-
1
-
-
4344660690
-
The mechanisms of the resistance to molecular targeting agents
-
Akiyama S. The mechanisms of the resistance to molecular targeting agents. Nippon Rinsho 2004;62:I297-304.
-
(2004)
Nippon Rinsho
, vol.62
-
-
Akiyama, S.1
-
2
-
-
4344628844
-
Resistance to target-based therapy and its circumvention
-
Nishio K. Resistance to target-based therapy and its circumvention. Nippon Rinsho 2004;62:1343-7.
-
(2004)
Nippon Rinsho
, vol.62
, pp. 1343-1347
-
-
Nishio, K.1
-
3
-
-
2442464889
-
Apoptosis defects and chemotherapy resistance: Molecular interaction maps and networks
-
Pommier Y, Sordet O, Antony S, Hayward RL, Kohn KW. Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene 2004;23:2934-49.
-
(2004)
Oncogene
, vol.23
, pp. 2934-2949
-
-
Pommier, Y.1
Sordet, O.2
Antony, S.3
Hayward, R.L.4
Kohn, K.W.5
-
4
-
-
0032760196
-
Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein
-
Seki N, Hattori A, Hayashi A, et al. Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein, Biochim Biophys Acta 1999;1489:421-7.
-
(1999)
Biochim Biophys Acta
, vol.1489
, pp. 421-427
-
-
Seki, N.1
Hattori, A.2
Hayashi, A.3
-
5
-
-
0242407094
-
The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase
-
Subramaniam V, Li H, Wong M, et al. The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. Br J Cancer 2003;89:1538-44.
-
(2003)
Br J Cancer
, vol.89
, pp. 1538-1544
-
-
Subramaniam, V.1
Li, H.2
Wong, M.3
-
6
-
-
1942469596
-
A central role for the ring finger protein RNF11 in ubiquitin-mediated proteolysis via interactions with E2s and E3s
-
Connor MK, Seth A. A central role for the ring finger protein RNF11 in ubiquitin-mediated proteolysis via interactions with E2s and E3s. Oncogene 2004; 23:2089-95.
-
(2004)
Oncogene
, vol.23
, pp. 2089-2095
-
-
Connor, M.K.1
Seth, A.2
-
7
-
-
0038388266
-
The role of Nedd4/Nedd4-like dependant ubiquitylation in epithelial transport processes
-
Flores SY, Debonneville C, Staub O. The role of Nedd4/Nedd4-like dependant ubiquitylation in epithelial transport processes. Pflugers Arch 2003;446:334-8.
-
(2003)
Pflugers Arch
, vol.446
, pp. 334-338
-
-
Flores, S.Y.1
Debonneville, C.2
Staub, O.3
-
8
-
-
4644312604
-
Negative regulation of transforming growth factor-β (TGF-β) signaling by WW domain-containing protein 1 (WWP1)
-
Komuro A, Imamura T, Saitoh M, et al. Negative regulation of transforming growth factor-β (TGF-β) signaling by WW domain-containing protein 1 (WWP1). Oncogene 2004;23:6914-23.
-
(2004)
Oncogene
, vol.23
, pp. 6914-6923
-
-
Komuro, A.1
Imamura, T.2
Saitoh, M.3
-
9
-
-
1642414402
-
The RINGH2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases
-
Kitching R, Wong MJ, Koehler D, et al. The RINGH2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases. Biochim Biophys Acta 2003;1639:104-12.
-
(2003)
Biochim Biophys Acta
, vol.1639
, pp. 104-112
-
-
Kitching, R.1
Wong, M.J.2
Koehler, D.3
-
10
-
-
1842429946
-
An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein
-
Li H, Seth A. An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. Oncogene 2004;23:1801-8.
-
(2004)
Oncogene
, vol.23
, pp. 1801-1808
-
-
Li, H.1
Seth, A.2
-
11
-
-
0034517389
-
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation
-
Kavsak P, Rasmussen RK, Causing CG, et al. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation. Mol Cell 2000;6:1365-75.
-
(2000)
Mol Cell
, vol.6
, pp. 1365-1375
-
-
Kavsak, P.1
Rasmussen, R.K.2
Causing, C.G.3
-
12
-
-
0036931270
-
Zinc fingers-folds for many occasions
-
Matthews JM, Sunde M. Zinc fingers-folds for many occasions. IUBMB Life 2002;54:351-5.
-
(2002)
IUBMB Life
, vol.54
, pp. 351-355
-
-
Matthews, J.M.1
Sunde, M.2
-
13
-
-
0037470244
-
Protein-protein interactions within an E2-RING finger complex, implications for ubiquitin-dependent DNA damage repair
-
Ulrich HD. Protein-protein interactions within an E2-RING finger complex, implications for ubiquitin-dependent DNA damage repair. J Biol Chem 2003; 278:7051-8.
