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Volumn 5, Issue 8, 2005, Pages 1039-1049

Gene therapy of mesothelioma

Author keywords

Cytokines; Intratumoural delivery; Suicide gene therapy; Viral vectors

Indexed keywords

ADENOVIRUS VECTOR; CYTOKINE; CYTOSINE DEAMINASE; DNA VACCINE; FLUCYTOSINE; GANCICLOVIR; HERPESVIRUS VECTOR; INTERLEUKIN 12; INTERLEUKIN 2; LENTIVIRUS VECTOR; LIPOSOME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PARVOVIRUS VECTOR; PROTEIN P16INK4A; PROTEIN P53; RECOMBINANT DNA; RETROVIRUS VECTOR; THYMIDINE KINASE;

EID: 23844558590     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.5.8.1039     Document Type: Review
Times cited : (5)

References (101)
  • 1
    • 84910467774 scopus 로고
    • Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province
    • WAGNER JC, SLEGGS CA, MARCHAND P: Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province. Br. J. Ind. Med. (1960) 17:260-271.
    • (1960) Br. J. Ind. Med. , vol.17 , pp. 260-271
    • Wagner, J.C.1    Sleggs, C.A.2    Marchand, P.3
  • 2
    • 3142751125 scopus 로고    scopus 로고
    • Epidemiology of malignant mesothelioma in Australia
    • MUSK AW, DE KLERK NH: Epidemiology of malignant mesothelioma in Australia. Lung Cancer (2004) 45(Suppl. 1):S21-S23.
    • (2004) Lung Cancer , vol.45 , Issue.SUPPL. 1
    • Musk, A.W.1    De Klerk, N.H.2
  • 4
    • 0029151788 scopus 로고
    • Malignant mesothelioma: New insights into tumour biology and immunology as a basis for new treatment approaches
    • UPHAM JW, GARLEPP MJ, MUSK AW, ROBINSON BW: Malignant mesothelioma: new insights into tumour biology and immunology as a basis for new treatment approaches. Thorax (1995) 50:887-893.
    • (1995) Thorax , vol.50 , pp. 887-893
    • Upham, J.W.1    Garlepp, M.J.2    Musk, A.W.3    Robinson, B.W.4
  • 5
    • 16244362744 scopus 로고    scopus 로고
    • Chemotherapy options and new advances in malignant pleural mesothelioma
    • STEELE JP, KLABATSA A: Chemotherapy options and new advances in malignant pleural mesothelioma. Ann. Oncol. (2005) 16:345-351.
    • (2005) Ann. Oncol. , vol.16 , pp. 345-351
    • Steele, J.P.1    Klabatsa, A.2
  • 6
    • 4744375249 scopus 로고    scopus 로고
    • Multimodality therapy in mesothelioma: Role of chemotherapy
    • VOGELZANG NJ: Multimodality therapy in mesothelioma: role of chemotherapy. Thorac. Surg. Clin. (2004) 14:531-542.
    • (2004) Thorac. Surg. Clin. , vol.14 , pp. 531-542
    • Vogelzang, N.J.1
  • 7
    • 4644235737 scopus 로고    scopus 로고
    • The palliative benefits of MVP (mitomycin C, vinblastine and cisplatin) chemotherapy in patients with malignant mesothelioma
    • ANDREOPOULOU E, ROSS PJ, O'BRIEN ME et al.: The palliative benefits of MVP (mitomycin C, vinblastine and cisplatin) chemotherapy in patients with malignant mesothelioma. Ann. Oncol. (2004) 15:1406-1412.
    • (2004) Ann. Oncol. , vol.15 , pp. 1406-1412
    • Andreopoulou, E.1    Ross, P.J.2    O'Brien, M.E.3
  • 8
    • 0026683592 scopus 로고
    • Wittenoom, Western Australia: A modern industrial disaster
    • MUSK AW, DE KLERK NH, ECCLES JL et al.: Wittenoom, Western Australia: a modern industrial disaster. Am. J. Ind. Med. (1992) 21:735-747.
    • (1992) Am. J. Ind. Med. , vol.21 , pp. 735-747
    • Musk, A.W.1    De Klerk, N.H.2    Eccles, J.L.3
  • 9
    • 0022485359 scopus 로고
    • Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy
    • MOOLTEN FL: Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res. (1986) 46:5276-5281.
    • (1986) Cancer Res. , vol.46 , pp. 5276-5281
    • Moolten, F.L.1
  • 10
    • 0025241769 scopus 로고
    • Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors
    • MOOLTEN FL, WELLS JM: Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J. Natl. Cancer Inst. (1990) 82:297-300.
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 297-300
    • Moolten, F.L.1    Wells, J.M.2
  • 11
    • 0028094693 scopus 로고
    • Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: An approach for specific in vivo donor T-cell depletion after bone marrow transplantation?
    • TIBERGHIEN P, REYNOLDS CW, KELLER J et al.: Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: an approach for specific in vivo donor T-cell depletion after bone marrow transplantation? Blood (1994) 84:1333-1341.
    • (1994) Blood , vol.84 , pp. 1333-1341
    • Tiberghien, P.1    Reynolds, C.W.2    Keller, J.3
  • 12
    • 0019299220 scopus 로고
    • The chemotherapeutic exploitation of virus-specified enzymes
    • ELION GB: The chemotherapeutic exploitation of virus-specified enzymes. Adv. Enzyme Regul. (1980) 18:53-66.
