Modulation of Ca 2+-dependent and Ca 2+-independent miniature endplate potentials by phorbol ester and adenosine in frog

British Journal of Pharmacology

Volumn 145, Issue 7, 2005, Pages 954-962

  Searl, Timothy J ^a   Silinsky, Eugene M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Ach; Neuromuscular transmission; Neurotransmitter release

Indexed keywords

4 AMINOQUINALDINE; ADENOSINE; BOTULINUM TOXIN; PHORBOL DIBUTYRATE; PHORBOL ESTER; QUINALDINE DERIVATIVE; SNARE PROTEIN; SYNAPTOBREVIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DEPOLARIZATION; DRUG ACTIVITY; DRUG MECHANISM; FROG; MINIATURE ENDPLATE POTENTIAL; NEUROMUSCULAR TRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; SENSOR;

ADENOSINE; AMINOQUINOLINES; ANIMALS; BOTULINUM TOXINS; CALCIUM; MEMBRANE POTENTIALS; MOTOR ENDPLATE; NEUROMUSCULAR JUNCTION; PECTORALIS MUSCLES; PHORBOL 12,13-DIBUTYRATE; POTASSIUM; QUINALDINES; RANA PIPIENS; SUCROSE; SYNAPTIC TRANSMISSION;

EID: 23744465739     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706248     Document Type: Article

References (29)

1. BETZ, A., ASHERY, U., RICKMANN, M., AUGUSTIN, I., NEHER, E., SUDHOF, T.C., RETTIG, J. & BROSE, N. (1998). Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. Neuron, 21, 123-136.
2. BROSE, N. & ROSENMUND, C. (2002). Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. J. Cell Sci., 115, 4399-4411.
3. GERST, J.E. (1999). SNAREs and SNARE regulators in membrane fusion and exocytosis. Cell Mol. Life Sci., 55, 707-734.
4. JAHN, R., HANSON, P.I., OTTO, H. & AHNERT-HILGER, G. (1995). Botulinum and tetanus neurotoxins: emerging tools for the study of membrane fusion. Cold Spring Harbor Symp. Quant. Biol., LX, 329-335.
5. KIDOKORO, Y. (2003). Roles of SNARE proteins and synaptotagmin I in synaptic transmission: studies at the Drosophila neuromuscular synapse. NeuroSignals, 12, 13-30.
6. LUPA, M.T., TABTI, N., THESLEFF, S., VYSKOCIL, F. & YU, S.P. (1986). The nature and origin of calcium-insensitive miniature end-plate potentials at rodent neuromuscular junctions. J. Physiol., 381, 607-618.
7. LUPA, M.T. & YU, S.P. (1986). A comparison of miniature end-plate potentials at normal, denervated, and long-term botulinum toxin type A poisoned frog neuromuscular junctions. Pflugers Archiv., 407, 476-481.
8. MOLGO, J., GOMEZ, S., POLAK, R.L. & THESLEFF, S. (1982). Giant miniature endplate potentials induced by 4-aminoquinoline. Acta Physiol. Scand., 115, 201-207.
9. MONTEITH, D.K. & THEISS, J.C. (1996). Comparison of tacrine-induced cytotoxicity in primary cultures of rat, mouse, monkey, dog, rabbit, and human hepatocytes. Drug Chem. Toxicol., 19, 59-70.
10. MORIMOTO, T., POPOV, S., BUCKLEY, K.M. & POO, M.M. (1995). Calcium-dependent transmitter secretion from fibroblasts: modulation by synaptotagmin I. Neuron, 15, 689-696.
11. PLYMALE, D.R. & DE LA IGLESIA, F.A. (1999). Acridine-induced subcellular and functional changes in isolated human hepatocytes in vitro. J. Appl. Toxicol., 19, 31-38.
12. RACIBORSKA, D.A., TRIMBLE, W.S. & CHARLTON, M.P. (1998). Presynaptic protein interactions in vivo: evidence from botulinum A, C, D and E action at neuromuscular junctions. Eur. J. Neurosci., 10, 2617-2628.
13. REDMAN, R.S., SEARL, T.J., HIRSH, J.K. & SILINSKY, E.M. (1997). Opposing effects of phorbol esters on transmitter release and calcium currents at frog motor nerve endings. J. Physiol., 501, 41-48.
14. RIZZOLI, S.O. & BETZ, W.J. (2002). Effects of 2-(4-morpholinyl)-8- phenyl-4H-1-benzopyran-4-one on synaptic vesicle cycling at the frog neuromuscular junction. J. Neurosci., 22, 10680-10689.
15. 2+ entry in the nerve terminal of the frog neuromuscular junction. Can. J. Physiol. Pharmacol., 77, 707-714.
16. SEARL, T.J. & SILINSKY, E.M. (1998). Increases in acetylcholine release produced by phorbol esters are not mediated by protein kinase C at motor nerve endings. J. Pharmacol. Exp. Ther., 285, 247-251.
17. SEARL, T.J. & SILINSKY, E.M. (2003). Phorbol esters and adenosine affect the readily releasable neurotransmitter pool by different mechanisms at amphibian motor nerve endings. J. Physiol., 553, 445-456.
18. SELLIN, L.C., MOLGO, J., TORNQUIST, K., HANSSON, B. & THESLEFF, S. (1986). On the possible origin of giant or slow-rising miniature end-plate potentials at the neuromuscular junction. Pflugers Archiv., 431, 325-334.
19. SILINSKY, E.M. (1980). Evidence for specific adenosine receptors at cholinergic nerve endings. Br. J. Pharmacol., 71, 191-194.
20. SILINSKY, E.M. (1981). On the calcium receptor that mediates depolarization-secretion coupling at cholinergic motor nerve terminals. Br. J. Pharmacol., 73, 413-429.
21. SILINSKY, E.M. (1984). On the mechanism by which adenosine receptor activation inhibits the release of acetylcholine from motor nerve endings. J. Physiol., 346, 243-256.
22. SILINSKY, E.M. (1985). The biophysical pharmacology of calcium-dependent acetylcholine secretion. Pharmacol. Rev., 37, 81-132.
23. SILINSKY, E.M. & SEARL, T.J. (2003). Phorbol esters and neurotransmitter release; more than just protein kinase C? Br. J. Pharmacol., 138, 1191-1201.
24. STEVENS, C.F. & SULLIVAN, J.M. (1998). Regulation of the readily-releasable vesicle pool by protein kinase C. Neuron, 21, 885-893.
25. SUTTON, R.B., FASSHAUER, D., JAHN, R. & BRUNGER, A.T. (1998). Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature, 395, 347-353.
26. TABTI, N., LUPA, M.T. & THESLEFF, S. (1986). Effects of some aminoquinolines on spontaneous quantal acetylcholine release. Acta. Physiol. Scand., 127, 553-555.
27. THESLEFF, S. & MOLGO, J. (1983). A new type of transmitter release at the neuromuscular junction. Neuroscience, 9, 1-8.
28. THESLEFF, S., MOLGO, J. & LUNDH, H. (1983). Botulinum toxin and 4-aminoquinoline induce a similar abnormal type of spontaneous quantal transmitter release at the rat neuromuscular junction. Brain Res., 264, 89-97.
29. THESLEFF, S., SELLIN, L.C. & TAGERUD, S. (1990). Tetrahydroaminoacridine (tacrine) stimulates neurosecretion at mammalian motor endplates. Br. J. Pharmacol., 100, 487-490.