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Volumn 95, Issue 1, 2005, Pages 173-188

Cartilage-derived morphogenetic proteins induce osteogenic gene expression in the C2C12 mesenchymal cell line

Author keywords

Bone morphogenetic proteins, BMPs; C2C12; Cartilage derived morphogenetic proteins, CDMPs; Gene expression; Growth differentiation factors, GDFs; Osteogenesis; Transforming growth factor , TGF

Indexed keywords

AGGRECAN; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 12; BONE MORPHOGENETIC PROTEIN RECEPTOR IA; BONE MORPHOGENETIC PROTEIN RECEPTOR IIB; CARTILAGE DERIVED MORPHOGENETIC PROTEIN 2; CELL MARKER; CELL PROTEIN; COLLAGEN TYPE 1; GROWTH DIFFERENTIATION FACTOR 5; MESSENGER RNA; MYOD PROTEIN; OSTEOCALCIN; PROTEIN ACTR IA; PROTEIN ALK 7; SCLERAXIS; TENDIN; TRANSCRIPTION FACTOR SIX1; UNCLASSIFIED DRUG;

EID: 23844522605     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20402     Document Type: Article
Times cited : (15)

References (47)
  • 1
    • 0033060271 scopus 로고    scopus 로고
    • Enhanced tendon healing with GDF 5 and 6
    • Aspenberg P, Forslund C. 1999. Enhanced tendon healing with GDF 5 and 6. Acta Orthop Scand 70:51-54.
    • (1999) Acta Orthop Scand , vol.70 , pp. 51-54
    • Aspenberg, P.1    Forslund, C.2
  • 2
    • 0034573631 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and tendon repair
    • Aspenberg P, Forslund C. 2000. Bone morphogenetic proteins and tendon repair [In Process Citation]. Scand J Med Sci Sports 10:372-375.
    • (2000) Scand J Med Sci Sports , vol.10 , pp. 372-375
    • Aspenberg, P.1    Forslund, C.2
  • 3
    • 0034878782 scopus 로고    scopus 로고
    • Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype
    • Banerjee C, Javed A, Choi JY, Green J, Rosen V, van Wijnen AJ, Stein JL, Lian JB, Stein GS. 2001. Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype. Endocrinology 142:4026-4039.
    • (2001) Endocrinology , vol.142 , pp. 4026-4039
    • Banerjee, C.1    Javed, A.2    Choi, J.Y.3    Green, J.4    Rosen, V.5    Van Wijnen, A.J.6    Stein, J.L.7    Lian, J.B.8    Stein, G.S.9
  • 4
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.1
  • 5
    • 0028126646 scopus 로고
    • Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development
    • Chang SC, Hoang B, Thomas JT, Vukicevic S, Luyten FP, Ryba NJ, Kozak CA, Reddi AH, Moos M, Jr. 1994. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. J Biol Chem 269:28227-28234.
    • (1994) J Biol Chem , vol.269 , pp. 28227-28234
    • Chang, S.C.1    Hoang, B.2    Thomas, J.T.3    Vukicevic, S.4    Luyten, F.P.5    Ryba, N.J.6    Kozak, C.A.7    Reddi, A.H.8    Moos Jr., M.9
  • 6
    • 0031059353 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts
    • Chen D, Harris MA, Rossini G, Dunstan CR, Dallas SL, Feng JQ, Mundy GR, Harris SE. 1997. Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts. Calcif Tissue Int 60:283-290.
    • (1997) Calcif Tissue Int , vol.60 , pp. 283-290
    • Chen, D.1    Harris, M.A.2    Rossini, G.3    Dunstan, C.R.4    Dallas, S.L.5    Feng, J.Q.6    Mundy, G.R.7    Harris, S.E.8
  • 10
    • 0032925596 scopus 로고    scopus 로고
    • BMP/GDF-signalling interactions during synovial joint development
    • Francis-West PH, Parish J, Lee K, Archer CW. 1999. BMP/GDF-signalling interactions during synovial joint development. Cell Tissue Res 296:111-119.
    • (1999) Cell Tissue Res , vol.296 , pp. 111-119
    • Francis-West, P.H.1    Parish, J.2    Lee, K.3    Archer, C.W.4
  • 11
    • 0033673311 scopus 로고    scopus 로고
    • Stimulatory effects of cartilage-derived morphogenetic proteins 1 and 2 on osteogenic differentiation of bone marrow stromal cells
    • Gruber R, Mayer C, Schulz W, Graninger W, Peterlik M, Watzek G, Luyten FP, Erlacher L. 2000. Stimulatory effects of cartilage-derived morphogenetic proteins 1 and 2 on osteogenic differentiation of bone marrow stromal cells [In Process Citation]. Cytokine 12:1630-1638.
