Investigating the neuroprotective mechanism of action of a CDK5 inhibitor by phosphoproteome analysis

Journal of Cellular Biochemistry

Volumn 95, Issue 4, 2005, Pages 817-826

  Gillardon, Frank ^a   Schrattenholz, André ^b   Sommer, Bernd ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b PROTEOSYS AG   (Germany)

Author keywords

Cyclin dependent kinase; Neuroprotection; Phosphorylation; Stress response; Two dimensional gel electrophoresis

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE INHIBITOR; INDOLINONE A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROPROTECTIVE AGENT; NEUROTRANSMITTER; PHOSPHOPROTEIN; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; CDK5 PROTEIN, RAT; CYCLIN DEPENDENT KINASE; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEOME;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CEREBELLUM; CONTROLLED STUDY; DRUG MECHANISM; ENERGY METABOLISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GRANULE CELL; IMMUNOCYTOCHEMISTRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FOLDING; RAT; TWO DIMENSIONAL GEL ELECTROPHORESIS; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; NERVE CELL; PHOSPHORYLATION; PROTEOMICS; SIGNAL TRANSDUCTION; WISTAR RAT;

MAMMALIA;

ANIMALS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME ACTIVATION; INDOLES; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEOME; PROTEOMICS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 23944464794     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20463     Document Type: Article

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