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Volumn 44, Issue 33, 2005, Pages 11148-11159

The transactivation domain of the Ah receptor is a key determinant of cellular localization and ligand-independent nucleocytoplasmic shuttling properties

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; BIODIVERSITY; PROTEINS; SENSITIVITY ANALYSIS;

EID: 23944521767     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050948b     Document Type: Article
Times cited : (51)

References (40)
  • 1
    • 0019225693 scopus 로고
    • Long-term hazards of polychlorinated dibenzodioxins and polychlorinated dibenzofurans
    • Huff, J. E., Moore, J. A., Saracci, R., and Tomatis, L. (1980) Long-term hazards of polychlorinated dibenzodioxins and polychlorinated dibenzofurans, Environ. Health Perspect. 36, 221-240.
    • (1980) Environ. Health Perspect. , vol.36 , pp. 221-240
    • Huff, J.E.1    Moore, J.A.2    Saracci, R.3    Tomatis, L.4
  • 2
    • 0037145025 scopus 로고    scopus 로고
    • The role of chaperone proteins in the aryl hydrocarbon receptor core complex
    • Petrulis, J. R., and Perdew, G. H. (2002) The role of chaperone proteins in the aryl hydrocarbon receptor core complex, Chem. Biol. Interact. 141, 25-40.
    • (2002) Chem. Biol. Interact. , vol.141 , pp. 25-40
    • Petrulis, J.R.1    Perdew, G.H.2
  • 3
    • 0032579265 scopus 로고    scopus 로고
    • Nuclear localization and export signals of the human aryl hydrocarbon receptor
    • Ikuta, T., Eguchi, H., Tachibana, T., Yoneda, Y., and Kawajiri, K. (1998) Nuclear localization and export signals of the human aryl hydrocarbon receptor, J. Biol. Chem. 273, 2895-2904.
    • (1998) J. Biol. Chem. , vol.273 , pp. 2895-2904
    • Ikuta, T.1    Eguchi, H.2    Tachibana, T.3    Yoneda, Y.4    Kawajiri, K.5
  • 5
    • 0034532301 scopus 로고    scopus 로고
    • Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2
    • Petrulis, J. R., Hord, N. G., and Perdew, G. H. (2000) Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2, J. Biol. Chem. 275, 37448-37453.
    • (2000) J. Biol. Chem. , vol.275 , pp. 37448-37453
    • Petrulis, J.R.1    Hord, N.G.2    Perdew, G.H.3
  • 6
    • 0033861976 scopus 로고    scopus 로고
    • Analysis of the complex relationship between nuclear export and aryl hydrocarbon receptor-mediated gene regulation
    • Pollenz, R. S., and Barbour, E. R. (2000) Analysis of the complex relationship between nuclear export and aryl hydrocarbon receptor-mediated gene regulation, Mol. Cell Biol. 20, 6095-6104.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 6095-6104
    • Pollenz, R.S.1    Barbour, E.R.2
  • 7
    • 0037462747 scopus 로고    scopus 로고
    • The hsp90 Co-chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah receptor and represses transcriptional activity
    • Petrulis, J. R., Kusnadi, A., Ramadoss, P., Hollingshead, B., and Perdew, G. H. (2003) The hsp90 Co-chaperone XAP2 Alters Importin beta Recognition of the Bipartite Nuclear Localization Signal of the Ah Receptor and Represses Transcriptional Activity, J. Biol. Chem. 278, 2677-2685.
    • (2003) J. Biol. Chem. , vol.278 , pp. 2677-2685
    • Petrulis, J.R.1    Kusnadi, A.2    Ramadoss, P.3    Hollingshead, B.4    Perdew, G.H.5
  • 8
    • 1642453873 scopus 로고    scopus 로고
    • Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes
    • Ramadoss, P., Petrulis, J. R., Hollingshead, B. D., Kusnadi, A., and Perdew, G. H. (2004) Divergent Roles of Hepatitis B Virus X-Associated Protein 2 (XAP2) in Human versus Mouse Ah Receptor Complexes, Biochemistry 43, 700-709.
    • (2004) Biochemistry , vol.43 , pp. 700-709
    • Ramadoss, P.1    Petrulis, J.R.2    Hollingshead, B.D.3    Kusnadi, A.4    Perdew, G.H.5
  • 9
    • 0026625037 scopus 로고
    • Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor
    • Reyes, H., Reisz-Porszasz, S., and Hankinson, O. (1992) Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor, Science 256, 1193-1195.