    • (2000) Cytokine , vol.12 , pp. 1630-1638
    • Gruber, R.1    Mayer, C.2    Schulz, W.3    Graninger, W.4    Peterlik, M.5    Watzek, G.6    Luyten, F.P.7    Erlacher, L.8
  • 12
    • 0035046256 scopus 로고    scopus 로고
    • Effects of cartilage-derived morphogenetic proteins and osteogenic protein-1 on osteochondrogenic differentiation of periosteum-derived cells
    • Gruber R, Mayer C, Bobacz K, Krauth MT, Graninger W, Luyten FP, Erlacher L. 2001. Effects of cartilage-derived morphogenetic proteins and osteogenic protein-1 on osteochondrogenic differentiation of periosteum-derived cells. Endocrinology 142:2087-2094.
    • (2001) Endocrinology , vol.142 , pp. 2087-2094
    • Gruber, R.1    Mayer, C.2    Bobacz, K.3    Krauth, M.T.4    Graninger, W.5    Luyten, F.P.6    Erlacher, L.7
  • 13
    • 0033842229 scopus 로고    scopus 로고
    • Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice
    • Hamrick MW, McPherron AC, Lovejoy CO, Hudson J. 2000. Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice. Bone 27:343-349.
    • (2000) Bone , vol.27 , pp. 343-349
    • Hamrick, M.W.1    McPherron, A.C.2    Lovejoy, C.O.3    Hudson, J.4
  • 14
    • 0031043249 scopus 로고    scopus 로고
    • Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells
    • Honda Y, Knutsen R, Strong DD, Sampath TK, Baylink DJ, Mohan S. 1997. Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells. Calcif Tissue Int 60:297-301.
    • (1997) Calcif Tissue Int , vol.60 , pp. 297-301
    • Honda, Y.1    Knutsen, R.2    Strong, D.D.3    Sampath, T.K.4    Baylink, D.J.5    Mohan, S.6
  • 16
    • 0030585355 scopus 로고    scopus 로고
    • Bone morphogenetic protein-12 and -13 inhibit terminal differentiation of myoblasts, but do not induce their differentiation into osteoblasts
    • Inada M, Katagiri T, Akiyama S, Namika M, Komaki M, Yamaguchi A, Kamoi K, Rosen V, Suda T. 1996. Bone morphogenetic protein-12 and -13 inhibit terminal differentiation of myoblasts, but do not induce their differentiation into osteoblasts. Biochem Biophys Res Commun 222:317-322.
    • (1996) Biochem Biophys Res Commun , vol.222 , pp. 317-322
    • Inada, M.1    Katagiri, T.2    Akiyama, S.3    Namika, M.4    Komaki, M.5    Yamaguchi, A.6    Kamoi, K.7    Rosen, V.8    Suda, T.9
  • 18
    • 0028180315 scopus 로고
    • The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms
    • Kingsley DM. 1994. The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8:133-146.
    • (1994) Genes Dev , vol.8 , pp. 133-146
    • Kingsley, D.M.1
  • 19
    • 0033120916 scopus 로고    scopus 로고
    • Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation
    • Lee MH, Javed A, Kim HJ, Shin HI, Gutierrez S, Choi JY, Rosen V, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Ryoo HM. 1999. Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. J Cell Biochem 73:114-125.
    • (1999) J Cell Biochem , vol.73 , pp. 114-125
    • Lee, M.H.1    Javed, A.2    Kim, H.J.3    Shin, H.I.4    Gutierrez, S.5    Choi, J.Y.6    Rosen, V.7    Stein, J.L.8    Van Wijnen, A.J.9    Stein, G.S.10    Lian, J.B.11    Ryoo, H.M.12
  • 20
    • 0034460993 scopus 로고    scopus 로고
    • Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
    • Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, Wozney JM, Kim EG, Choi JY, Ryoo HM, Bae SC. 2000. Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20:8783-8792.
    • (2000) Mol Cell Biol , vol.20 , pp. 8783-8792
    • Lee, K.S.1    Kim, H.J.2    Li, Q.L.3    Chi, X.Z.4    Ueta, C.5    Komori, T.6    Wozney, J.M.7    Kim, E.G.8    Choi, J.Y.9    Ryoo, H.M.10    Bae, S.C.11
  • 21
    • 0030691086 scopus 로고    scopus 로고
    • Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells
