Penetration of meropenem into pneumonic human lung tissue as measured by in vivo microdialysis

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 6, 2004, Pages 2228-2232

  Tomaselli, Florian ^a   Maier, Alfred ^b   Matzi, Veronika ^b   Smolle Jüttner, Freyja Maria ^b   Dittrich, Peter ^c  

^a Department of Surgery   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

MEROPENEM;

ADULT; AGED; ARTICLE; BACTERIUM; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DECORTICATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG PENETRATION; DRUG TISSUE LEVEL; EXTRACELLULAR SPACE; FEMALE; HUMAN; IN VIVO STUDY; INTRAOPERATIVE PERIOD; LUNG PARENCHYMA; LUNG SURGERY; MALE; MICRODIALYSIS; PLEURA EMPYEMA; PNEUMONIA; PRIORITY JOURNAL; SERUM; SKELETAL MUSCLE;

ADULT; AGED; AREA UNDER CURVE; FEMALE; HALF-LIFE; HUMANS; INJECTIONS, INTRAVENOUS; LUNG; MALE; MICRODIALYSIS; MIDDLE AGED; MUSCLE, SKELETAL; PNEUMONIA; THIENAMYCINS;

EID: 2542443541     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.6.2228-2232.2004     Document Type: Article

References (39)

1. Ali, I., and H. Unruh. 1990. Management of empyema thoracis. Ann. Thorac. Surg. 55:355-359.
2. Alvarez Lerma, F. 2001. Efficacy of meropenem as monotherapy in the treatment of ventilator-associated pneumonia. J. Chemother. 13:70-81.
3. Baldwin, D. R., D. Honeybourne, and R. Wise. 1992. Pulmonary disposition of antimicrobial agents: in vivo observations and clinical relevance. Antimicrob. Agents Chemother. 36:1176-1180.
4. Baldwin, D. R., D. Honeybourne, and R. Wise. 1992. Pulmonary disposition of antimicrobial agents: methodological considerations. Antimicrob. Agents Chemother. 36:1171-1175.
5. Bergeron, M. G. 1990. The changing bacterial spectrum and antibiotic choice, p. 197. In J. Deslaurier and L. K. Lacyuet (ed.), International trends in general thoracic surgery, vol. 6. The C.V. Mosby Co., St. Louis, Mo.
6. Bergogne-Berezin, E. 1981. Penetration of antibiotics into the respiratory tree. J. Antimicrob. Chemother. 8:171-174.
7. Bone, R. C., W. J. Sibbald, and C. L. Sprung. 1992. The ACCP-SCCM consensus conference on sepsis and organ failure. Chest 101:1481-1483.
8. Chesnutt, M. S., and T. J. Prendergast. 2001. Pulmonary infections, p. 291-300. In L. W. Tierny, S. J. McPhee, and M. A. Papadakis (ed.), Current medical diagnosis and treatment. Lange Medical Publishing/McGraw-Hill Book Co., New York, N.Y.
9. Drusano, G. L. 1988. Role of pharmacokinetics in the outcome of infections. Antimicrob. Agents Chemother. 32:289-297.
10. Food and Drug Administration. 1999. Guidance for industry. Developing antimicrobial drugs - general considerations for clinical trials. [Online.] Food and Drug Administration, U.S. Department of Health and Human Services, Washington, D.C. http://www.fda.gov/cder/guidance/2580dft.pdf.
11. Garau, J., J. Blanquer, L. Cobo, M. Darguerre, de Lattore, F. J., F. C. Leon, del Nogal, A. Net, and J. Rella. 1997. Prospective, randomized multicentre study of meropenem versus imipinem/cilastin as empiric monotherapy in severe nosocomial infections. Eur. J. Clin. Microbiol. Infect. Dis. 16:789-796.
12. Hand, W. L., N. L. King-Thompson, and T. H. Steinberg. 1983. Interactions of antibiotics and phagocytes. J. Antimicrob. Chemother. 12(Suppl. C):1-11.
13. Harf, R., G. Panteix, F. Desnottes, N. Diallo, and M. Leciereq. 1988. Spiramycin uptake by alveolar macrophages. J. Antimicrob. Chemother. 22(Suppl. B):135-140.
14. Herkner, H., M. Müller, R. Kreischitz, N. Mayer, B. Frossard, M. Joukhadar, and C. Klein. 2002. Closed-chest microdialysis to measure antibiotic penetration into human lung. Am. J. Respir. Crit. Care Med. 165:273-276.
15. Honeybourne, D., J. M. Andrews, J. P. Ashby, R. Lodwick, and R. Wise. 1988. Evaluation of the penetration of ciprofloxacin and amoxycillin into the bronchial mucosa. Thorax 43:715-719.
16. Honeybourne, D., and D. R. Baldwin. 1992. The site concentrations of antimicrobial agents in the lung. J. Antimicrob. Chemother. 30:249-260.
17. Hyatt, J. M., P. S. McKinnon, G. S. Zimmer, and J. J. Schentag. 1995. The importance of pharmacokinetic/pharmacodynamic surrogate markers to outcome. Focus on antibacterial agents. Clin. Pharmacokinet. 28:143-160.
18. Jehl, F., P. Birckel, and H. Monteil. 1987. Hospital routine analysis of penicillins, third-generation cephalosporins and aztreonam by conventional and high-speed high-performance liquid chromatography. J. Chromatogr. 413:109-119.
