Identification of classical swine fever virus protein E2 as a target for cytotoxic T cells by using mRNA-transfected antigen-presenting cells

Journal of General Virology

Volumn 86, Issue 9, 2005, Pages 2525-2534

  Ceppi, M ^a,e   de Bruin, M G M ^b   Seuberlich, T ^a   Balmelli, C ^a   Pascolo, S ^c   Ruggli, N ^a   Wienhold, D ^d   Tratschin, J D ^a   McCullough, K C ^a   Summerfield, Artur ^a  

^a INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (Switzerland)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^e CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GAMMA INTERFERON; MESSENGER RNA; NONSTRUCTURAL PROTEIN 3; PESTIVIRUS VACCINE; PROTEIN NS4; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN E2; VIRUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DENDRITIC CELL; GENE IDENTIFICATION; GENETIC TRANSFECTION; HAPLOTYPE; IN VITRO STUDY; MONOCYTE; NONHUMAN; PESTIVIRUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; RNA TRANSLATION; SWINE DISEASE; T LYMPHOCYTE ACTIVATION; TARGET CELL; VACCINATION; VACCINE PRODUCTION; VIRUS GENE;

ANIMALS; ANTIGEN-PRESENTING CELLS; CELL LINE, TRANSFORMED; CLASSICAL SWINE FEVER; CLASSICAL SWINE FEVER VIRUS; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; EPITOPES, T-LYMPHOCYTE; MONOCYTES; RNA, MESSENGER; SWINE; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; VIRAL ENVELOPE PROTEINS;

CLASSICAL SWINE FEVER VIRUS;

EID: 23844439739     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.80907-0     Document Type: Article

References (44)