    • (1980) Adv. Enzyme Regul. , vol.18 , pp. 53-66
    • Elion, G.B.1
  • 14
    • 0027483695 scopus 로고
    • The 'bystander effect': Tumor regression when a fraction of the tumor mass is genetically modified
    • FREEMAN SM, ABBOUD CN, WHARTENBY KA et al.: The 'bystander effect': tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. (1993) 53:5274-5283.
    • (1993) Cancer Res. , vol.53 , pp. 5274-5283
    • Freeman, S.M.1    Abboud, C.N.2    Whartenby, K.A.3
  • 15
    • 0028795075 scopus 로고
    • In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine
    • HIRSCHOWITZ EA, OHWADA A, PASCAL WR, RUSSI TJ, CRYSTAL RG: In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine. Hum. Gene Ther. (1995) 6:1055-1063.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 1055-1063
    • Hirschowitz, E.A.1    Ohwada, A.2    Pascal, W.R.3    Russi, T.J.4    Crystal, R.G.5
  • 16
    • 0030046154 scopus 로고    scopus 로고
    • Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene
    • ELSHAMI AA, KUCHARCZUK JC, ZHANG HB et al.: Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene. Hum. Gene Ther. (1996) 7:141-148.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 141-148
    • Elshami, A.A.1    Kucharczuk, J.C.2    Zhang, H.B.3
  • 17
    • 0030742974 scopus 로고    scopus 로고
    • The role of the bystander effect in suicide gene therapy
    • POPE IM, POSTON GJ, KINSELLA AR: The role of the bystander effect in suicide gene therapy. Eur. J. Cancer (1997) 33:1005-1016.
    • (1997) Eur. J. Cancer , vol.33 , pp. 1005-1016
    • Pope, I.M.1    Poston, G.J.2    Kinsella, A.R.3
  • 18
    • 0028776416 scopus 로고
    • Successful gene therapy has researchers looking for the bystander effect
    • SEACHRIST L: Successful gene therapy has researchers looking for the bystander effect. J. Natl. Cancer Inst. (1994) 86:82-83.
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 82-83
    • Seachrist, L.1
  • 19
    • 0029997766 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells
    • HAMEL W, MAGNELLI L, CHIARUGI VP, ISRAEL MA: Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res. (1996) 56:2697-2702.
    • (1996) Cancer Res. , vol.56 , pp. 2697-2702
    • Hamel, W.1    Magnelli, L.2    Chiarugi, V.P.3    Israel, M.A.4
  • 20
    • 16944364591 scopus 로고    scopus 로고
    • Safety of intrapleurally administered recombinant adenovirus carrying herpes simplex thymidine kinase DNA followed by ganciclovir therapy in nonhuman primates
    • KUCHARCZUK JC, RAPER S, ELSHAMI AA et al.: Safety of intrapleurally administered recombinant adenovirus carrying herpes simplex thymidine kinase DNA followed by ganciclovir therapy in nonhuman primates. Hum. Gene Ther. (1996) 7:2225-2233.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 2225-2233
    • Kucharczuk, J.C.1    Raper, S.2    Elshami, A.A.3
  • 21
    • 0033540353 scopus 로고    scopus 로고
    • Evaluation of an E1E4-deleted adenovirus expressing the herpes simplex thymidine kinase suicide gene in cancer gene therapy
    • LANUTI M, GAO GP, FORCE SD et al.: Evaluation of an E1E4-deleted adenovirus expressing the herpes simplex thymidine kinase suicide gene in cancer gene therapy. Hum. Gene Ther. (1999) 10:463-475.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 463-475
    • Lanuti, M.1    Gao, G.P.2    Force, S.D.3
  • 22
    • 0030936116 scopus 로고    scopus 로고
    • Gene therapy of experimental malignant mesothelioma using adenovirus vectors encoding the HSVtk gene
    • ESANDI MC, VAN SOMEREN GD, VINCENT AJ et al.: Gene therapy of experimental malignant mesothelioma using adenovirus vectors encoding the HSVtk gene. Gene Ther. (1997) 4:280-287.
    • (1997) Gene Ther. , vol.4 , pp. 280-287
    • Esandi, M.C.1    Van Someren, G.D.2    Vincent, A.J.3
  • 23
    • 0028340984 scopus 로고
    • Successful adenovirus-mediated gene transfer in an in vivo model of human malignant mesothelioma
    • SMYTHE WR, KAISER LR, HWANG HC et al.: Successful adenovirus-mediated gene transfer in an in vivo model of human malignant mesothelioma. Ann. Thorac. Surg. (1994) 57:1395-1401.
    • (1994) Ann. Thorac. Surg. , vol.57 , pp. 1395-1401
    • Smythe, W.R.1    Kaiser, L.R.2    Hwang, H.C.3
  • 24
    • 0028348372 scopus 로고
    • Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: An effective in vitro drug sensitization system
    • SMYTHE WR, HWANG HC, AMIN KM et al.: Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system. Cancer Res. (1994) 54:2055-2059.
    • (1994) Cancer Res. , vol.54 , pp. 2055-2059
    • Smythe, W.R.1    Hwang, H.C.2    Amin, K.M.3
  • 25
    • 0029076201 scopus 로고
    • Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene
    • SMYTHE WR, HWANG HC, ELSHAMI AA et al.: Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene. Ann. Surg. (1995) 222:78-86.
    • (1995) Ann. Surg. , vol.222 , pp. 78-86
    • Smythe, W.R.1    Hwang, H.C.2    Elshami, A.A.3
  • 26
    • 0029340302 scopus 로고
    • Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer
    • HWANG HC, SMYTHE WR, ELSHAMI AA et al.: Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer. Am. J. Respir. Cell Mol. Biol. (1995) 13:7-16.