19. Jehl, F., C. Muller-Serieys, V. de Larminat, H. Monteil, and E. Bergogne-Berezin. 1994. Penetration of piperacillin-tazobactam into bronchial secretions after multiple doses to intensive care patients. Antimicrob. Agents Chemother. 38:2780-2784.
20. Joukhadar, C., H. Derendorf, and M. Müller. 2001. Microdialysis, a novel tool for clinical studies of anti-infective agents. Eur. J. Clin. Pharmacol. 57:211-219.
21. Le Conte, P., G. Potel, P. Peltier, D. Horeau, Caillon, M. E. J., Juvin, M. F. Kergueris, D. Bugnon, and D. Baron. 1993. Lung distribution and pharmacokinetics of aerosolized tobramycin. Am. Rev. Respir. Dis. 147:1279-1282.
22. Lönnroth, P., P. A. Jansson, and U. Smith. 1987. A microdialysis method allowing characterization of intercellular water space in humans. Am. J. Physiol. 253:E228-E231.
23. Maier, A., W. Domej, U. Anegg, M. Woltsche, B. Fell, H. Pinter, and F. M. Smolle-Juttner. 2000. CT or ultrasonically guided pigtail catheter drainage in multiloculated pleural empyema: a recommended procedure? Respirology 5:119-124.
24. Miller Reporting Company, Inc. 1989. Guidance documents on developing antimicrobial drugs. Food and Drug Administration, U.S. Department of Health and Human Services, Washington, D.C.
25. Müller, M., R. Schmid, A. Georgopoulos, A. Buxbaum, C. Wasicek, and H. G. Eichler. 1995. Application of microdialysis to clinical pharmacokinetics in humans. Clin. Pharmacol. Ther. 57:371-380.
26. Müller, M., O. Haag, T. Burgdorff, A. Georgopoulos, W. Weninger, B. Jansen, G. Stanek, H. Pehamberger, E. Aeneter, and H. G. Eichler. 1996. Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans. Antimicrob. Agents Chemother. 40:2703-2709.
27. Müller, M. 2000. Microdialysis in clinical drug delivery studies. Adv. Drug Deliv. Rev. 45:255-269.
28. Pennington, J. E. 1981. Penetration of antibiotics into respiratory secretions. Rev. Infect. Dis. 3:67-73.
29. Pfaller, M. A., and R. N. Jones. 1997. A review of the in vitro activity of meropenem and comparative antimicrobial agents tested against 30,254 aerobic and anaerobic pathogens isolated world wide. Diagn. Microbiol. Infect. Dis. 28:157-163.
30. Renner, H., S. Gabor, H. Pinter, A. Maier, G. Friehs, and F. M. Smolle-Jüttner. 1998. Is aggressive surgery in pleural empyema justified? Eur. J. Cardiothorac. Surg. 14:117-122.
31. Ryan, D. M. 1993. Pharmacokinetics of antibiotics in natural and experimental superficial compartments in animals and humans. J. Antimicrob. Chemother. 31(Suppl. D):1-16.
32. Schentag, J. J. 1989. Clinical significance of antibiotic tissue penetration. Clin. Pharmacokinet. 16(Suppl. 1):25-31.
33. Sieger, B., S. J. Berman, R. W. Geckler, S. A. Farkas, et al. 1997. Empiric treatment of hospital-acquired lower respiratory tract infections with meropenem or ceftazidime with tobramycin: a randomized study. Crit. Care Med. 25:1663-1670.
34. Ståhle, L., P. Arner, and U. Ungerstedt. 1991. Drug distribution studies with microdialysis. III. Extracellular concentration of caffeine in adipose tissue in man. Life Sci. 49:1853-1858.
35. The BAL Cooperative Group Steering Committee. 1990. Bronchoalveolar lavage constituents in healthy individuals, idiopathic pulmonary fibrosis, and selected comparison groups. Am. Rev. Respir. Dis. 141:S166-S202.
36. The European Agency for the Evaluation of Medicinal Products. 2000. Evaluation of medicines for human use. Points to consider on pharmacokinetics and pharmacodynamics in the development of antibacterial medicinal products. CPMP/EWP/2655/99. [Online.] The European Agency for the Evaluation of Medicinal Products, London, United Kingdom. http://www.emea.eu .int/pdfs/human/ewp/265599en.pdf.
37. Ungerstedt, U. 1991. Microdialysis-principles and applications for studies in animals and man. J. Intern. Med. 230:365-373.
38. Wang, Y., S. L. Wong, and R. J. Sawchuk. 1993. Microdialysis calibration using retrodialysis zeronet flux: application to a study of the distribution of zidovudine to rabbit cerebrospinal fluid and thalamus. Pharm. Res. 10:1411-1419.
39. Wollmer, P., N. B. Pride, C. G. Rhodes, A. Sanders, V. W. Pike, A. J. Palmer, D. J. Silvester, and R. H. Liss. 1982. Measurement of pulmonary erythromycin concentration in patients with lobar pneumonia by means of positron tomography. Lancet 2:1361-1364.