Acquisition of Fyn-selective SH3 domain ligands via a combinatorial library strategy

Chemistry and Biology

Volumn 12, Issue 8, 2005, Pages 905-912

  Li, Haishan ^a   Lawrence, David S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FYN PROTEIN, HUMAN; HYBRID PROTEIN; LIGAND; PEPTIDE; PEPTIDE LIBRARY; PROTEIN KINASE FYN;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CELL; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; METABOLISM; PROTEIN BINDING; SRC HOMOLOGY DOMAIN; SYNTHESIS;

AMINO ACID SEQUENCE; BINDING SITES; CELLS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; HUMANS; LIGANDS; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-FYN; RECOMBINANT FUSION PROTEINS; SRC HOMOLOGY DOMAINS;

EID: 23944445322     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2005.06.007     Document Type: Article

References (26)

1. A. Musacchio How SH3 domains recognize proline Adv. Protein Chem. 61 2002 211 268
2. B.J. Mayer SH3 domains: complexity in moderation J. Cell Sci. 114 2001 1253 1263
3. A. Zarrinpar, R.P. Bhattacharyya, and W.A. Lim The structure and function of proline recognition domains Sci. STKE 2003 2003 RE8
4. G. Cesareni, S. Panni, G. Nardelli, and L. Castagnoli Can we infer peptide recognition specificity mediated by SH3 domains? FEBS Lett. 513 2002 38 44
5. S. Feng, J.K. Chen, H. Yu, J.A. Simon, and S.L. Schreiber Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions Science 266 1994 1241 1247
6. W.H. Gmeiner, and D.A. Horita Implications of SH3 domain structure and dynamics for protein regulation and drug design Cell Biochem. Biophys. 35 2001 127 140
7. T.J. Boggon, and M.J. Eck Structure and regulation of Src family kinases Oncogene 23 2004 7918 7927
8. G. Posern, J. Zheng, B.S. Knudsen, C. Kardinal, K.B. Muller, J. Voss, T. Shishido, D. Cowburn, G. Cheng, and B. Wang Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G Oncogene 16 1998 1903 1912
9. B.S. Knudsen, J. Zheng, S.M. Feller, J.P. Mayer, S.K. Burrell, D. Cowburn, and H. Hanafusa Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins EMBO J. 14 1995 2191 2198
10. S. Feng, T.M. Kapoor, F. Shirai, A.P. Combs, and S.L. Schreiber Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis Chem. Biol. 3 1996 661 670
11. M.T. Pisabarro, and L. Serrano Rational design of specific high-affinity peptide ligands for the Abl-SH3 domain Biochemistry 35 1996 10634 10640
12. E.H. Palacios, and A. Weiss Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation Oncogene 23 2004 7990 8000
13. S. Banin, O. Truong, D.R. Katz, M.D. Waterfield, P.M. Brickell, and I. Gout Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases Curr. Biol. 6 1996 981 988
14. J.T. Nguyen, C.W. Turck, F.E. Cohen, R.N. Zuckermann, and W.A. Lim Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors Science 282 1998 2088 2092
15. J.T. Nguyen, M. Porter, M. Amoui, W.T. Miller, R.N. Zuckermann, and W.A. Lim Improving SH3 domain ligand selectivity using a non-natural scaffold Chem. Biol. 7 2000 463 473
16. J.M. Borreguero, N.V. Dokholyan, S.V. Buldyrev, E.I. Shakhnovich, and H.E. Stanley Thermodynamics and folding kinetics analysis of the SH3 domain from discrete molecular dynamics J. Mol. Biol. 318 2002 863 876
17. T.R. Lee, and D.S. Lawrence Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library J. Med. Chem. 42 1999 784 787
18. R.H. Yeh, T.R. Lee, and D.S. Lawrence From consensus sequence peptide to high affinity ligand, a "library scan" strategy J. Biol. Chem. 276 2001 12235 12240
19. J.H. Lee, S.K. Nandy, and D.S. Lawrence A highly potent and selective PKCalpha inhibitor generated via combinatorial modification of a peptide scaffold J. Am. Chem. Soc. 126 2004 3394 3395
20. K. Shen, Y.F. Keng, L. Wu, X.L. Guo, D.S. Lawrence, and Z.Y. Zhang Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure J. Biol. Chem. 276 2001 47311 47319
21. K.W. Plaxco, J.I. Guijarro, C.J. Morton, M. Pitkeathly, I.D. Campbell, and C.M. Dobson The folding kinetics and thermodynamics of the Fyn-SH3 domain Biochemistry 37 1998 2529 2537
22. J. Gu, and X. Gu Natural history and functional divergence of protein tyrosine kinases Gene 317 2003 49 57
23. K. Badour, J. Zhang, F. Shi, Y. Leng, M. Collins, and K.A. Siminovitch Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation J. Exp. Med. 199 2004 99 112
24. M.P. Scott, F. Zappacosta, E.Y. Kim, R.S. Annan, and W.T. Miller Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 J. Biol. Chem. 277 2002 28238 28246
25. H. Schwende, E. Fitzke, P. Ambs, and P. Dieter Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25-dihydroxyvitamin D3 J. Leukoc. Biol. 59 1996 555 561
26. A.D. Morley Optimisation and synthesis of libraries derived from phenolic amino acid scaffolds Tetrahedron Lett. 41 2000 7405 7408