    • (1995) Am. J. Respir. Cell Mol. Biol. , vol.13 , pp. 7-16
    • Hwang, H.C.1    Smythe, W.R.2    Elshami, A.A.3
  • 27
    • 0029799294 scopus 로고    scopus 로고
    • Treatment of advanced mesothelioma with the recombinant adenovirus H5.010RSVTK: A Phase I trial (BB-IND 6274)
    • TREAT J, KAISER LR, STERMAN DH et al.: Treatment of advanced mesothelioma with the recombinant adenovirus H5.010RSVTK: a Phase I trial (BB-IND 6274). Hum. Gene Ther. (1996) 7:2047-2057.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 2047-2057
    • Treat, J.1    Kaiser, L.R.2    Sterman, D.H.3
  • 28
    • 17344365922 scopus 로고    scopus 로고
    • Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: Results of a Phase I clinical trial in malignant mesothelioma
    • STERMAN DH, TREAT J, LITZKY LA et al.: Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a Phase I clinical trial in malignant mesothelioma. Hum. Gene Ther. (1998) 9:1083-1092.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 1083-1092
    • Sterman, D.H.1    Treat, J.2    Litzky, L.A.3
  • 29
    • 17344366044 scopus 로고    scopus 로고
    • Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy Phase I clinical trial for localized mesothelioma
    • MOLNAR-KIMBER KL, STERMAN DH, CHANG M et al.: Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy Phase I clinical trial for localized mesothelioma. Hum. Gene Ther. (1998) 9:2121-2133.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 2121-2133
    • Molnar-Kimber, K.L.1    Sterman, D.H.2    Chang, M.3
  • 30
    • 0026642375 scopus 로고
    • Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions
    • TAKAHASHI T, CARBONE D, NAU MM et al.: Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions. Cancer Res. (1992) 52:2340-2343.
    • (1992) Cancer Res. , vol.52 , pp. 2340-2343
    • Takahashi, T.1    Carbone, D.2    Nau, M.M.3
  • 31
    • 0026682649 scopus 로고
    • p53 and Kirsten-ras mutations in human mesothelioma cell lines
    • METCALF RA, WELSH JA, BENNETT WP et al.: p53 and Kirsten-ras mutations in human mesothelioma cell lines. Cancer Res. (1992) 52:2610-2615.
    • (1992) Cancer Res. , vol.52 , pp. 2610-2615
    • Metcalf, R.A.1    Welsh, J.A.2    Bennett, W.P.3
  • 32
  • 33
    • 0035106011 scopus 로고    scopus 로고
    • SV40 and cell cycle perturbations in malignant mesothelioma
    • TESTA JR, GIORDANO A: SV40 and cell cycle perturbations in malignant mesothelioma. Semin. Cancer Biol. (2001) 11:31-38.
    • (2001) Semin. Cancer Biol. , vol.11 , pp. 31-38
    • Testa, J.R.1    Giordano, A.2
  • 34
    • 0036837992 scopus 로고    scopus 로고
    • Inactivation of p16INK4a expression in malignant mesothelioma by methylation
    • WONG L, ZHOU J, ANDERSON D, KRATZKE RA: Inactivation of p16INK4a expression in malignant mesothelioma by methylation. Lung Cancer (2002) 38:131-136.
    • (2002) Lung Cancer , vol.38 , pp. 131-136
    • Wong, L.1    Zhou, J.2    Anderson, D.3    Kratzke, R.A.4
  • 35
    • 0033664624 scopus 로고    scopus 로고
    • Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus
    • FRIZELLE SP, RUBINS JB, ZHOU JX, CURIEL DT, KRATZKE RA: Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus. Cancer Gene Ther. (2000) 7:1421-1425.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 1421-1425
    • Frizelle, S.P.1    Rubins, J.B.2    Zhou, J.X.3    Curiel, D.T.4    Kratzke, R.A.5
  • 36
    • 0035881594 scopus 로고    scopus 로고
    • p14(ARF) modulates the cytolytic effect of ONYX-015 in mesothelioma cells with wild-type p53
    • YANG CT, YOU L, UEMATSU K, YEH CC, MCCORMICK F, JABLONS DM: p14(ARF) modulates the cytolytic effect of ONYX-015 in mesothelioma cells with wild-type p53. Cancer Res. (2001) 61:5959-5963.
    • (2001) Cancer Res. , vol.61 , pp. 5959-5963
    • Yang, C.T.1    You, L.2    Uematsu, K.3    Yeh, C.C.4    Mccormick, F.5    Jablons, D.M.6
  • 38
    • 0031218470 scopus 로고    scopus 로고
    • Oncogenes and tumor-suppressor genes in mesothelioma-a synopsis
    • LECHNER JF, TESFAIGZI J, GERWIN BI: Oncogenes and tumor-suppressor genes in mesothelioma-a synopsis. Environ. Health Perspect. (1997) 105(Suppl. 5):1061-1067.
    • (1997) Environ. Health Perspect. , vol.105 , Issue.SUPPL. 5 , pp. 1061-1067
    • Lechner, J.F.1    Tesfaigzi, J.2    Gerwin, B.I.3
  • 39
    • 0035258783 scopus 로고    scopus 로고
    • Mutational analysis of N-ras, p53, p16INK4a, p14ARF, CDK4 genes in primary human malignant mesotheliomas
    • PAPP T, SCHIPPER H, PEMSEL H et al.: Mutational analysis of N-ras, p53, p16INK4a, p14ARF, CDK4 genes in primary human malignant mesotheliomas. Int. J. Oncol. (2001) 18:425-433.
