Zinc and infection: A review

Annals of Tropical Paediatrics

Volumn 25, Issue 3, 2005, Pages 149-160

  Cuevas, Luis E ^a   Koyanagi, Ai ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMONY; GAMMA INTERFERON; INTERLEUKIN 2; ORAL REHYDRATION SOLUTION; PLACEBO; RECOMBINANT INTERLEUKIN 12; RECOMBINANT INTERLEUKIN 2; RECOMBINANT INTERLEUKIN 9; RETINOL; TUBERCULOSTATIC AGENT; TUMOR NECROSIS FACTOR ALPHA; ZINC;

DISEASE INCIDENCE; FOOD SUPPLEMENTATION; RISK FACTOR; ZINC;

ACRODERMATITIS ENTEROPATHICA; ANOREXIA; BACTERIAL INFECTION; BEHAVIOR DISORDER; CELLULAR IMMUNITY; CHILD; CHILD NUTRITION; CHILDHOOD MORTALITY; CLINICAL TRIAL; CONVALESCENCE; CYTOKINE PRODUCTION; DERMATITIS; DEVELOPING COUNTRY; DIARRHEA; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; GROWTH RETARDATION; HUMAN; INFECTION; INFECTION SENSITIVITY; LEISHMANIA; LEISHMANIASIS; LEPROMATOUS LEPROSY; LUNG TUBERCULOSIS; MALARIA FALCIPARUM; MEDICAL RESEARCH; META ANALYSIS; MOOD DISORDER; MORBIDITY; MOUSE; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; MYCOSIS; NAUSEA AND VOMITING; NONHUMAN; NUTRITIONAL DEFICIENCY; PLASMODIUM FALCIPARUM; PNEUMONIA; PROSTATE CANCER; RESPIRATORY TRACT INFECTION; REVIEW; SYMPTOM; SYSTEMATIC REVIEW; TASTE DISORDER; TH1 CELL; TH2 CELL; ZINC DEFICIENCY;

ACUTE DISEASE; ADULT; CHILD; COMMUNICABLE DISEASES; DEVELOPING COUNTRIES; DIARRHEA; DIETARY SUPPLEMENTS; HUMANS; IMMUNITY, CELLULAR; LEISHMANIASIS; LEPROSY, LEPROMATOUS; MALARIA; RESPIRATORY TRACT INFECTIONS; TUBERCULOSIS; ZINC;

EID: 23944454567     PISSN: 02724936     EISSN: None     Source Type: Journal    
DOI: 10.1179/146532805X58076     Document Type: Review

References (105)

