Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis

Diabetes

Volumn 54, Issue 9, 2005, Pages 2525-2532

  Lee, Chul Ho ^a,b   Reifsnyder, Peter C ^b   Naggert, Jürgen K ^b   Wasserfall, Clive ^c   Atkinson, Mark A ^c   Chen, Jing ^b   Leiter, Edward H ^b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b JACKSON LABORATORY   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; LEPTIN RECEPTOR; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DIABETES MELLITUS; DISEASE COURSE; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; FEMALE; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED NOD; OBESITY; PHENOTYPE; POINT MUTATION; RECEPTORS, CELL SURFACE; TIME FACTORS;

EID: 24144432204     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.9.2525     Document Type: Article

References (26)

1. Serreze DV, Leiter EH: Genes and pathways underlying autoimmune diabetes in NOD mice. In Molecular Pathology of Insulin-Dependent Diabetes Mellitus. von Herrath M, Ed. New York, Karger, 2001, p. 31-67
2. Homo-Delarche F: Neuroendocrine immuno-ontogeny of the pathogenesis of autoimmune disease in the nonobese diabetic (NOD) mouse. ILAR J 45:237-258, 2004
3. Friedman JM: Leptin, leptin receptors and the control of body weight. Nutr Rev 56:S38-S46, 1998
4. Chehab F, Lim M, Lu R: Correction of the sterility defect in homozygous obese females by treatment with the human recombinant leptin. Nat Genet 12:318-320, 1996
5. Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, Ng A, Nicola NA, Alexander WS, Hilton DJ: Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci U S A 93:14564-14568, 1996
6. Bouloumie A, Drexler HC, Lafontan M, Busse R: Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 83:1059-1066, 1998
7. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G: Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100:197-207, 2000
8. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394:897-901, 1998
9. La Cava A, Matarese G: The weight of leptin in immunity. Nat Rev Immunol 4:371-379, 2004
10. Matarese G, Moschos S, Mantzoros CS: Leptin in immunology. J Immunol 173:3137-3142, 2005
11. Lord GM, Matarese G, Howard JK, Bloom SR, Lechler RI: Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T-cells but enhances the production of proinflammatoiy cytokines. J Leukoc Biol 72:330-338, 2002
12. Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A: Leptin accelerates autoimmune diabetes in females NOD mice. Diabetes 51:1356-1361, 2002
13. Nishimura M, Miyamoto H: Immunopathological influence of the Ay, db, ob and nu genes placed on the inbred NOD background as murine models for human type I diabetes J Immunogenet 14:127-130, 1987
14. Serreze DV, Fleming SA, Chapman HD, Richard SD, Leiter EH, Tisch RM: B-lymphocytes are critical antigen presenting cells for the initiation of T-cell mediated autoimmune insulin dependent diabetes in NOD mice. J Immunol 161:3912-3918, 1998
15. Leiter EH, Coleman DL, Eisenstein AB, Strack I: Dietary control of diabetes pathogenesis in C57BL/KsJ db/db diabetes mice. Metabolism 30:554-562, 1981
16. Guberski DL, Butler L, Manzi SM, Stubbs M, Like AA: The BBZ/Wor rat-clinical characteristics of the diabetic syndrome. Diabetologia 36:912-919, 1993
17. Matarese G, Di Giacomo A, Sanna V, Lord GM, Howard JK, Di Tuoro A, Bloom SR, Lechler RI, Zappacosta S, Fontana S: Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol 166:5909-5916, 2001
18. Matarese G, Carrieri PB, La Cava A, Perna F, Sanna V, De Rosa V, Aufiero D, Fontana S, Zappacosta S: Leptin increase in multiple sclerosis associates with reduced number of CD4+CD25+ regulatory T-cells. Proc Natl Acad Sci U S A 102:5150-5155, 2005
19. Hattori M, Yamato E, Matsumoto E, Itoh N, Toyonaga T, Petruzzelli M, Fukuda M, Kobayashi M, Chapman V: Occurrence of pretype I diabetes (pre-IDDM) and type II diabetes (NIDDM) in BC1 [(NOD × Mus spretus)F1 × NOD] mice. In Lessons from Animal Diabetes. Vol. VI. Shafrir E, Ed. Boston, Birkhaüser, 1996, p. 83-95
20. Hao W, Li LS, Mehta V, Lernmark A, Palmer JP: Functional state of the beta cell affects expression of both forms of glutamic acid decarboxylase. Pancreas 9:558-562, 1994
21. Serreze DV, Gaskins HR, Leiter EH: Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice. J Immunol 150:2534-2543, 1993
22. Chen YG, Choisy-Rossi CM, Holl TM, Chapman HD, Besra GS, Porcelli SA, Shaffer DJ, Roopenian D, Wilson SB, Serreze DV: Activated NKT-cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes. J Immunol 174:1196-1204, 2005
23. Ogasawara K, Hamerman JA, Hsin H, Chikuma S, Bour-Jordan H, Chen T, Pertel T, Carnaud C, Bluestone JA, Lanier LL: Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity 18:41-51, 2003
24. Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA: B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T-cells that control autoimmune diabetes. Immunity 12:431-440, 2000
25. Kishimoto H, Sprent J: A defect in central tolerance in NOD mice. Nat Immunol 2:1025-1031, 2001
26. Choisy-Rossi CM, Holl TM, Pierce MA, Chapman HD, Serreze DV: Enhanced pathogenicity of diabetogenic T-cells escaping a non-MHC gene-controlled near death experience. J Immunol 173:3791-3800, 2004