    • Liu Y, Watanabe H, Nifuji A, Yamada Y, Olson EN, Noda M. 1997. Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells. J Biol Chem 272:29880-29885.
    • (1997) J Biol Chem , vol.272 , pp. 29880-29885
    • Liu, Y.1    Watanabe, H.2    Nifuji, A.3    Yamada, Y.4    Olson, E.N.5    Noda, M.6
  • 22
    • 0035217756 scopus 로고    scopus 로고
    • BMP-12 gene transfer augmentation of lacerated tendon repair
    • Lou J, Tu Y, Burns M, Silva MJ, Manske P. 2001. BMP-12 gene transfer augmentation of lacerated tendon repair. J Orthop Res 19:1199-1202.
    • (2001) J Orthop Res , vol.19 , pp. 1199-1202
    • Lou, J.1    Tu, Y.2    Burns, M.3    Silva, M.J.4    Manske, P.5
  • 24
    • 0035019046 scopus 로고    scopus 로고
    • GDF-5 deficiency in mice alters the ultrastructure, mechanical properties and composition of the Achilles tendon
    • Mikic B, Schalet BJ, Clark RT, Gaschen V, Hunziker EB. 2001. GDF-5 deficiency in mice alters the ultrastructure, mechanical properties and composition of the Achilles tendon. J Orthop Res 19:365-371.
    • (2001) J Orthop Res , vol.19 , pp. 365-371
    • Mikic, B.1    Schalet, B.J.2    Clark, R.T.3    Gaschen, V.4    Hunziker, E.B.5
  • 25
    • 0036251987 scopus 로고    scopus 로고
    • The effect of growth/differentiation factor-5 deficiency on femoral composition and mechanical behavior in mice
    • Mikic B, Battaglia TC, Taylor EA, Clark RT. 2002. The effect of growth/differentiation factor-5 deficiency on femoral composition and mechanical behavior in mice. Bone 30:733-737.
    • (2002) Bone , vol.30 , pp. 733-737
    • Mikic, B.1    Battaglia, T.C.2    Taylor, E.A.3    Clark, R.T.4
  • 26
    • 0030826702 scopus 로고    scopus 로고
    • A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts
    • Namiki M, Akiyama S, Katagiri T, Suzuki A, Ueno N, Yamaji N, Rosen V, Wozney JM, Suda T. 1997. A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts. J Biol Chem 272:22046-22052.
    • (1997) J Biol Chem , vol.272 , pp. 22046-22052
    • Namiki, M.1    Akiyama, S.2    Katagiri, T.3    Suzuki, A.4    Ueno, N.5    Yamaji, N.6    Rosen, V.7    Wozney, J.M.8    Suda, T.9
  • 28
    • 0033533606 scopus 로고    scopus 로고
    • Expression of bone morphogenetic protein-2 via adenoviral vector in C2C12 myoblasts induces differentiation into the osteoblast lineage
    • Okubo Y, Bessho K, Fujimura K, Iizuka T, Miyatake S. 1999. Expression of bone morphogenetic protein-2 via adenoviral vector in C2C12 myoblasts induces differentiation into the osteoblast lineage. Biochem Biophys Res Commun 262:739-743.
    • (1999) Biochem Biophys Res Commun , vol.262 , pp. 739-743
    • Okubo, Y.1    Bessho, K.2    Fujimura, K.3    Iizuka, T.4    Miyatake, S.5
  • 30
    • 0035214915 scopus 로고    scopus 로고
    • A growth and differentiation factor-5 (GDF-5)-coated suture stimulates tendon healing in an Achilles tendon model in rats
    • Rickert M, Jung M, Adiyaman M, Richter W, Simank HG. 2001. A growth and differentiation factor-5 (GDF-5)-coated suture stimulates tendon healing in an Achilles tendon model in rats. Growth Factors 19:115-126.
    • (2001) Growth Factors , vol.19 , pp. 115-126
    • Rickert, M.1    Jung, M.2    Adiyaman, M.3    Richter, W.4    Simank, H.G.5
  • 33
    • 0037330644 scopus 로고    scopus 로고
    • Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and GdF5 genes
    • Settle SH, Jr., Rountree RB, Sinha A, Thacker A, Higgins K, Kingsley DM. 2003. Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and GdF5 genes. Dev Biol 254:116-130.
    • (2003) Dev Biol , vol.254 , pp. 116-130
    • Settle Jr., S.H.1    Rountree, R.B.2    Sinha, A.3    Thacker, A.4    Higgins, K.5    Kingsley, D.M.6
  • 34
    • 0344011669 scopus 로고    scopus 로고
    • BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis
    • Shea CM, Edgar CM, Einhorn TA, Gerstenfeld LC. 2003. BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis. J Cell Biochem 90:1112-1127.