    • (2001) Int. J. Oncol. , vol.18 , pp. 425-433
    • Papp, T.1    Schipper, H.2    Pemsel, H.3
  • 40
    • 0344405743 scopus 로고    scopus 로고
    • A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14ARF and p16INK4A) in human mesothelioma cells
    • YANG CT, YOU L, LIN YC, LIN CL, MCCORMICK F, JABLONS DM: A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14ARF and p16INK4A) in human mesothelioma cells. Anticancer Res. (2003) 23:33-38.
    • (2003) Anticancer Res. , vol.23 , pp. 33-38
    • Yang, C.T.1    You, L.2    Lin, Y.C.3    Lin, C.L.4    Mccormick, F.5    Jablons, D.M.6
  • 41
    • 0032543305 scopus 로고    scopus 로고
    • Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression
    • FRIZELLE SP, GRIM J, ZHOU J et al.: Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression. Oncogene (1998) 16:3087-3095.
    • (1998) Oncogene , vol.16 , pp. 3087-3095
    • Frizelle, S.P.1    Grim, J.2    Zhou, J.3
  • 42
    • 0035144922 scopus 로고    scopus 로고
    • Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines
    • PATAER A, SMYTHE WR, YU R et al.: Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J. Thorac. Cardiovasc. Surg. (2001) 121:61-67.
    • (2001) J. Thorac. Cardiovasc. Surg. , vol.121 , pp. 61-67
    • Pataer, A.1    Smythe, W.R.2    Yu, R.3
  • 43
    • 0034874520 scopus 로고    scopus 로고
    • Significant augmentation of pro-apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma
    • MOHIUDDIN I, CAO X, FANG B, NISHIZAKI M, SMYTHE WR: Significant augmentation of pro-apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma. Cancer Gene Ther. (2001) 8:547-554.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 547-554
    • Mohiuddin, I.1    Cao, X.2    Fang, B.3    Nishizaki, M.4    Smythe, W.R.5
  • 44
    • 0028691685 scopus 로고
    • Replicating vectors for cancer therapy: A question of strategy
    • RUSSELL SJ: Replicating vectors for cancer therapy: a question of strategy. Semin. Cancer Biol. (1994) 5:437-443.
    • (1994) Semin. Cancer Biol. , vol.5 , pp. 437-443
    • Russell, S.J.1
  • 45
    • 0032854872 scopus 로고    scopus 로고
    • Use of protamine to augment adenovirus-mediated cancer gene therapy
    • LANUTI M, KOURI CE, FORCE S et al.: Use of protamine to augment adenovirus-mediated cancer gene therapy. Gene Ther. (1999) 6:1600-1610.
    • (1999) Gene Ther. , vol.6 , pp. 1600-1610
    • Lanuti, M.1    Kouri, C.E.2    Force, S.3
  • 46
    • 0029154946 scopus 로고
    • The role of immunosuppression in the efficacy of cancer gene therapy using adenovirus transfer of the herpes simplex thymidine kinase gene
    • ELSHAMI AA, KUCHARCZUK JC, STERMAN DH et al.: The role of immunosuppression in the efficacy of cancer gene therapy using adenovirus transfer of the herpes simplex thymidine kinase gene. Ann. Surg. (1995) 222:298-307; 307-310.
    • (1995) Ann. Surg. , vol.222 , pp. 298-307
    • Elshami, A.A.1    Kucharczuk, J.C.2    Sterman, D.H.3
  • 47
    • 0028907485 scopus 로고
    • Differential sensitivity of thoracic malignant tumors to adenovirus-mediated drug sensitization gene therapy
    • discussion 630-631
    • SMYTHE WR, HWANG HC, ELSHAMI AA, AMIN KM, ALBELDA SM, KAISER LR: Differential sensitivity of thoracic malignant tumors to adenovirus-mediated drug sensitization gene therapy. J. Thorac. Cardiovasc. Surg. (1995) 109:626-630; discussion 630-631.
    • (1995) J. Thorac. Cardiovasc. Surg. , vol.109 , pp. 626-630
    • Smythe, W.R.1    Hwang, H.C.2    Elshami, A.A.3    Amin, K.M.4    Albelda, S.M.5    Kaiser, L.R.6
  • 48
    • 0035143515 scopus 로고    scopus 로고
    • Imaging in vivo herpes simplex virus thymidine kinase gene transfer to tumour-bearing rodents using positron emission tomography and
    • HUSTINX R, SHIUE CY, ALAVI A et al.: Imaging in vivo herpes simplex virus thymidine kinase gene transfer to tumour-bearing rodents using positron emission tomography and. Eur. J. Nucl. Med. (2001) 28:5-12.
    • (2001) Eur. J. Nucl. Med. , vol.28 , pp. 5-12
    • Hustinx, R.1    Shiue, C.Y.2    Alavi, A.3
  • 49
    • 0031052384 scopus 로고    scopus 로고
    • Use of a 'replication-restricted' herpes virus to treat experimental human malignant mesothelioma
    • KUCHARCZUK JC, RANDAZZO B, CHANG MY et al.: Use of a 'replication- restricted' herpes virus to treat experimental human malignant mesothelioma. Cancer Res. (1997) 57:466-471.