1. Chakravarty I, Sinha RK. Prevalence of micronutrient deficiency based on results obtained from the national pilot program on control of micronutrient malnutrition. Nutr Rev 2002; 60 (5 Pt 2):S53-8.
2. Koyanagi A, Kuffo D, Gresely L, Shenkin A, Cuevas LE. Relationships between serum concentrations of C-reactive protein and micronutrients, in patients with tuberculosis. Ann Trop Med Parasitol 2004; 98:391-9.
3. Bhutta Z, Black R, Brown K, et al. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. J Pediatr 1999; 135:689-97.
4. Baqui A, Black R, El Arifeen S, et al. Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. Br Med J 2002; 325:1059.
5. Shankar A, Prasad A. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998; 68:447S-63.
6. Pekarek R, Sandstead H, Jacob R, Barcome D. Abnormal cellular immune responses during acquired zinc deficiency. Am J Clin Nutr 1979; 32:1466-71.
7. Chandra RK, Au B. Single nutrient deficiency and cell-mediated immune responses. I. Zinc. Am J Clin Nutr 1980; 334:736-8.
8. Arsenault JE, Brown KH. Zinc intake of preschool children exceeds new dietary reference intakes. Am J Clin Nutr 2003; 78:1011-17.
9. Chandra R. Acrodermatitis enteropathica: zinc levels and cell-mediated immunity. Pediatrics 1980; 66:789-91.
10. Sehgal VN, Jain S. Acrodermatitis enteropathica. Clin Dermatol 2000; 18:745-8.
11. Ghishan F. Transport of electrolytes, water, and glucose in zinc deficiency. J Pediatr Gastroenterol Nutr 1984; 3:608-12.
12. Patrick J, Golden BE, Golden MH. Leucocyte sodium transport and dietary zinc in protein energy malnutrition. Am J Clin Nutr 1980; 33:617-20.
13. Roy S, Behrens R, Haider R, et al. Impact of zinc supplementation on intestinal permeability in Bangladeshi children with acute diarrhoea and persistent diarrhoea syndrome. J Pediatr Gastroenterol Nutr 1992; 15:289-96.
14. Blanchard R, Cousins R. Upregulation of rat intestinal uroguanylin mRNA by dietary zinc restriction. Am J Physiol 1997; 272 (5 Pt 1):G972-8.
15. Gebhard RL, Karouani R, Prigge WF, McClain CJ. The effect of severe zinc deficiency on activity of intestinal disaccharidases and 3-hydroxy-3-methylglutaryl coenzyme A reductase in the rat. J Nutr 1983; 113:855-9.
16. Bettger W, O'Dell B. A critical physiological role of zinc in the structure and function of biomembranes. Life Sci 1981; 28:1425-38.
17. Arcasoy A, Akar N, Ors U, Delilbasi L, Karayalcin S. Ultrastructural changes in the mucosa of the small intestine in patients with geophagia (Prasad's syndrome). J Pediatr Gastroenterol Nutr 1990; 11:279-82.
18. Bitarakwate E, Mworozi E, Kekitiinwa A. Serum zinc status of children with persistent diarrhoea admitted to the diarrhoea management unit of Mulago Hospital, Uganda. Afr Health Sci 2003; 3:54-60.
19. Chaudhary S, Verma M, Dhawan V, et al. Plasma vitamin A, zinc and selenium concentrations in children with acute and persistent diarrhoea. J Diarrhoeal Dis Res 1996; 14:190-3.
20. Rodriguez A, Soto G, Torres S, Venegas G, Castillo-Duran C. Zinc and copper in hair and plasma of children with chronic diarrhea. Acta Paediatr Scand 1985; 74:770-4.
21. Sachdev HP, Mittal NK, Yadav HS. Serum and rectal mucosal zinc levels in acute and chronic diarrhea. Indian Pediatr 1990; 27:125-33.
22. Bahl R, Bhandari N, Hambidge KM, Bhan MK. Plasma zinc as a predictor of diarrheal and respiratory morbidity in children in an urban slum setting. Am J Clin Nutr 1998; 68 (2 Suppl):414S-17S.
23. Umeta M, West CE, Haidar J, Deurenberg P, Hautvast J. Zinc supplementation and stunted infants in Ethiopia: a randomized controlled trial. Lancet 2000; 355:2021-6.
24. Muller O, Becher H, Van Zweeden A, et al. Effect of zinc supplementation on malaria and other causes of morbidity in west African children: randomized double blind placebo controlled trial. Br Med J 2001; 322:1-6.
25. Bhandari N, Bahl R, Taneja S, et al. Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young north Indian children. Pediatrics 2002; 109:e86.
26. Osendarp SJ, Santosham M, Black RE, Wahed MA, van Raaij JM, Fuchs GJ. Effect of zinc supplementation between 1 and 6 mo of life on growth and morbidity of Bangladeshi infants in urban slums. Am J Clin Nutr 2002; 76:1401-8.
