Presynaptic protein interactions in vivo: Evidence from botulinum A, C, D and E action at frog neuromuscular junction

European Journal of Neuroscience

Volumn 10, Issue 8, 1998, Pages 2617-2628

  Raciborska, Dorota A ^a   Trimble, William S ^a,b   Charlton, Milton P ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

SNAP 25; SNARE; Syntaxin; VAMP synaptobrevin

Indexed keywords

BOTULINUM TOXIN; BOTULINUM TOXIN A; CALCIUM CHANNEL; SYNAPTOBREVIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FROG; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MUSCLE CONTRACTION; NERVE ENDING; NEUROMUSCULAR SYNAPSE; NEUROTOXICITY; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ANIMALS; BOTULINUM TOXINS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NEUROMUSCULAR JUNCTION; NEUROTRANSMITTER AGENTS; PRESYNAPTIC TERMINALS; PROTEIN BINDING; QA-SNARE PROTEINS; R-SNARE PROTEINS; RANA PIPIENS; SNARE PROTEINS; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; TIME FACTORS; VESICULAR TRANSPORT PROTEINS;

EID: 0031901958     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1998.00270.x     Document Type: Article

References (13)

1. 2+-dependent exocytosis. J. Biol. Chem., 271, 20227-20230.
2. Bean, A.J., Seifert, R., Chen, Y.A., Sacks, R. & Scheller, R.H. (1997) Hrs-2 is an ATPase implicated in calcium-regulated secretion. Nature, 385, 826-829.
3. Bennett, M.K., Calakos, N. & Scheller, R.H. (1992) Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science, 257, 255-259.
4. Binz, T., Blasi, J., Yamasaki, S., Baumeister, A., Link, E., Südhof, T.C., Jahn, R. & Niemann, H. (1994) Proteolysis of SNAP-25 by types E and A botulinal neurotoxins. J. Biol. Chem., 269, 1617-1620.
5. Blasi, J., Chapman, E.R., Link, E., Binz, T., Yamasaki, S., De Camilli, P., Südhof, T.C., Niemann, H. & Jahn, R. (1993a) Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25. Nature, 365, 160-163.
6. Blasi, J., Chapman, E.R., Yamasaki, S., Binz, T., Niemann, H. & Jahn, R. (1993b) Botulinum neurotoxin Cl blocks neurotransmitter release by means of cleaving HPC-1/syntaxin. EMBO J., 12, 4821-4828.
7. Boudier, J.-A., Charvin, N., Boudier, J.-L., Fathallah, M., Tagaya, M., Takahashi, M. & Seagar, M.J. (1996) Distribution of components of the SNARE complex in relation to transmitter release sites at the frog neuromuscular junction. Eur. J. Neurosci., 8, 545-552.
8. Bruns, D., Engers, S., Yang, C., Ossig, R., Jeromin, A. & Jahn, R. (1997) Inhibition of transmitter release correlates with the proteolytic activity of tetanus toxin and botulinus toxin A in individual cultured synapses of Hirudo medicinalis. J. Neurosci., 17, 1898-1910.
9. Ceccarelli, B., Grohovaz, F. & Hurlbut, W.P. (1979) Freeze-fracture studies of frog neuromuscular junctions during intense release of neurotransmitter. II. Effects of electrical stimulation and high potassium. J. Cell Biol., 81, 178-192.
10. Chapman, E.R., An, S., Barton, N. & Jahn, R. (1994) SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils. J. Biol. Chem., 269, 27427-27432.
11. Chapman, E.R., Hanson, P.I. & Jahn, R. (1995) The neuronal exocytotic fusion machine: some new developments. Neuropharmacology, 34, 1343-1349.
12. Coffield, J.A., Bakry, N., Zhang, R.-D., Carlson, J., Gomella, L.G. & Simpson, L.L. (1997) In vitro characterization of botulinum toxin types A, C and D action on human tissues: combined electrophysiologic, pharmacologic and molecular biologic approaches. J. Pharmacol. Exp. Ther., 280, 1489-1498.
13. 2+ channels on frog motor nerve terminals revealed by fluorescent omega-conotoxin. J. Neurosci., 11, 1032-1039.