    • (1997) Cancer Res. , vol.57 , pp. 466-471
    • Kucharczuk, J.C.1    Randazzo, B.2    Chang, M.Y.3
  • 50
    • 0034106260 scopus 로고    scopus 로고
    • Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: Persistent transgene expression despite antibody generation
    • MUKHERJEE S, HAENEL T, HIMBECK R et al.: Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: persistent transgene expression despite antibody generation. Cancer Gene Ther. (2000) 7:663-670.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 663-670
    • Mukherjee, S.1    Haenel, T.2    Himbeck, R.3
  • 52
    • 0031924007 scopus 로고    scopus 로고
    • Cytokine gene therapy or infusion as treatment for solid human cancer
    • ROBINSON BW, MUKHERJEE SA, DAVIDSON A et al.: Cytokine gene therapy or infusion as treatment for solid human cancer. J. Immunother. (1998) 21:211-217.
    • (1998) J. Immunother. , vol.21 , pp. 211-217
    • Robinson, B.W.1    Mukherjee, S.A.2    Davidson, A.3
  • 53
    • 0036178251 scopus 로고    scopus 로고
    • New approaches for mesothelioma: Biologics, vaccines, gene therapy, and other novel agents
    • NOWAK AK, LAKE RA, KINDLER HL, ROBINSON BW: New approaches for mesothelioma: biologics, vaccines, gene therapy, and other novel agents. Semin. Oncol. (2002) 29:82-96.
    • (2002) Semin. Oncol. , vol.29 , pp. 82-96
    • Nowak, A.K.1    Lake, R.A.2    Kindler, H.L.3    Robinson, B.W.4
  • 55
    • 0031710567 scopus 로고    scopus 로고
    • Intralesional cytokine therapy in cancer: A pilot study of GM-CSF infusion in mesothelioma
    • DAVIDSON JA, MUSK AW, WOOD BR et al.: Intralesional cytokine therapy in cancer: a pilot study of GM-CSF infusion in mesothelioma. J. Immunother. (1998) 21:389-398.
    • (1998) J. Immunother. , vol.21 , pp. 389-398
    • Davidson, J.A.1    Musk, A.W.2    Wood, B.R.3
  • 56
    • 0026520154 scopus 로고
    • IL-2 Phase II trial in metastatic melanoma: Analysis of clinical and immunological parameters
    • DORVAL T, MATHIOT C, CHOSIDOW O et al.: IL-2 Phase II trial in metastatic melanoma: analysis of clinical and immunological parameters. Biotechnol. Ther. (1992) 3:63-79.
    • (1992) Biotechnol. Ther. , vol.3 , pp. 63-79
    • Dorval, T.1    Mathiot, C.2    Chosidow, O.3
  • 58
    • 0036795030 scopus 로고    scopus 로고
    • Ad-IFN gamma induces antiproliferative and antitumoral responses in malignant mesothelioma
    • GATTACCECA F, PILATTE Y, BILLARD C et al.: Ad-IFN gamma induces antiproliferative and antitumoral responses in malignant mesothelioma. Clin. Cancer Res. (2002) 8:3298-3304.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3298-3304
    • Gattacceca, F.1    Pilatte, Y.2    Billard, C.3
  • 60
    • 10744230328 scopus 로고    scopus 로고
    • Immuno-gene therapy with interferon-beta before surgical debulking delays recurrence and improves survival in a murine model of malignant mesothelioma
    • KRUKLITIS RJ, SINGHAL S, DELONG P et al.: Immuno-gene therapy with interferon-beta before surgical debulking delays recurrence and improves survival in a murine model of malignant mesothelioma. J. Thorac. Cardiovasc. Surg. (2004) 127:123-130.
    • (2004) J. Thorac. Cardiovasc. Surg. , vol.127 , pp. 123-130
    • Kruklitis, R.J.1    Singhal, S.2    Delong, P.3
  • 61
    • 0036664630 scopus 로고    scopus 로고
    • Analysis of the immunologic response generated by Ad.IFN-beta during successful intraperitoneal tumor gene therapy
    • ODAKA M, WIEWRODT R, DELONG P et al.: Analysis of the immunologic response generated by Ad.IFN-beta during successful intraperitoneal tumor gene therapy. Mol. Ther. (2002) 6:210-218.
    • (2002) Mol. Ther. , vol.6 , pp. 210-218
    • Odaka, M.1    Wiewrodt, R.2    Delong, P.3
  • 63
    • 0025095664 scopus 로고
    • Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response
    • FEARON ER, PARDOLL DM, ITAYA T et al.: Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell (1990) 60:397-403.
    • (1990) Cell , vol.60 , pp. 397-403
    • Fearon, E.R.1    Pardoll, D.M.2    Itaya, T.3
  • 64
    • 0026331269 scopus 로고
    • Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4
    • GOLUMBEK PT, LAZENBY AJ, LEVITSKY HI et al.: Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science (1991) 254:713-716.
    • (1991) Science , vol.254 , pp. 713-716
    • Golumbek, P.T.1    Lazenby, A.J.2    Levitsky, H.I.3
  • 65
    • 0025806563 scopus 로고
    • Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors
    • ASHER AL, MULE JJ, KASID A et al.: Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors. J. Immunol. (1991) 146:3227-3234.
    • (1991) J. Immunol. , vol.146 , pp. 3227-3234
    • Asher, A.L.1    Mule, J.J.2    Kasid, A.3
  • 66
    • 0034100896 scopus 로고    scopus 로고
    • Regression of human metastatic renal cell carcinoma after vaccination with tumor cell-dendritic cell hybrids
    • KUGLER A, STUHLER G, WALDEN P et al.: Regression of human metastatic renal cell carcinoma after vaccination with tumor cell-dendritic cell hybrids. Nat. Med. (2000) 6:332-336.