27. Dutta P, Mitra U, Datta A, et al. Impact of zinc supplementation in malnourished children with acute watery diarrhoea. J Trop Pediatr 2000; 46:259-63.
28. Strand T, Chandyo R, Bahl R, et al. Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children. Pediatrics 2002; 109:898-903.
29. Al-Sonboli N, Gurgel RQ, Shenkin A, Hart CA, Cuevas LE. Zinc supplementation in Brazilian children with acute diarrhoea. Ann Trop Paediatr 2003; 23:3-8.
30. Raqib R, Roy SK, Rahman MJ, et al. Effect of zinc supplementation on immune and inflammatory responses in pediatric patients with shigellosis. Am J Clin Nutr 2004; 79:444-50.
31. Bahl R, Bhandari N, Saksena M, et al. Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea. J Pediatr 2002; 141:677-82.
32. Fontaine O. Effect of zinc supplementation on clinical course of acute diarrhoea. J Health Popul Nutr 2001; 19:339-46.
33. Penny M, Peerson J, Marin R, et al. Randomized, community-based trial of the effect of zinc supplementation, with and without other micronutrients, on the duration of persistent childhood diarrhea in Lima, Peru. J Pediatr 1999; 135 (2 Pt 1):208-17.
34. Roy SK, Tomkins AM, Mahalanabis D, et al. Impact of zinc supplementation on persistent diarrhoea in malnourished Bangladeshi children. Acta Paediatr 1998; 87:1235-9.
35. Ruel M, Rivera J, Santizo M, Lonnerdal B, Brown K. Impact of zinc supplementation on morbidity from diarrhea and respiratory infections among rural Guatemalan children. Pediatrics 1997; 99:808-13.
36. Bhutta ZA, Bird SM, Black RE, et al. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. Am J Clin Nutr 2000; 72:1516-22.
37. Black R, Therapeutic and preventive effects of zinc on serious childhood infectious diseases in developing countries. Am J Clin Nutr 1998; 68:476S-9S.
38. Roy SK, Tomkins AM, Haider R, et al. Impact of zinc supplementation on subsequent growth and morbidity in Bangladeshi children with acute diarrhoea. Eur J Clin Nutr 1999; 53:529-34.
39. Sempertegui F, Estrella B, Correa E, et al. Effects of short-term zinc supplementation on cellular immunity, respiratory symptoms, and growth of malnourished Equadorian children. Eur J Clin Nutr 1996; 50:42-6.
40. Baqui AH, Zaman K, Persson LA, et al. Simultaneous weekly supplementation of iron and zinc is associated with lower morbidity due to diarrhea and acute lower respiratory infection in Bangladeshi infants. J Nutr 2003; 133:4150-7.
41. Bhandari N, Bahl R, Taneja S, et al. Effect of routine zinc supplementation on pneumonia in children aged 6 months to 3 years: randomized controlled trial in an urban slum. Br Med J 2002; 324:1358-62.
42. Sazawal S, Black RE, Jalla S, Mazumdar S, Sinha A, Bhan MK. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial. Pediatrics 1998; 102 (1 Pt 1):1-5.
43. Mahalanabis D, Lahiri M, Paul D, et al. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection. Am J Clin Nutr 2004; 79:430-6.
44. Mahalanabis D, Chowdhury A, Jana S, Bhattacharya M, Wahed M, Khaled M. Zinc supplementation as adjunct therapy in children with measles accompanied by pneumonia: a double-blind, randomized controlled trial. Am J Clin Nutr 2002; 76:604-7.
45. Zinc Against Plasmodium Study Group. Effect of zinc on the treatment of Plasmodium falciparum malaria in children: a randomized controlled trial. Am J Clin Nutr 2002; 76:805-12.
46. Shankar A, Genton B, Baisor M, et al. Zinc supplementation can reduce malaria related morbidity in preschool children. Am J Trop Med Hyg 1997; 57:249.
47. Bates C, Evans P, Dardenne M, et al. A trial of zinc supplementation in young rural Gambian children. Br J Nutr 1993; 69:243-55.
48. Oppenheim J, Neta R. Pathophysiological roles of cytokines in development, immunity, and inflammation. FASEB J 1994; 8:158-62.
49. Ismail N, Olano J, Feng H, Walker D. Current status of immune mechanisms of killing intracellular microorganisms. FEMS Microbiol Lett 2002; 207:111-20.
50. Saha K, Rao KN. Undernutrition in lepromatous leprosy. V. Severe nutritional deficit in lepromatous patients co-infected with pulmonary tuberculosis. Eur J Clin Nutr 1989; 43:117-28.
51. Delobel P, Launois P, Djossou F, Sainte-Marie D, Pradinaud R. American cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis coinfection with downregulation of the T-helper 1 cell response. Clin Infect Dis 2003; 37:628-33.