    • (2003) J Cell Biochem , vol.90 , pp. 1112-1127
    • Shea, C.M.1    Edgar, C.M.2    Einhorn, T.A.3    Gerstenfeld, L.C.4
  • 36
    • 0033136001 scopus 로고    scopus 로고
    • GDF5 coordinates bone and joint formation during digit development
    • Storm EE, Kingsley DM. 1999. GDF5 coordinates bone and joint formation during digit development. Dev Biol 209:11-27.
    • (1999) Dev Biol , vol.209 , pp. 11-27
    • Storm, E.E.1    Kingsley, D.M.2
  • 39
    • 0242443188 scopus 로고    scopus 로고
    • Effects of osteogenic protein-1 (OP-1, BMP-7) on gene expression in cultured medial collateral ligament cells
    • Tsai AD, Yeh LC, Lee JC. 2003. Effects of osteogenic protein-1 (OP-1, BMP-7) on gene expression in cultured medial collateral ligament cells. J Cell Biochem 90:777-791.
    • (2003) J Cell Biochem , vol.90 , pp. 777-791
    • Tsai, A.D.1    Yeh, L.C.2    Lee, J.C.3
  • 40
    • 0031594665 scopus 로고    scopus 로고
    • Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells
    • Tsuji K, Ito Y, Noda M. 1998. Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells. Bone 22:87-92.
    • (1998) Bone , vol.22 , pp. 87-92
    • Tsuji, K.1    Ito, Y.2    Noda, M.3
  • 43
    • 0030885311 scopus 로고    scopus 로고
    • Osteogenic protein-1 and insulin-like growth factor I synergistically stimulate rat osteoblastic cell differentiation and proliferation
    • Yeh LC, Adamo ML, Olson MS, Lee JC. 1997. Osteogenic protein-1 and insulin-like growth factor I synergistically stimulate rat osteoblastic cell differentiation and proliferation. Endocrinology 138:4181-4190.
    • (1997) Endocrinology , vol.138 , pp. 4181-4190
    • Yeh, L.C.1    Adamo, M.L.2    Olson, M.S.3    Lee, J.C.4
  • 44
    • 0033847399 scopus 로고    scopus 로고
    • Osteogenic protein-1 differentially regulates the mRNA expression of bone morphogenetic proteins and their receptors in primary cultures of osteoblasts
    • Yeh LC, Unda R, Lee JC. 2000. Osteogenic protein-1 differentially regulates the mRNA expression of bone morphogenetic proteins and their receptors in primary cultures of osteoblasts. J Cell Physiol 185:87-97.
    • (2000) J Cell Physiol , vol.185 , pp. 87-97
    • Yeh, L.C.1    Unda, R.2    Lee, J.C.3
  • 45
    • 0036237950 scopus 로고    scopus 로고
    • Differential effects of osteogenic protein-1 (BMP-7) on gene expression of BMP and GDF family members during differentiation of the mouse MC615 chondrocyte cells
    • Yeh LC, Mallein-Gerin F, Lee JC. 2002a. Differential effects of osteogenic protein-1 (BMP-7) on gene expression of BMP and GDF family members during differentiation of the mouse MC615 chondrocyte cells. J Cell Physiol 191:298-309.
    • (2002) J Cell Physiol , vol.191 , pp. 298-309
    • Yeh, L.C.1    Mallein-Gerin, F.2    Lee, J.C.3
  • 46
    • 0036031931 scopus 로고    scopus 로고
    • Osteogenic protein-1 (OP-1, BMP-7) induces osteoblastic cell differentiation of the pluripotent mesenchymal cell line C2C12
    • Yeh LC, Tsai AD, Lee JC. 2002b. Osteogenic protein-1 (OP-1, BMP-7) induces osteoblastic cell differentiation of the pluripotent mesenchymal cell line C2C12. J Cell Biochem 87:292-304.
    • (2002) J Cell Biochem , vol.87 , pp. 292-304
    • Yeh, L.C.1    Tsai, A.D.2    Lee, J.C.3
  • 47
    • 7544238376 scopus 로고    scopus 로고
    • Cartilage-derived morphogenetic proteins enhance the osteogenic protein-1-induced osteoblastic cell differentiation of C2C12 cells
    • Yeh L-CC, Tsai AD, Zavala MC, Lee JC. 2004. Cartilage-derived morphogenetic proteins enhance the osteogenic protein-1-induced osteoblastic cell differentiation of C2C12 cells. J Cell Physiol 201:401-408.
    • (2004) J Cell Physiol , vol.201 , pp. 401-408
    • Yeh, L.-C.C.1    Tsai, A.D.2    Zavala, M.C.3    Lee, J.C.4


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