-
(2003)
J Biol Chem
, vol.278
, pp. 7051-7058
-
-
Ulrich, H.D.1
-
14
-
-
0031913246
-
Mechanism of activation and function of protein kinase B
-
Alessi DR, Cohen P. Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 1998;8:55-62.
-
(1998)
Curr Opin Genet Dev
, vol.8
, pp. 55-62
-
-
Alessi, D.R.1
Cohen, P.2
-
16
-
-
2342565881
-
Advances in protein kinase B signalling: AKTion on multiple fronts
-
Brazil DP, Yang ZZ, Hemmings BA. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 2004;29:233-42.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 233-242
-
-
Brazil, D.P.1
Yang, Z.Z.2
Hemmings, B.A.3
-
17
-
-
18644376449
-
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
-
Liang J, Zubovitz J, Petrocelli T, et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 2002;8:1153-60.
-
(2002)
Nat Med
, vol.8
, pp. 1153-1160
-
-
Liang, J.1
Zubovitz, J.2
Petrocelli, T.3
-
18
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-41.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
-
19
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase akt
-
del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase akt. Science 1997; 278:687-9.
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
Del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
20
-
-
4444358273
-
14-3-3 Proteins - A focus on cancer and human disease
-
Wilker E, Yaffe MB. 14-3-3 Proteins - a focus on cancer and human disease. J Mol Cell Cardiol 2004;37:633-42.
-
(2004)
J Mol Cell Cardiol
, vol.37
, pp. 633-642
-
-
Wilker, E.1
Yaffe, M.B.2
-
21
-
-
12944275670
-
High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer
-
Ferguson AT, Evron E, Umbricht CB, et al. High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. Proc Natl Acad Sci U S A 2000;97:6049-54.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 6049-6054
-
-
Ferguson, A.T.1
Evron, E.2
Umbricht, C.B.3
-
22
-
-
0037138389
-
How do 14-3-3 proteins work? Gatekeeper phosphorylation and the molecular anvil hypothesis
-
Yaffe MB. How do 14-3-3 proteins work? Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Lett 2002;513:53-7.
-
(2002)
FEBS Lett
, vol.513
, pp. 53-57
-
-
Yaffe, M.B.1
-
23
-
-
0345059753
-
The 14-3-3 cancer connection
-
Hermeking H. The 14-3-3 cancer connection. Nat Rev Cancer 2003;3:931-43.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 931-943
-
-
Hermeking, H.1
-
24
-
-
0036672615
-
Specificity of 14-3-3 isoform dimer interactions and phosphorylation
-
Aitken A, Baxter H, Dubois T, et al. Specificity of 14-3-3 isoform dimer interactions and phosphorylation. Biochem Soc Trans 2002;30:351-60.
-
(2002)
Biochem Soc Trans
, vol.30
, pp. 351-360
-
-
Aitken, A.1
Baxter, H.2
Dubois, T.3
-
25
-
-
1642617693
-
PI3K/Akt signalling pathway and cancer
-
Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonzalez-Baron M. PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 2004;30:193-204.
-
(2004)
Cancer Treat Rev
, vol.30
, pp. 193-204
-
-
Fresno Vara, J.A.1
Casado, E.2
De Castro, J.3
Cejas, P.4
Belda-Iniesta, C.5
Gonzalez-Baron, M.6
-
26
-
-
0033628519
-
14-3-3 Proteins and growth control
-
Baldin V. 14-3-3 proteins and growth control. Prog Cell Cycle Res 2000;4:49-60.
-
(2000)
Prog Cell Cycle Res
, vol.4
, pp. 49-60
-
-
Baldin, V.1
-
27
-
-
2142771705
-
Altered bad localization and interaction between bad and bcl-xL in the hippocampus after transient global ischemia
-
Abe T, Takagi N, Nakano M, Furuya M, Takeo S. Altered bad localization and interaction between bad and bcl-xL in the hippocampus after transient global ischemia. Brain Res 2004;1009:159-68.
-
(2004)
Brain Res
, vol.1009
, pp. 159-168
-
-
Abe, T.1
Takagi, N.2
Nakano, M.3
Furuya, M.4
Takeo, S.5
-
28
-
-
0037242575
-
(Kip1) involves a nuclear export signal and links p27 export and proteolysis
-
(Kip1) involves a nuclear export signal and links p27 export and proteolysis. Mol Biol Cell 2003;14:201-13.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 201-213
-
-
Connor, M.K.1
Kotchetkov, R.2
Cariou, S.3
-
29
-
-
0141637441
-
Cbl signaling networks in the regulation of cell function
-
Dikic I, Szymkiewicz I, Soubeyran P. Cbl signaling networks in the regulation of cell function. Cell Mol Life Sci 2003;60:1805-27.