52. Sprietsma J. Zinc-controlled Th1/Th2 switch significantly determines development of diseases. Med Hypotheses 1997; 49:1-14.
53. Prasad AS. Effects of zinc deficiency on Th1 and Th2 cytokine shifts. J Infect Dis 2000; 182 (Suppl 1):S62-8.
54. Beck FW, Prasad AS, Kaplan J, Fitzgerald JT, Brewer GJ. Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Am J Physiol 1997; 272:E1002-7.
55. Botha T, Ryffel B. Reactivation of latent tuberculosis infection in TNF-deficient mice. J Immunol 2003; 171:3110-18.
56. Kawakami K, Teruya K, Tohyama M, Kudeken N, Saito A. A therapeutic trial of experimental tuberculosis with gamma-interferon in an immunocompromised mouse model. Kekkaku 1994; 69:607-13 [in Japanese].
57. Keane J, Gershon S, Wise RP, et al. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 2001; 345:1098-104.
58. Martinez ON, Noiseux CR, Martin JAC, Lara VG. Reactivation tuberculosis in a patient with anti-TNF-alpha treatment. Am J Gastroenterol 2001; 96:1665-6.
59. Mayordomo L, Marenco J, Gomez-Mateos J, Rejon E. Pulmonary miliary tuberculosis in a patient with anti-TNF-alpha treatment. Scand J Rheumatol 2002; 31:44-5.
60. Newport MJ, Huxley CM, Huston S, et al. A mutation in the interferon-gamma -receptor gene and susceptibility to mycobacterial infection. N Engl J Med 1996; 335:1941-9.
61. Guerin PJ, Olliaro P, Sundar S, et al. Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infect Dis 2002; 2:494-501.
62. Corbett EL, Steketee RW, ter Kuile FO, Latif AS, Kamali A, Hayes RJ. HIV-1/AIDS and the control of other infectious diseases in Africa. Lancet 2002; 359:2177-87.
63. Sharda B, Bhandari B. Serum zinc in childhood pulmonary tuberculosis. Indian Pediatr 1977; 14:987-8.
64. Ahmad P, Garg R, Salahuddin A. Serum zinc and copper in tuberculosis. Indian Pediatr 1985; 22:786-8.
65. Bogden J, Lintz D, Joselow M, Charles J, Salaki J. Effect of pulmonary tuberculosis on blood concentrations of copper and zinc. Am J Clin Pathol 1977; 67:251-6.
66. Sinha R, Khan A, Singh B. Importance of serum zinc and copper in pulmonary tuberculosis of childhood. J Indian Med Assoc 1985; 83:342-4.
67. Pant K, Biswas S, Chawla R, Shah A, Singh M. Zinc in active tuberculosis. Indian J Chest Dis Allied Sci 1987; 29:144-9.
68. Taneja D. Observations on serum zinc in patients of pulmonary tuberculosis. J Indian Med Assoc 1990; 88:280-1.
69. Ray M, Kumar L, Prasad R. Plasma zinc status in Indian childhood tuberculosis; impact of antituberculosis therapy. Int J Tuberc Lung Dis 1998; 2:719-25.
70. Niculescu T, Dumitru R, Burnea D. Changes of copper, iron, and zinc in the serum of patients with silicosis, silicotuberculosis, and active lung tuberculosis. Environ Res 1981; 25:260-8.
71. Karyadi E, Schultink W, Nelwan RHH, et al. Poor micronutrient status of active pulmonary tuberculosis patients in Indonesia. J Nutr 2000; 130:2953-8.
72. Cuevas L, Almeida L, Mazunder P, et al. Effect of zinc on the tuberculin response of children exposed to adults with smear-positive tuberculosis. Ann Trop Paediatr 2002; 22:313-19.
73. Karyadi E, West CE, Schultink W, et al. A double-blind, placebo-controlled study of vitamin A and zinc supplementation in persons with tuberculosis in Indonesia: effects on clinical response and nutritional status. Am J Clin Nutr 2002; 75: 720-7.
74. Prasad AS, Beck FW, Kaplan J, et al. Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD). Am J Hematol 1999; 61:194-202.
75. Johnson B, Ress S, Willcox P, et al. Clinical and immune responses of tuberculosis patients treated with low-dose IL-2 and multidrug therapy. Cytokines Mol Ther 1995; 1:185-96.
76. Johnson BJ, Bekker LG, Rickman R, et al. rhuIL-2 adjunctive therapy in multidrug resistant tuberculosis: a comparison of two treatment regimens and placebo. Tuber Lung Dis 1997; 78:195-203.
77. Johnson JL, Ssekasanvu E, Okwera A, et al. Randomized trial of adjunctive interleukin-2 in adults with pulmonary tuberculosis. Am J Respir Crit Care Med 2003; 168:185-91.
78. Lienhardt C, Azzurri A, Amedei A, et al. Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo. Eur J Immunol 2002; 32:1605-13.
79. Saxena N, Sharma RP, Singh VS. Study of serum zinc level in leprosy. Indian J Lepr 1988; 60: 556-61.
