Analysis of genetic alterations associated with DNA diploidy, aneuploidy and multiploidy in gastric cancers

Oncology

Volumn 68, Issue 4-6, 2005, Pages 548-557

  Sugai, Tamotsu ^a   Habano, Wataru ^a   Jiao, Yu Fei ^a   Suzuki, Masamichi ^a   Takagane, Akinori ^a   Nakamura, Shin Ichi ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Cell sorting; Crypt isolation; DNA multiploid; Gastric cancer; Loss of heterozygosity; Microsatellite instability

Indexed keywords

ADULT; AGED; ALLELIC IMBALANCE; ANEUPLOIDY; ARTICLE; CANCER GENETICS; CONTROLLED STUDY; DIPLOIDY; DNA SEQUENCE; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; ISOLATION PROCEDURE; MALE; MICROSATELLITE MARKER; PLOIDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STOMACH CANCER;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANEUPLOIDY; CHROMOSOMES, HUMAN; DIPLOIDY; DNA, NEOPLASM; FEMALE; GENETIC MARKERS; GENOMIC INSTABILITY; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PLOIDIES; POLYMERASE CHAIN REACTION; POLYPLOIDY; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 23844533248     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086999     Document Type: Article

References (37)

1. Tamura G: Molecular pathogenesis of adenoma and differentiated adenocarcinoma of the stomach. Pathol Int 1996;46:834-841.
2. Tahara E: Molecular mechanism of stomach carcinogenesis. J Cancer Res Clin Oncol 1993;119:265-272.
3. Nishizuka S, Tamura G, Terashima M, Satodate R: Loss of heterozygosity during the development and progression of differentiated adenocarcinoma of the stomach. J Pathol 1998;185:38-43.
4. Endoh Y, Tamura G, Ajioka Y, Watanabe H, Motoyama T: Frequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype. Am J Pathol 2000;157:717-722.
5. Endoh Y, Sakata K, Tamura G, Ohmura K, Ajioka Y, Watanabe H, Motoyama T: Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways. J Pathol 2000;191:257-263.
6. Sugai T, Habano W, Uesugi N, Jiao YF, Nakamura S, Sato K, Chiba T, Ishii M: Molecular validation of the modified Vienna classification of colorectal tumors. J Mol Diagn 2002;4:191-200.
7. Habano W, Sugai T, Nakamura S, Uesugi N, Yoshida T, Sasou S: Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma. Gastroenterology 2000;118:835-841.
8. Sugai T, Habano W, Nakamura S, Sato H, Uesugi N, Orii S, Itoh C, Katoh R: Allelic losses of 17p, 5q and 18q loci in diploid and aneuploid populations of multiploid colorectal carcinomas. Hum Pathol 2000;31:925-930.
9. Sugai T, Habano W, Nakamura S, Sato H, Uesugi N, Takahashi H, Jiao Y-F, Yoshida T, Itoh C: Genetic alterations in DNA diploid, aneuploid and multiploid colorectal carcinomas identified by the crypt isolation technique. Int J Cancer 2000;88:614-619.
10. Sugai T, Habano W, Uesugi N, Jiao Y-F, Nakamura S, Yoshida T, Higuchi T: Frequent allelic imbalance at the ATM locus in DNA multiploid colorectal carcinomas. Oncogene 2001;20:6095-6101.
11. Sugai T, Habano W, Nakamura S, Jiao Y-F, Higuchi T, Inomata M, Chiba T: Analysis of Ki-ras gene mutations associated with DNA diploid, aneuploid and multiploid colorectal carcinomas using a crypt isolation technique. Cytometry 2001;46:345-350.
12. Yustein AS, Harper JC, Petroni GR, Cummings OW, Moskaluk CA, Powell SM: Allelo-type of gastric adenocarcinoma. Cancer Res 1999;59:1437-1441.
13. Japanese Research Society for Gastric Cancer: The General Rules for the Gastric Cancer study, ed 12. Tokyo, Kanehara Shuppan, 1993, pp 64-89.
14. Lauren P: The two histological main types of gastric carcinomas: Diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Immunol Scand 1965;64:31-49.
15. Jiao Y-F, Sugai T, Suzuki M, Uesugi N, Habano W, Nakamura S, Takagane A, Suto T, Yoshida T: Application of the crypt isolation technique to the flow cytometric analysis of DNA content in gastric carcinoma. Hum Pathol 2004;35:587-593.
16. Sugai T, Habano W, Nakamura S, Uesugi N, Sasou S, Itoh C: A unique method for mutation analysis of tumor suppressor genes in colorectal carcinomas using a crypt isolation technique. Arch Pathol Lab Med 2000;124:382-386.