-
(2003)
Cell Mol Life Sci
, vol.60
, pp. 1805-1827
-
-
Dikic, I.1
Szymkiewicz, I.2
Soubeyran, P.3
-
30
-
-
3142726114
-
The cbl family and other ubiquitin ligases: Destructive forces in control of antigen receptor signaling
-
Duan L, Reddi AL, Ghosh A, Dimri M, Band H. The cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity 2004;21:7-17.
-
(2004)
Immunity
, vol.21
, pp. 7-17
-
-
Duan, L.1
Reddi, A.L.2
Ghosh, A.3
Dimri, M.4
Band, H.5
-
31
-
-
0345824732
-
Cell cycle regulatory functions of the human oncoprotein MDM2
-
Deb SP. Cell cycle regulatory functions of the human oncoprotein MDM2. Mol Cancer Res 2003;1:1009-16.
-
(2003)
Mol Cancer Res
, vol.1
, pp. 1009-1016
-
-
Deb, S.P.1
-
33
-
-
0037329056
-
The p53-Mdm2 module and the ubiquitin system
-
Michael D, Oren M. The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 2003;13:49-58.
-
(2003)
Semin Cancer Biol
, vol.13
, pp. 49-58
-
-
Michael, D.1
Oren, M.2
-
34
-
-
0037331103
-
RING finger ubiquitin protein ligases: Implications for tumorigenesis, metastasis and for molecular targets in cancer
-
Fang S, Lorick KL, Jensen JP, Weissman AM. RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer. Semin Cancer Biol 2003;13:5-14.
-
(2003)
Semin Cancer Biol
, vol.13
, pp. 5-14
-
-
Fang, S.1
Lorick, K.L.2
Jensen, J.P.3
Weissman, A.M.4
-
35
-
-
0034092911
-
Regulation of the cdk inhibitor p27 and its deregulation in cancer
-
Slingerland J, Pagano M. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 2000;183:10-7.
-
(2000)
J Cell Physiol
, vol.183
, pp. 10-17
-
-
Slingerland, J.1
Pagano, M.2
-
36
-
-
0036888335
-
Integration of the TGF-β pathway into the cellular signalling network
-
Lutz M, Knaus P. Integration of the TGF-β pathway into the cellular signalling network. Cell Signal 2002;14:977-88.
-
(2002)
Cell Signal
, vol.14
, pp. 977-988
-
-
Lutz, M.1
Knaus, P.2
-
37
-
-
0036965929
-
TGF-β and the smad signal transduction pathway
-
Mehra A, Wrana JL. TGF-β and the smad signal transduction pathway. Biochem Cell Biol 2002;80:605-22.
-
(2002)
Biochem Cell Biol
, vol.80
, pp. 605-622
-
-
Mehra, A.1
Wrana, J.L.2
-
38
-
-
0036910425
-
Two major smad pathways in TGF-β superfamily signalling
-
Miyazawa K, Shinozaki M, Hara T, Furuya T, Miyazono K. Two major smad pathways in TGF-β superfamily signalling. Genes Cells 2002;7:1191-204.
-
(2002)
Genes Cells
, vol.7
, pp. 1191-1204
-
-
Miyazawa, K.1
Shinozaki, M.2
Hara, T.3
Furuya, T.4
Miyazono, K.5
-
39
-
-
0037621860
-
Regulation of TGF-β signaling and its roles in progression of tumors
-
Miyazono K, Suzuki H, Imamura T. Regulation of TGF-β signaling and its roles in progression of tumors. Cancer Sci 2003;94:230-4.
-
(2003)
Cancer Sci
, vol.94
, pp. 230-234
-
-
Miyazono, K.1
Suzuki, H.2
Imamura, T.3
-
40
-
-
0034469509
-
Transforming growth factor-β and breast cancer: Cell cycle arrest by transforming growth factor-β and its disruption in cancer
-
Donovan J, Slingerland J. Transforming growth factor-β and breast cancer: cell cycle arrest by transforming growth factor-β and its disruption in cancer. Breast Cancer Res 2000;2:116-24.
-
(2000)
Breast Cancer Res
, vol.2
, pp. 116-124
-
-
Donovan, J.1
Slingerland, J.2
-
41
-
-
19344374130
-
Smad7 in TGFβ-mediated negative regulation of gut inflammation
-
Mentelone G, Pallone F, MacDonald T. Smad7 in TGFβ-mediated negative regulation of gut inflammation. Trends Immunol 2004;25:513-7.
-
(2004)
Trends Immunol
, vol.25
, pp. 513-517
-
-
Mentelone, G.1
Pallone, F.2
MacDonald, T.3
-
42
-
-
2342618936
-
Multiple roles of the PI3K/PKB (akt) pathway in cell cycle progression
-
Liang J, Slingerland JM. Multiple roles of the PI3K/PKB (akt) pathway in cell cycle progression. Cell Cycle 2003;2:339-45.
-
(2003)
Cell Cycle
, vol.2
, pp. 339-345
-
-
Liang, J.1
Slingerland, J.M.2
|