    • (1992) Science , vol.256 , pp. 1193-1195
    • Reyes, H.1    Reisz-Porszasz, S.2    Hankinson, O.3
  • 10
    • 0037450429 scopus 로고    scopus 로고
    • Functional role of AhR in the expression of toxic effects by TCDD
    • Mimura, J., and Fujii-Kuriyama, Y. (2003) Functional role of AhR in the expression of toxic effects by TCDD, Biochim. Biophys. Acta 1619, 263-268.
    • (2003) Biochim. Biophys. Acta , vol.1619 , pp. 263-268
    • Mimura, J.1    Fujii-Kuriyama, Y.2
  • 11
    • 0033166447 scopus 로고    scopus 로고
    • p27-(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells
    • Kolluri, S. K., Weiss, C., Koff, A., and Gottlicher, M. (1999) p27-(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells, Genes Dev. 13, 1742-1753.
    • (1999) Genes Dev. , vol.13 , pp. 1742-1753
    • Kolluri, S.K.1    Weiss, C.2    Koff, A.3    Gottlicher, M.4
  • 12
    • 0035576809 scopus 로고    scopus 로고
    • Novel target genes of the Ah (dioxin) receptor: Transcriptional induction of N-myristoyltransferase 2
    • Kolluri, S. K., Balduf, C., Hofmann, M., and Gottlicher, M. (2001) Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2, Cancer Res. 61, 8534-8539.
    • (2001) Cancer Res. , vol.61 , pp. 8534-8539
    • Kolluri, S.K.1    Balduf, C.2    Hofmann, M.3    Gottlicher, M.4
  • 14
    • 0026725943 scopus 로고
    • Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor
    • Burbach, K. M., Poland, A., and Bradfield, C. A. (1992) Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor, Proc. Natl. Acad. Sci. U.S.A. 89, 8185-8189.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 8185-8189
    • Burbach, K.M.1    Poland, A.2    Bradfield, C.A.3
  • 15
    • 0028858097 scopus 로고
    • Identification of functional domains of the aryl hydrocarbon receptor
    • Fukunaga, B. N., Probst, M. R., Reisz-Porszasz, S., and Hankinson, O. (1995) Identification of functional domains of the aryl hydrocarbon receptor, J. Biol. Chem. 270, 29270-29278.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29270-29278
    • Fukunaga, B.N.1    Probst, M.R.2    Reisz-Porszasz, S.3    Hankinson, O.4
  • 16
    • 0035900692 scopus 로고    scopus 로고
    • Differential usage of nuclear export sequences regulates intracellular localization of the dioxin (aryl hydrocarbon) receptor
    • Berg, P., and Pongratz, I. (2001) Differential usage of nuclear export sequences regulates intracellular localization of the dioxin (aryl hydrocarbon) receptor, J. Biol. Chem. 276, 43231-43238.
    • (2001) J. Biol. Chem. , vol.276 , pp. 43231-43238
    • Berg, P.1    Pongratz, I.2
  • 17
    • 0029019489 scopus 로고
    • Transcriptional activation by the mouse Ah receptor. Interplay between multiple stimulatory and inhibitory functions
    • Ma, Q., Dong, L., and Whitlock, J. P., Jr. (1995) Transcriptional activation by the mouse Ah receptor. Interplay between multiple stimulatory and inhibitory functions, J. Biol. Chem. 270, 12697-12703.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12697-12703
    • Ma, Q.1    Dong, L.2    Whitlock Jr., J.P.3
  • 18
    • 0023653349 scopus 로고
    • Variation in the molecular mass of the Ah receptor among vertebrate species and strains of rats
    • Poland, A., and Glover, E. (1987) Variation in the molecular mass of the Ah receptor among vertebrate species and strains of rats, Biochem. Biophys. Res. Commun. 146, 1439-1449.
    • (1987) Biochem. Biophys. Res. Commun. , vol.146 , pp. 1439-1449
    • Poland, A.1    Glover, E.2
  • 21
    • 0034807691 scopus 로고    scopus 로고
    • The AH receptor of the most dioxin-sensitive species, guinea pig, is highly homologous to the human AH receptor
    • Korkalainen, M., Tuomisto, J., and Pohjanvirta, R. (2001) The AH receptor of the most dioxin-sensitive species, guinea pig, is highly homologous to the human AH receptor, Biochem. Biophys. Res. Commun. 285, 1121-1129.