    • (2000) Nat. Med. , vol.6 , pp. 332-336
    • Kugler, A.1    Stuhler, G.2    Walden, P.3
  • 67
    • 0030916031 scopus 로고    scopus 로고
    • Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma
    • LEONG CC, MARLEY JV, LOH S, MILECH N, ROBINSON BW, GARLEPP MJ: Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma. Int. J. Cancer (1997) 71:476-482.
    • (1997) Int. J. Cancer , vol.71 , pp. 476-482
    • Leong, C.C.1    Marley, J.V.2    Loh, S.3    Milech, N.4    Robinson, B.W.5    Garlepp, M.J.6
  • 68
    • 0034868843 scopus 로고    scopus 로고
    • The immune anti-tumor effects of GM-CSF, B7-1 gene transfection are enhanced by surgical debulking of tumor
    • MUKHERJEE S, NELSON D, LOH S et al.: The immune anti-tumor effects of GM-CSF, B7-1 gene transfection are enhanced by surgical debulking of tumor. Cancer Gene Ther. (2001) 8:580-588.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 580-588
    • Mukherjee, S.1    Nelson, D.2    Loh, S.3
  • 69
    • 0032553648 scopus 로고    scopus 로고
    • The treatment of malignant mesothelioma with a gene modified cancer cell line: A Phase I study
    • SCHWARZENBERGER P, HARRISON L, WEINACKER A et al.: The treatment of malignant mesothelioma with a gene modified cancer cell line: a Phase I study. Hum. Gene Ther. (1998) 9:2641-2649.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 2641-2649
    • Schwarzenberger, P.1    Harrison, L.2    Weinacker, A.3
  • 70
    • 0032133392 scopus 로고    scopus 로고
    • Antitumor activity with the HSV-tk-gene-modified cell line PA-1-STK in malignant mesothelioma
    • SCHWARZENBERGER P, LEI D, FREEMAN SM et al.: Antitumor activity with the HSV-tk-gene-modified cell line PA-1-STK in malignant mesothelioma. Am. J. Respir. Cell Mol. Biol. (1998) 19:333-337.
    • (1998) Am. J. Respir. Cell Mol. Biol. , vol.19 , pp. 333-337
    • Schwarzenberger, P.1    Lei, D.2    Freeman, S.M.3
  • 72
    • 0033117849 scopus 로고    scopus 로고
    • Interleukin 2 (IL-2) therapy: Potential advantages of locoregional versus systemic administration
    • BERNSEN MR, TANG JW, EVERSE LA, KOTEN JW, OTTER WD: Interleukin 2 (IL-2) therapy: potential advantages of locoregional versus systemic administration. Cancer Treat. Rev. (1999) 25:73-82.
    • (1999) Cancer Treat. Rev. , vol.25 , pp. 73-82
    • Bernsen, M.R.1    Tang, J.W.2    Everse, L.A.3    Koten, J.W.4    Otter, W.D.5
  • 73
    • 0035248115 scopus 로고    scopus 로고
    • Phase I clinical trial of interleukin 2 (IL-2) gene therapy for prostate cancer
    • PANTUCK AJ, BELLDEGRUN AS: Phase I clinical trial of interleukin 2 (IL-2) gene therapy for prostate cancer. Curr. Urol. Rep. (2001) 2:33.
    • (2001) Curr. Urol. Rep. , vol.2 , pp. 33
    • Pantuck, A.J.1    Belldegrun, A.S.2
  • 74
    • 0033665927 scopus 로고    scopus 로고
    • Phase I clinical trial with IL-2-transfected xenogeneic cells administered in subcutaneous metastatic tumours: Clinical and immunological findings
    • TARTOUR E, MEHTALI M, SASTRE-GARAU X et al.: Phase I clinical trial with IL-2-transfected xenogeneic cells administered in subcutaneous metastatic tumours: clinical and immunological findings. Br. J. Cancer (2000) 83:1454-1461.
    • (2000) Br. J. Cancer , vol.83 , pp. 1454-1461
    • Tartour, E.1    Mehtali, M.2    Sastre-Garau, X.3
  • 75
    • 0035139422 scopus 로고    scopus 로고
    • Palliative and therapeutic activity of IL-2 immunotherapy in unresectable malignant pleural mesothelioma with pleural effusion: Results of a Phase II study on 31 consecutive patients
    • CASTAGNETO B, ZAI S, MUTTI L et al.: Palliative and therapeutic activity of IL-2 immunotherapy in unresectable malignant pleural mesothelioma with pleural effusion: results of a Phase II study on 31 consecutive patients. Lung Cancer (2001) 31:303-310.
    • (2001) Lung Cancer , vol.31 , pp. 303-310
    • Castagneto, B.1    Zai, S.2    Mutti, L.3
  • 76
    • 0035881733 scopus 로고    scopus 로고
    • Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon-beta gene therapy is attributable to induction of systemic immunity
    • ODAKA M, STERMAN DH, WIEWRODT R et al.: Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon-beta gene therapy is attributable to induction of systemic immunity. Cancer Res. (2001) 61:6201-6212.
    • (2001) Cancer Res. , vol.61 , pp. 6201-6212
    • Odaka, M.1    Sterman, D.H.2    Wiewrodt, R.3
  • 77
    • 18344398322 scopus 로고    scopus 로고
    • Cationic lipid:bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models
    • LANUTI M, RUDGINSKY S, FORCE SD et al.: Cationic lipid:bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models. Cancer Res. (2000) 60:2955-2963.
    • (2000) Cancer Res. , vol.60 , pp. 2955-2963
    • Lanuti, M.1    Rudginsky, S.2    Force, S.D.3
  • 79
    • 0028857559 scopus 로고
    • Recent advances in the study of dendritic cells and follicular dendritic cells
    • CAUX C, LIU YJ, BANCHEREAU J: Recent advances in the study of dendritic cells and follicular dendritic cells. Immunol. Today (1995) 16:2-4.
    • (1995) Immunol. Today , vol.16 , pp. 2-4
    • Caux, C.1    Liu, Y.J.2    Banchereau, J.3
  • 80
    • 0025735629 scopus 로고
    • The dendritic cell system and its role in immunogenicity
    • STEINMAN RM: The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. (1991) 9:271-296.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 271-296
    • Steinman, R.M.1
  • 81
    • 0030639411 scopus 로고    scopus 로고
    • A comparison of gene transfer methods in human dendritic cells
    • ARTHUR JF, BUTTERFIELD LH, ROTH MD et al.: A comparison of gene transfer methods in human dendritic cells. Cancer Gene Ther. (1997) 4:17-25.
    • (1997) Cancer Gene Ther. , vol.4 , pp. 17-25
    • Arthur, J.F.1    Butterfield, L.H.2    Roth, M.D.3
  • 82
    • 2642679384 scopus 로고    scopus 로고
    • Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: Enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-alpha
    • TUTING T, WILSON CC, MARTIN DM et al.: Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-alpha. J. Immunol. (1998) 160:1139-1147.
    • (1998) J. Immunol. , vol.160 , pp. 1139-1147
    • Tuting, T.1    Wilson, C.C.2    Martin, D.M.3
  • 83
    • 0031941423 scopus 로고    scopus 로고
    • Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
    • NESTLE FO, ALIJAGIC S, GILLIET M et al.: Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat. Med. (1998) 4:328-332.
    • (1998) Nat. Med. , vol.4 , pp. 328-332
    • Nestle, F.O.1    Alijagic, S.2    Gilliet, M.3
  • 84
    • 0042232462 scopus 로고    scopus 로고
    • Dendritic cells infected with a vaccinia virus interleukin-2 vector secrete high levels of IL-2 and can become efficient antigen presenting cells that secrete high levels of the immunostimulatory cytokine IL-12
    • MUKHERJEE S, UPHAM J, RAMSHAW I, ROBINSON BW, NELSON DJ: Dendritic cells infected with a vaccinia virus interleukin-2 vector secrete high levels of IL-2 and can become efficient antigen presenting cells that secrete high levels of the immunostimulatory cytokine IL-12. Cancer Gene Ther. (2003) 10:591-602.
    • (2003) Cancer Gene Ther. , vol.10 , pp. 591-602
    • Mukherjee, S.1    Upham, J.2    Ramshaw, I.3    Robinson, B.W.4    Nelson, D.J.5
  • 85
    • 0035289225 scopus 로고    scopus 로고
    • Alphavirus vectors: Development and potential therapeutic applications
    • SCHLESINGER S: Alphavirus vectors: development and potential therapeutic applications. Expert Opin. Biol. Ther. (2001) 1:177-191.
    • (2001) Expert Opin. Biol. Ther. , vol.1 , pp. 177-191
    • Schlesinger, S.1
  • 86
    • 0033028791 scopus 로고    scopus 로고
    • Cancer therapy using a self-replicating RNA vaccine
    • YING H, ZAKS T, WANG R et al.: Cancer therapy using a self-replicating RNA vaccine. Nat. Med. (1999) 5:823-827.
    • (1999) Nat. Med. , vol.5 , pp. 823-827
    • Ying, H.1    Zaks, T.2    Wang, R.3
  • 87
    • 0036533543 scopus 로고    scopus 로고
    • Immunotherapy with recombinant SFV-replicons expressing the P815A tumor antigen or IL-12 induces tumor regression
    • COLMENERO P, CHEN M, CASTANOS-VELEZ E, LILJESTROM P, JONDAL M: Immunotherapy with recombinant SFV-replicons expressing the P815A tumor antigen or IL-12 induces tumor regression. Int. J. Cancer (2002) 98:554-560.
    • (2002) Int. J. Cancer , vol.98 , pp. 554-560
    • Colmenero, P.1    Chen, M.2    Castanos-Velez, E.3    Liljestrom, P.4    Jondal, M.5
  • 88
    • 4644337717 scopus 로고    scopus 로고
    • Potent tumor-specific immunity induced by an in vivo heat shock protein-suicide gene-based tumor vaccine
    • REN W, STRUBE R, ZHANG X, CHEN SY, HUANG XF: Potent tumor-specific immunity induced by an in vivo heat shock protein-suicide gene-based tumor vaccine. Cancer Res. (2004) 64:6645-6651.
    • (2004) Cancer Res. , vol.64 , pp. 6645-6651
    • Ren, W.1    Strube, R.2    Zhang, X.3    Chen, S.Y.4    Huang, X.F.5
  • 89
    • 1642538454 scopus 로고    scopus 로고
    • Dendritic cells transfected with cytopathic self-replicating RNA induce crosspriming of CD8+ T cells and antiviral immunity
    • RACANELLI V, BEHRENS SE, ALIBERTI J, REHERMANN B: Dendritic cells transfected with cytopathic self-replicating RNA induce crosspriming of CD8+ T cells and antiviral immunity. Immunity (2004) 20:47-58.
