3548-53.
7. FDA-CDER (1997). Guidance for Industry - Evaluating Clinical Studies of Antimicrobials in the Division of Anti-Infective Drug Products. U.S. Food and Drug Administration, Rockville, MD, USA.
8. Liu, P., Müller, M. & Derendorf, H. (2002). Rational dosing of, antibiotics: the use of plasma concentrations versus tissue concentrations. International Journal of Antimicrobial Agents 19 285-90.
9. Sauermann, R., Zeitlinger, M., Erovic, B. M. et al. (2003). Pharmacodynamics of piperacillin in severely ill patients evaluated by using a PK/PD model. International Journal of Antimicrobial Agents 22, 574-8.
10. Lamp, K., Freeman, C. D., Klutman, N. E. et al. (1999). Pharmacokinetics and pharmacodynamics of nitroimidazole antimicrobials. Clinical Pharmacokinetics 36, 353-73.
11. Kling, P. & Burman, L. G. (1989). Serum and tissue pharmacokinetics of intravenous metronidazole in surgical patients. Acta Chirurgica Scandinavica 155, 347-50.
12. Plaisance, K. I., Quintiliani, R. & Nightingale, C. H. (1988). The pharmacokinetics of metronidazole and its metabolites in critically ill patients. Journal of Antimicrobial Chemotherapy 21, 195-200.
13. Karjagin, J., Pähkla, R. & Starkopf, J. (2004). Perioperative penetration of metronidazole into muscle tissue: a microdialysis study. European Journal of Clinical Pharmacology 59, 809-13.
14. Bone, R. C., Sibbald, W. J., Cerra, F. B. et al. (1992). Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101, 1644-55.
15. Ståhle, L., Segersvärd, S. & Ungerstedt, U. (1991). A comparison between three methods for estimation of extracellular concentrations of exogenous and endogenous compounds by microdialysis. Journal of Pharmacological Methods 25, 41-52.
16. Hardman, J. G. & Limbird, L. E. (1996). Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th edn. McGraw-Hill, New York, NY, USA.
17. Klimowicz, A., Nowak, A. & Bielecka-Grzela, S. (1996). Plasma and skin blister fluid concentration of metronidazole and its hydroxymetabolite after oral administration. Polish Journal of Pharmacology 48, 47-52.
18. Bielecka-Grzela, S. & Klimowicz, A. (2003). Application of cutaneous microdialysis to evaluate metronidazole and its main metabolite concentrations in the skin after a single oral dose. Journal of Clinical Pharmacy and Therapeutics 28, 465-9.
19. Mandell, G. L., Douglas, R. G. & Bennet, J. E. (1990). Principles and Practice of Infectious Diseases, 3rd edn. Churchill Livingstone, New York, NY, USA.
20. Lewis, R. E., Klepser, M. E., Ernst, E. J. et al. (2000). Comparison of oral immediate-release (IR) and extended-release (ER) metronidazole bactericidal activity against Bacteroides spp. using an in vitro model of infection. Diagnostic Microbiology and Infectious Disease 37, 51-5.