    • (2001) Biochem. Biophys. Res. Commun. , vol.285 , pp. 1121-1129
    • Korkalainen, M.1    Tuomisto, J.2    Pohjanvirta, R.3
  • 23
    • 0018148562 scopus 로고
    • The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs
    • McConnell, E. E., Moore, J. A., Haseman, J. K., and Harris, M. W. (1978) The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs, Toxicol. Appl. Pharmacol. 44, 335-356.
    • (1978) Toxicol. Appl. Pharmacol. , vol.44 , pp. 335-356
    • McConnell, E.E.1    Moore, J.A.2    Haseman, J.K.3    Harris, M.W.4
  • 24
    • 0019493439 scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Acute oral toxicity in hamsters
    • Henck, J. M., New, M. A., Kociba, R. J., and Rao, K. S. (1981) 2,3,7,8-tetrachlorodibenzo-p-dioxin: acute oral toxicity in hamsters, Toxicol. Appl. Pharmacol. 59, 405-407.
    • (1981) Toxicol. Appl. Pharmacol. , vol.59 , pp. 405-407
    • Henck, J.M.1    New, M.A.2    Kociba, R.J.3    Rao, K.S.4
  • 25
    • 0028170453 scopus 로고
    • Effect of 2,3,7,8-tetrachlorodibenzoy-p-dioxin on the hepatic 7-ethoxyresorufin O-deethylase activity in four rodent species
    • Hakansson, H., Johansson, L., Manzoor, E., and Ahlborg, U. G. (1994) Effect of 2,3,7,8-tetrachlorodibenzoy-p-dioxin on the hepatic 7-ethoxyresorufin O-deethylase activity in four rodent species, Eur. J. Pharmacol. 270, 279-284.
    • (1994) Eur. J. Pharmacol. , vol.270 , pp. 279-284
    • Hakansson, H.1    Johansson, L.2    Manzoor, E.3    Ahlborg, U.G.4
  • 26
    • 0021940487 scopus 로고
    • Dose-related effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J and DBA/2J mice
    • Chapman, D. E., and Schiller, C. M. (1985) Dose-related effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J and DBA/2J mice, Toxicol. Appl. Pharmacol. 78, 147-157.
    • (1985) Toxicol. Appl. Pharmacol. , vol.78 , pp. 147-157
    • Chapman, D.E.1    Schiller, C.M.2
  • 28
    • 0027944549 scopus 로고
    • Analysis of the four alleles of the murine aryl hydrocarbon receptor
    • Poland, A., Palen, D., and Glover, E. (1994) Analysis of the four alleles of the murine aryl hydrocarbon receptor, Mol Pharmacol 46, 915-921.
    • (1994) Mol Pharmacol , vol.46 , pp. 915-921
    • Poland, A.1    Palen, D.2    Glover, E.3
  • 29
    • 0027484423 scopus 로고
    • Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on plasma and tissue beta-endorphin-like immunoreactivity in the most TCDD-susceptible and the most TCDD-resistant rat strain
    • Pohjanvirta, R., Unkila, M., Tuomisto, J. T., Vuolteenaho, O., Leppaluoto, J., and Tuomisto, J. (1993) Effect of 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) on plasma and tissue beta-endorphin-like immunoreactivity in the most TCDD-susceptible and the most TCDD-resistant rat strain, Life Sci. 53, 1479-1487.
    • (1993) Life Sci. , vol.53 , pp. 1479-1487
    • Pohjanvirta, R.1    Unkila, M.2    Tuomisto, J.T.3    Vuolteenaho, O.4    Leppaluoto, J.5    Tuomisto, J.6
  • 30
    • 0035834750 scopus 로고    scopus 로고
    • The Q-rich subdomain of the human Ah receptor transactivation domain is required for dioxin-mediated transcriptional activity
    • Kumar, M. B., Ramadoss, P., Reen, R. K., Vanden Heuvel, J. P., and Perdew, G. H. (2001) The Q-rich subdomain of the human Ah receptor transactivation domain is required for dioxin-mediated transcriptional activity, J. Biol. Chem. 276, 42302-42310.