1. Alvarez, B., Sánchez, C., Bullido, R., Marina, A., Lunney, J., Alonso, F., Ezquerra, A. & Domínguez, J. (2000). A porcine cell surface receptor identified by monoclonal antibodies to SWC3 is a member of the signal regulatory protein family and associates with protein-tyrosine phosphatase SHP-1. Tissue Antigens 55, 342-351.
2. Armengol, E., Wiesmüller, K.-H., Wienhold, D., Büttner, M., Pfaff, E., Jung, G. & Saalmüller, A. (2002). Identification of T-cell epitopes in the structural and non-structural proteins of classical swine fever virus. J Gen Virol 83, 551-560.
3. Balmelli, C., Ruggli, N., McCullough, K. & Summerfield, A. (2005). Fibrocytes are potent stimulators of anti-virus cytotoxic T cells. J Leukoc Biol 77, 923-933.
4. Bungener, L., Huckriede, A., Wilschut, J. & Daemen, T. (2002). Delivery of protein antigens to the immune system by fusion-active virosomes: a comparison with liposomes and ISCOMs. Biosci Rep 22, 323-338.
5. Carralot, J.-P., Probst, J., Hoerr, I., Scheel, B., Teufel, R., Jung, G., Rammensee, H.-G. & Pascolo, S. (2004). Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines. Cell Mol Life Sci 61, 2418-2424.
6. Carrasco, C. P., Rigden, R. C., Schaffner, R. & 7 other authors (2001). Porcine dendritic cells generated in vitro: morphological, phenotypic and functional properties. Immunology 104, 175-184.
7. Ceppi, M., Ruggli, N., Tache, V., Gerber, H., McCullough, K. C. & Summerfield, A. (2005). Double-stranded secondary structures on mRNA induce type I interferon (IFN α/β) production and maturation of mRNA-transfected monocyte-derived dendritic cells. J Gene Med 7, 452-465.
8. Chikh, G. & Schutze-Redelmeier, M.-P. (2002). Liposomal delivery of CTL epitopes to dendritic cells. Biosci Rep 22, 339-353.
9. Dahle, J. & Liess, B. (1995). Assessment of safety and protective value of a cell culture modified strain "C" vaccine of hog cholera/classical swine fever virus. Berl Munch Tierarztl Wochenschr 108, 20-25.
10. de Bruin, T. G. M., van Rooij, E. M. A., de Visser, Y. E., Voermans, J. J. M., Samsom, J. N., Kimman, T. G. & Bianchi, A. T. J. (2000). Discrimination of different subsets of cytolytic cells in pseudorabies virus-immune and naive pigs. J Gen Virol 81, 1529-1537.
11. Dewulf, J., Laevens, H., Koenen, F., Mintiens, K. & de Kruif, A. (2004). Efficacy of E2-sub-unit marker and C-strain vaccines in reducing horizontal transmission of classical swine fever virus in weaner pigs. Prev Vet Med 65, 121-133.
12. Greiser-Wilke, I., Moennig, V., Coulibaly, C. O. Z., Dahle, J., Leder, L. & Liess, B. (1990). Identification of conserved epitopes on a hog cholera virus protein. Arch Virol 111, 213-225.
13. Greiser-Wilke, I., Dittmar, K. E., Liess, B. & Moennig, V. (1992). Heterogeneous expression of the non-structural protein p80/p125 in cells infected with different pestiviruses. J Gen Virol 73, 47-52.
14. Hoerr, I., Obst, R., Rammensee, H.-G. & Jung, G. (2000). In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies. Eur J Immunol 30, 1-7.
15. Knoetig, S. M., Summerfield, A., Spagnuolo-Weaver, M. & McCullough, K. C. (1999). Immunopathogenesis of classical swine fever: role of monocytic cells. Immunology 97, 359-366.
16. Koziel, M. J., Dudley, D., Afdhal, N., Choo, Q.-L., Houghton, M., Ralston, R. & Walker, B. D. (1993). Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol 67, 7522-7532.
17. Maurer, R., Stettler, P., Ruggli, N., Hofmann, M. A. & Tratschin, J. D. (2005). Oronasal vaccination with classical swine fever virus (CSFV) replicon particles with either partial or complete deletion of the E2 gene induces partial protection against lethal challenge with highly virulent CSFV. Vaccine 23, 3318-3328.
18. McCullough, K. C., Schaffner, R., Fraefel, W. & Kihm, U. (1993). The relative density of CD44-positive porcine monocytic cell populations varies between isolations and upon culture and influences susceptibility to infection by African swine fever virus. Immunol Lett 37, 83-90.
19. Meyers, G. & Thiel, H.-J. (1996). Molecular characterization of pestiviruses. Adv Virus Res 47, 53-118.
20. Meyers, G., Rümenapf, T. & Thiel, H.-J. (1989). Molecular cloning and nucleotide sequence of the genome of hog cholera virus. Virology 171, 555-567.
21. Morón, G., Dadaglio, G. & Leclerc, C. (2004). New tools for antigen delivery to the MHC class I pathway. Trends Immunol 25, 92-97.