17. Sugai T, Habano W, Nakamura S, Uesugi N, Sasou S, Itoh C: Use of crypt isolation to determine loss of heterozygosity of multiple tumor suppressor genes in colorectal carcinoma. Pathol Res Pract 2000;196:145-150.
18. Habano W, Sugai T, Nakamura S, Yoshida T: A novel method for gene analysis of colorectal carcinomas using a crypt isolation technique. Lab Invest 1996;74:933-940.
19. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN, Srivastava S: A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998;58:5248-5257.
20. Lewin KJ, Appelman HD: Tumors of the esophagus and stomach: Carcinoma of the stomach. Washington, AFIP, 1995, pp 267-276.
21. Sugai T, Nakamura S, Uesugi N, Habano W, Yoshida T, Tazawa H, Orii S, Suto T, Itoh C: Role of DNA aneuploidy, overexpression of p53 gene product and cellular proliferation in the progression of gastric cancer. Cytometry 1999;38:111-117.
22. Wright PA, Qurike P, Attanoos R, Williams GT: Molecular pathology of gastric carcinoma: Progress and prospects. Hum Pathol 1992;23:848-859.
23. Kim KM, Kwon MS, Hong SJ, Min KO, Seo EJ, Lee KY, Choi SW, Rhyu MG: Genetic classification of intestinal-type and diffuse-type gastric cancers based on chromosomal loss and microsatellite instability. Virchows Arch 2003;443:491-500.
24. Cho JH, Noguchi M, Ochiai A, Hirohashi S: Loss of heterozygosity of multiple tumor suppressor genes in human gastric cancers by polymerase chain reaction. Lab Invest 1996;74:835-841.
25. Sugai T, Habano W, Nakamura S, Yoshida T, Uesugi N, Suto T, Itoh C: Correlation of histological morphology and tumor stage with molecular genetic analysis using microdissection in gastric carcinomas. Diagn Mol Pathol 1998;7:235-240.
26. Shiao YH, Palli D, Buzard GS, Caporaso NE, Amorosi A, Saieva C, Fraumeni JF Jr, Anderson LM, Rice JM: Implications of p53 mutation spectrum for cancer etiology in gastric cancers of various histologic types from a high-risk area of central Italy. Carcinogenesis 1998;19:2145-2149.
27. Ranzani GN, Luinetti O, Padovan LS, Calistri D, Renault B, Burrel M, Amadori D, Fiocca R, Solcia E: p53 gene mutations and protein nuclear accumulation are early events in intestinal type gastric cancer but late events in diffuse type. Cancer Epidemiol Biomarkers Prev 1995;4:223-231.
28. Thibodeau SN, Bren G, Schaid D: Microsatellite instability in cancer of the proximal colon. Science 1993;260:816-819.
29. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP: CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999;96:8681-8686.
30. Oue N, Oshimo Y, Nakayama H, Ito R, Yoshida K, Matsusaki K, Yasui W: DNA methylation of multiple genes in gastric carcinoma: Association with histological type and CpG island methylator phenotype. Cancer Sci 2003;94:901-905.
31. Pinto M, Oliveira C, Cimes L, Carlos Machado J, Ramires M, Nogueira A, Carneiro F, Seruca R: Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas. J Pathol 2003;200:32-38.
32. Carvalho B, Pinto M, Cirnes L, Oliveira C, Machado JC, Suriano G, Hamelin R, Carneiro F, Seruca R: Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas. Eur J Cancer 2003;39:1222-1227.
33. Ogata S, Tamura G, Endoh Y, Sakata K, Ohmura K, Motoyama T: Microsatellite alterations and target gene mutations in the early stages of multiple gastric cancer. J Pathol 2001;194:334-340.
34. Leung WK, Kim JJ, Kim JG, Graham DY, Sepulveda AR: Microsatellite instability in gastric intestinal metaplasia in patients with and without gastric cancer. Am J Pathol 2000;156:537-543.
35. Jass JR, Whitehall VL, Young J, Leggett BA: Emerging concepts in colorectal neoplasia. Gastroenterology 2002;123:862-876.
36. Barnetson R, Jass J, Tse R, Eckstein R, Robinson B, Schnitzler M: Mutations associated with microsatellite unstable colorectal carcinomas exhibit widespread intratumoral heterogeneity. Genes Chromosomes Cancer 2000;29:130-136.
37. Jiao Y-F, Sugai T, Habano W, Suzuki M, Takagane A, Nakamura S: Analysis of microsatellite alterations in gastric carcinoma using the crypt isolation technique. J Pathol 2004;204/2:200-207.