    • (2001) J. Biol. Chem. , vol.276 , pp. 42302-42310
    • Kumar, M.B.1    Ramadoss, P.2    Reen, R.K.3    Vanden Heuvel, J.P.4    Perdew, G.H.5
  • 31
    • 0031845222 scopus 로고    scopus 로고
    • Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8- tetrachlorodibenzo-p-dioxin-resistant rat strain
    • Pohjanvirta, R., Wong, J. M., Li, W., Harper, P. A., Tuomisto, J., and Okey, A. B. (1998) Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain, Mol. Pharmacol. 54, 86-93.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 86-93
    • Pohjanvirta, R.1    Wong, J.M.2    Li, W.3    Harper, P.A.4    Tuomisto, J.5    Okey, A.B.6
  • 32
    • 0023885681 scopus 로고
    • Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz[a]-anthracene in the human A431 squamous cell carcinoma line
    • Harper, P. A., Golas, C. L., and Okey, A. B. (1988) Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz[a]-anthracene in the human A431 squamous cell carcinoma line. Cancer Res. 48, 2388-2395.
    • (1988) Cancer Res. , vol.48 , pp. 2388-2395
    • Harper, P.A.1    Golas, C.L.2    Okey, A.B.3
  • 33
    • 0028034621 scopus 로고
    • Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors
    • Ema, M., Ohe, N., Suzuki, M., Mimura, J., Sogawa, K., Ikawa, S., and Fujii-Kuriyama, Y. (1994) Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors, J. Biol. Chem. 269, 27337-27343.
    • (1994) J. Biol. Chem. , vol.269 , pp. 27337-27343
    • Ema, M.1    Ohe, N.2    Suzuki, M.3    Mimura, J.4    Sogawa, K.5    Ikawa, S.6    Fujii-Kuriyama, Y.7
  • 34
    • 3042677511 scopus 로고    scopus 로고
    • Use of 2-azido-3-[125I]-iodo-7,8-dibromodibenzo-p-dioxin as a probe to determine the relative ligand affinity of human versus mouse aryl hydrocarbon receptor in cultured cells
    • Ramadoss, P., and Perdew, G. H. (2004) Use of 2-azido-3-[125I]-iodo-7,8- dibromodibenzo-p-dioxin as a probe to determine the relative ligand affinity of human versus mouse aryl hydrocarbon receptor in cultured cells, Mol. Pharmacol. 66, 129-136.
    • (2004) Mol. Pharmacol. , vol.66 , pp. 129-136
    • Ramadoss, P.1    Perdew, G.H.2
  • 35
    • 0031882767 scopus 로고    scopus 로고
    • Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity
    • Meyer, B. K., Pray-Grant, M. G., Vanden Heuvel, J. P., and Perdew, G. H. (1998) Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity, Mol. Cell Biol. 18, 978-988.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 978-988
    • Meyer, B.K.1    Pray-Grant, M.G.2    Vanden Heuvel, J.P.3    Perdew, G.H.4
  • 36
    • 0033729426 scopus 로고    scopus 로고
    • Generation of deletion and point mutations with one primer in a single cloning step
    • Makarova, O., Kamberov, E., and Margolis, B. (2000) Generation of deletion and point mutations with one primer in a single cloning step, Biotechniques 29, 970-972.
    • (2000) Biotechniques , vol.29 , pp. 970-972
    • Makarova, O.1    Kamberov, E.2    Margolis, B.3
  • 37
    • 0029003424 scopus 로고
    • Production and characterization of monoclonal antibodies directed against the Ah receptor
    • Perdew, G. H., Abbott, B., and Stanker, L. H. (1995) Production and characterization of monoclonal antibodies directed against the Ah receptor, Hybridoma 14, 279-283.
    • (1995) Hybridoma , vol.14 , pp. 279-283
    • Perdew, G.H.1    Abbott, B.2    Stanker, L.H.3
  • 39
    • 0029803550 scopus 로고    scopus 로고
    • XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation
    • Kuzhandaivelu, N., Cong, Y. S., Inouye, C., Yang, W. M., and Seto, E. (1996) XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation, Nucleic Acids Res. 24, 4741-4750.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4741-4750
    • Kuzhandaivelu, N.1    Cong, Y.S.2    Inouye, C.3    Yang, W.M.4    Seto, E.5


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