22. Pauly, T., Elbers, K., König, M., Lengsfeld, T., Saalmüller, A. & Thiel, H.-J. (1995). Classical swine fever virus-specific cytotoxic T lymphocytes and identification of a T cell epitope. J Gen Virol 76, 3039-3049.
23. Peeters, B., de Wind, N., Broer, R., Gielkens, A. & Moormann, R. (1992). Glycoprotein H of pseudorabies virus is essential for entry and cell-to-cell spread of the virus. J Virol 66, 3888-3892.
24. Ponsaerts, P., Van Tendeloo, V. F. I. & Berneman, Z. N. (2003). Cancer immunotherapy using RNA-loaded dendritic cells. Clin Exp Immunol 134, 378-384.
25. + T cells and antiviral immunity. Immunity 20, 47-58.
26. Roehrig, J. T. (2003). Antigenic structure of flavivirus proteins. Adv Virus Res 59, 141-175.
27. Ruggli, N., Tratschin, J. D., Mittelholzer, C. & Hofmann, M. A. (1996). Nucleotide sequence of classical swine fever virus strain Alfort/187 and transcription of infectious RNA from stably cloned full-length cDNA. J Virol 70, 3478-3487.
28. Sarobe, P., Huarte, E., Lasarte, J. J., López-Díaz de Cerio, A., García, N., Borrás-Cuesta, F. & Prieto, J. (2001). Characterization of an immunologically conserved epitope from hepatitis C virus E2 glycoprotein recognized by HLA-A2 restricted cytotoxic T lymphocytes. J Hepatol 34, 321-329.
29. Schubert, U., Antón, L. C., Gibbs, J., Norbury, C. C., Yewdell, J. W. & Bennink, J. R. (2000). Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature 404, 770-774.
30. Strobel, I., Berchtold, S., Götze, A., Schulze, U., Schuler, G. & Steinkasserer, A. (2000). Human dendritic cells transfected with either RNA or DNA encoding influenza matrix protein M1 differ in their ability to stimulate cytotoxic T lymphocytes. Gene Ther 7, 2028-2035.
31. Suradhat, S., Intrakamhaeng, M. & Damrongwatanapokin, S. (2001). The correlation of virus-specific interferon-gamma production and protection against classical swine fever virus infection. Vet Immunol Immunopathol 83, 177-189.
32. Terpstra, C. & Wensvoort, G. (1988). The protective value of vaccine-induced neutralising antibody titres in swine fever. Vet Microbiol 16, 123-128.
33. Terpstra, C., Woortmeyer, R. & Barteling, S. J. (1990). Development and properties of a cell culture produced vaccine for hog cholera based on the Chinese strain. Dtsch Tierarztl Wochenschr 97, 77-79.
34. Thornburg, C., Boczkowski, D., Gilboa, E. & Nair, S. K. (2000). Induction of cytotoxic T lymphocytes with dendritic cells transfected with human papillomavirus E6 and E7 RNA: implications for cervical cancer immunotherapy. J Immunother 23, 412-418.
35. Tuyaerts, S., Michiels, A., Corthals, J., Bonehill, A., Heirman, C., De Greef, C., Noppe, S. M. & Thielemans, K. (2003). Induction of influenza matrix protein 1 and MelanA-specific T lymphocytes in vitro using mRNA-electroporated dendritic cells. Cancer Gene Ther 10, 696-706.
36. + hematopoietic progenitors can be transfected with mRNA and induce antigen-specific cytotoxic T cell responses. J Immunol Methods 285, 171-180.
37. rns or E2 of CSFV. Vaccine 20, 1544-1556.
38. van Oirschot, J. T. (2003). Vaccinology of classical swine fever: from lab to field. Vet Microbiol 96, 367-384.
39. Van Tendeloo, V. F. I., Ponsaerts, P., Lardon, F., Nijs, G., Lenjou, M., Van Broekhoven, C., Van Bockstaele, D. R. & Berneman, Z. N. (2001). Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells. Blood 98, 49-56.
40. Weissman, D., Ni, H., Scales, D. & 7 other authors (2000). HIV gag mRNA transfection of dendritic cells (DC) delivers encoded antigen to MHC class I and II molecules, causes DC maturation, and induces a potent human in vitro primary immune response. J Immunol 165, 4710-4717.
41. Wensvoort, G., Terpstra, C., De Kluijver, E. P., Kragten, C. & Warnaar, J. C. (1989). Antigenic differentiation of pestivirus strains with monoclonal antibodies against hog cholera virus. Vet Microbiol 21, 9-20.
42. rns deletion mutants: trans-complementation and potential use as nontransmissible, modified, live-attenuated marker vaccines. J Virol 74, 2973-2980.
43. Yewdell, J. W., Schubert, U. & Bennink, J. R. (2001). At the crossroads of cell biology and immunology: DRiPs and other sources of peptide ligands for MHC class I molecules. J Cell Sci 114, 845-851.
44. Zarei, S., Arrighi, J.-F., Ongaro, G., Calzascia, T., Haller, O., Frossard, C., Piguet, V., Walker, P. R. & Hauser, C. (2003). Efficient induction of CD8 T-associated immune protection by vaccination with mRNA transfected dendritic cells. J Invest Dermatol 121, 745-750.