    • (2004) Immunity , vol.20 , pp. 47-58
    • Racanelli, V.1    Behrens, S.E.2    Aliberti, J.3    Rehermann, B.4
  • 90
    • 0031870247 scopus 로고    scopus 로고
    • Trans-complementation of flavivirus RNA polymerase gene NS5 by using Kunjin virus replicon-expressing BHK cells
    • KHROMYKH AA, KENNEY MT, WESTAWAY EG: Trans-complementation of flavivirus RNA polymerase gene NS5 by using Kunjin virus replicon-expressing BHK cells. J. Virol. (1998) 72:7270-7279.
    • (1998) J. Virol. , vol.72 , pp. 7270-7279
    • Khromykh, A.A.1    Kenney, M.T.2    Westaway, E.G.3
  • 92
    • 0037236237 scopus 로고    scopus 로고
    • Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways
    • LEITNER WW, HWANG LN, DEVEER MJ et al.: Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways. Nat. Med. (2003) 9:33-39.
    • (2003) Nat. Med. , vol.9 , pp. 33-39
    • Leitner, W.W.1    Hwang, L.N.2    Deveer, M.J.3
  • 93
    • 0035077790 scopus 로고    scopus 로고
    • Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen
    • HSU KF, HUNG CF, CHENG WF et al.: Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen. Gene Ther. (2001) 8:376-383.
    • (2001) Gene Ther. , vol.8 , pp. 376-383
    • Hsu, K.F.1    Hung, C.F.2    Cheng, W.F.3
  • 94
    • 0033955167 scopus 로고    scopus 로고
    • Enhancement of tumor-specific immune response with plasmid DNA replicon vectors
    • LEITNER WW, YING H, DRIVER DA, DUBENSKY TW, RESTIFO NP: Enhancement of tumor-specific immune response with plasmid DNA replicon vectors. Cancer Res. (2000) 60:51-55.
    • (2000) Cancer Res. , vol.60 , pp. 51-55
    • Leitner, W.W.1    Ying, H.2    Driver, D.A.3    Dubensky, T.W.4    Restifo, N.P.5
  • 95
    • 0035374861 scopus 로고    scopus 로고
    • Vaccines to die for
    • RESTIFO NP: Vaccines to die for. Nat. Biotechnol. (2001) 19:527-528.
    • (2001) Nat. Biotechnol. , vol.19 , pp. 527-528
    • Restifo, N.P.1
  • 96
    • 0034681126 scopus 로고    scopus 로고
    • Cationic microparticles: A potent delivery system for DNA vaccines
    • SINGH M, BRIONES M, OTT G, O'HAGAN D: Cationic microparticles: a potent delivery system for DNA vaccines. Proc. Natl. Acad. Sci. USA (2000) 97:811-816.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 811-816
    • Singh, M.1    Briones, M.2    Ott, G.3    O'Hagan, D.4
  • 98
    • 0033586301 scopus 로고    scopus 로고
    • Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection
    • DIEBOLD SS, LEHRMANN H, KURSA M, WAGNER E, COTTEN M, ZENKE M: Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection. Hum. Gene Ther. (1999) 10:775-786.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 775-786
    • Diebold, S.S.1    Lehrmann, H.2    Kursa, M.3    Wagner, E.4    Cotten, M.5    Zenke, M.6
  • 99
    • 0037405146 scopus 로고    scopus 로고
    • Attenuated Salmonella enterica serovar Typhi and Shigella flexneri 2a strains mucosally deliver DNA vaccines encoding measles virus hemagglutinin, inducing specific immune responses and protection in cotton rats
    • PASETTI MF, BARRY EM, LOSONSKY G et al.: Attenuated Salmonella enterica serovar Typhi and Shigella flexneri 2a strains mucosally deliver DNA vaccines encoding measles virus hemagglutinin, inducing specific immune responses and protection in cotton rats. J. Virol. (2003) 77:5209-5217.
    • (2003) J. Virol. , vol.77 , pp. 5209-5217
    • Pasetti, M.F.1    Barry, E.M.2    Losonsky, G.3
  • 100
    • 18244397981 scopus 로고    scopus 로고
    • Clinical and immunological assessment of Mycobacterium vaccae (SRL172) with chemotherapy in patients with malignant mesothelioma
    • MENDES R, O'BRIEN ME, MITRA A et al.: Clinical and immunological assessment of Mycobacterium vaccae (SRL172) with chemotherapy in patients with malignant mesothelioma. Br. J. Cancer (2002) 86:336-341.
    • (2002) Br. J. Cancer , vol.86 , pp. 336-341
    • Mendes, R.1    O'Brien, M.E.2    Mitra, A.3
  • 101
    • 0035083654 scopus 로고    scopus 로고
    • Cutaneous toxicity after intradermal vaccination with Mycobacterium vaccae against lung cancer and malignant mesothelioma
    • PANDHA HS, MORTIMER P, SOUBERBEILLE B, MCCOUBRIE P, O'BRIEN ME: Cutaneous toxicity after intradermal vaccination with Mycobacterium vaccae against lung cancer and malignant mesothelioma. Br. J. Dermatol. (2001) 144:648-649.
    • (2001) Br. J. Dermatol. , vol.144 , pp. 648-649
    • Pandha, H.S.1    Mortimer, P.2    Souberbeille, B.3    Mccoubrie, P.4    O'Brien, M.E.5


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