80. Mathur N, Bumb R, Mangal H, Sharma M. Oral zinc as an adjunct to dapsone in lepromatous leprosy. Int J Lepr Other Mycobact Dis 1984; 52:331-8.
81. George J, Bhatia VN, Balakrishnan S, Ramu G. Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states. Int J Lepr Other Mycobact Dis 1991; 59:20-4.
82. Mennen U, Howells C, Wiese AJ. Serum zinc, sodium, calcium, magnesium and potassium levels and standard diet in leprosy patients. Indian J Lepr 1993; 65:415-21.
83. Sethi NC, Madadi AJ, Bhandari S. Serum zinc, copper, magnesium, proteins and superoxide dismutase in leprosy patients on multidrug therapy - a follow-up study. Indian J Lepr 1996; 68:325-33.
84. Sher R, Shulman G, Baily P, Politzer WM. Serum trace elements and vitamin A in leprosy subtypes. Am J Clin Nutr 1981; 34:1918-24.
85. Mathur NK, Sharma M, Mangal HN, Rai SM. Serum zinc levels in subtypes of leprosy. Int J Lepr Other Mycobact Dis 1984; 52:327-30.
86. Plagnol H, Languillon J. C-reactive protein and leprosy. Supplementary note. Med Trop 1967; 27:49-52 [in French].
87. Mahajan P, Jadhav V, Patki A, Jogaikar D, Mehta J. Oral zinc therapy in recurrent erythema nodosum leprosum: a clinical study. Indian J Lepr 1994; 66:51-7.
88. Strickland T. Hunter's Tropical Medicine and Emerging Infectious Diseases, 8th edn. Philadelphia, PA: WB Saunders, 2000.
89. Kaplan G, Britton WJ, Hancock GE, et al. The systemic influence of recombinant interleukin 2 on the manifestations of lepromatous leprosy. J Exp Med 1991; 173:993-1006.
90. Kaplan G, Kiessling R, Teklemariam S, et al. The reconstitution of cell-mediated immunity in the cutaneous lesions of lepromatous leprosy by recombinant interleukin 2. J Exp Med 1989; 169:893-907.
91. Anstead GM, Chandrasekar B, Zhao W, Yang J, Perez LE, Melby PC. Malnutrition alters the innate immune response and increases early visceralization following Leishmania donovani infection. Infect Immun 2001; 69:4709-18.
92. Kocyigit A, Erel O, Seyrek A, et al. Effects of antimonial therapy on serum zinc, copper and iron concentrations in patients with cutaneous Leishmaniasis in Turkey. J Egypt Soc Parasitol 1998; 28:133-42.
93. Singh U, Patwari A, Sinha R, Kumar R. Prognostic value of serum C-reactive protein in kala-azar. J Trop Pediatr 1999; 45:226-8.
94. Wasunna K, Raynes J, Were J, et al. Acute phase protein concentrations predict parasite clearance rate during therapy for visceral leishmaniasis. Trans R Soc Trop Med Hyg 1995; 89:678-81.
95. Akuffo H, Kaplan G, Kiessling R, et al. Administration of recombinant interleukin-2 reduces the local parasite load of patients with disseminated cutaneous leishmaniasis. J Infect Dis 1990; 161:775-80.
96. Squires K, Rosenkaimer F, Sherwood J, Forni A, Were J, Murray H. Immunochemotherapy for visceral leishmaniasis: a controlled pilot trial of antimony versus antimony plus interferon-gamma. Am J Trop Med Hyg 1993; 48:666-9.
97. Badaro R, Falcoff E, Badaro F, et al. Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. N Engl J Med 1990; 322:16-21.
98. Lewis MR, Kokan L. Zinc gluconate: acute ingestion. J Toxicol Clin Toxicol 1999; 36:99-101.
99. Festa MD, Anderson HL, Dowdy RP, Ellersick MR. Effect of zinc intake on copper excretion and retention in men. Am J Clin Nutr 1985; 41:285-92.
100. Chardra RK. Excessive intake of zinc impairs immune responses. JAMA 1984; 252:1443-6.
101. Doherty CP, Sarkar MAK, Shakur MS, Ling SC, Elton RA, Cutting WA. Zinc and rehabilitation from severe protein-energy malnutrition: higher dose regimens are associated with increased mortality. Am J Clin Nutr 1998; 68:742-8.
102. Zalewski PD, Truong-Tran AQ, Grosser D, Jayaran L, Murgia C, Ruffin RE. Zinc metabolism in airway epithelium: basic mechanisms and clinical targets. A review. Pharmacol Therapeut 2005; 105:127-49.
103. Leitzmann MF, Stampfer MJ, Wu K, Colditz GA, Willet WC, Giovannucci EL. Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst 2003; 95:1004-7.
104. Jarrard DF. Does zinc supplementation increase the risk of prostate cancer? JAMA 2005; 123: 102-3.
105. Johnson BJ, Ress SR, Willcox P, et al. Clinical and immune responses of tuberculosis patients treated with low-dose IL-2 and multidrug therapy. Cytokines Mol Ther 1995; 1:185-96.