SV40 and cell cycle perturbations in malignant mesothelioma

Seminars in Cancer Biology

Volumn 11, Issue 1, 2001, Pages 31-38

  Testa, Joseph R ^a   Giordano, Antonio ^b  

^a FOX CHASE CANCER CENTER   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Cell cycle deregulation; p14ARF; p16INK4a; p53; SV40; Tumor suppressor gene products pRb

Indexed keywords

ONCOPROTEIN; PROTEIN P14 ARF; PROTEIN P16INK4A; PROTEIN P53; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; CELL CYCLE; CYTOGENETICS; DNA DAMAGE; HUMAN; MALIGNANT MESOTHELIOMA; MESOTHELIUM CELL; MITOSIS; MOLECULAR GENETICS; NONHUMAN; SIMIAN VIRUS 40; TUMOR BIOPSY; TUMOR SUPPRESSOR GENE; VIRUS CARCINOGENESIS;

EID: 0035106011     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.2000.0344     Document Type: Article

References (65)

1. The pathogenesis of asbestos-associated diseases
2. Simian virus 40, polio-vaccines and human tumors: A review of recent developments
3. Analysis of current trends in United States mesothelioma incidence
4. Continuing increase in mesothelioma mortality in Britain
5. Mesothelioma
6. Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders
7. Molecular biology of mesothelioma
8. Gene therapy models. The Rb2/p130 gene: The latest weapon in the war against lung cancer?
9. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
10. Structural evidence for the authenticity of the human retinoblastoma gene
11. Promoter deletion and loss of retinoblastoma gene in human prostate carcinoma
12. Point mutational inactivation of the retinoblastoma antioncogene
13. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells
14. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle
15. Retinoblastoma protein and cell cycle
16. The RB family of cell cycle regulatory factors
17. The E2F transcription factor: Role in cell cycle regulation and differentiation
18. A link between the Rb tumor suppressor protein and viral oncoprotein
19. Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain
20. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein
21. Functional analysis of pRB2/p130 interaction with cyclins
22. pRb2/p130 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107
23. Mesothelial cell proliferation and biopersistence of wollastonite and crocidolite asbestos fibers
24. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
25. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
26. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family
27. Structure and function of simian virus 40 large tumor antigen
28. Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107
29. The SV40 large T antigen and adenovirus E1A oncoproteins interact with different isoforms of the transcriptional coactivator, p300
30. p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen
31. Cell and molecular biology of simian virus 40: Implications for human infections and disease
32. Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells
33. Tumorigenicity of human mesothelial cell line transfected with EJ-ras oncogene
34. Oncogenicity of simian virus 40 deletion mutants that induce altered 17-kilodalton t-proteins
35. Enhanced metastasis of tumors induced by a SV40 small deletion mutant
36. SV40 induces mesothelioma in hamsters
37. SV40 small t antigen enhances the transforming activity of limiting concentrations of SV40 large T antigen
38. Immortalization of Balb/c mice embryo fibroblast alters SV40 large T antigen interactions with the tumor suppressor p53 and results in a reduced SV40 transformation efficiency
39. Simian virus 40 small t antigen with cooperates with mitogen activated kinases to stimulate AP-1 activity
40. Simian virus 40-like DNA sequences in human pleural mesothelioma
41. A multi-institutional study confirms the presence and expression of simian virus 40 in human malignant mesotheliomas
42. Presence of simian virus 40 sequences in malignant pleural, peritoneal and noninvasive mesotheliomas
43. Simian virus 40 and pleural mesothelioma in humans
44. SV404-like DNA sequences not detectable in Finnish mesothelioma patients not exposed to SV40 contaminated poliovaccines
45. SV40 DNA in human osteosarcomas shows sequence variation among T-antigen genes
46. New molecular and epidemiological issues in mesothelioma: Role of SV40
47. The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas
48. Simian virus 40-like DNA sequences and large-T antigen-retinoblastoma family protein pRb2/p130 interaction in human mesothelioma
49. Simian virus-40 large-T antigen binds p53 in human mesotheliomas
50. Effect of simian virus large T antigen expression on cell cycle control and apoptosis in rat plural mesothelial cells exposed to DNA damaging agents
51. Rb protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma and mesothelioma
52. p53 and Kirstein-ras mutations in human mesothelioma cell lines
53. Absence of p53 mutation in malignant mesothelioma
54. Recurrent deletions of specific chromosomal sites in 1p, 3p, 6q, and 9p in human malignant mesothelioma
55. Homozygous deletions within 9p21-p22 identify a small critical region of chromosomal loss in human malignant mesothelioma
56. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
57. p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma
58. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
59. Immunohistochemical analysis of the p16INK4 cyclin-dependent kinase inhibitor in malignant mesothelioma
60. Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression
61. Antisense to SV40 early gene region induces growth arrest and apoptosis in T-antigen-positive human pleural mesothelioma cells
62. p19ARF line the tumour suppressor p53 to Ras
63. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
64. Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells
65. Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma