Increases in acetylcholine release produced by phorbol esters are not mediated by protein kinase C at motor nerve endings

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 1, 1998, Pages 247-251

  Searl, T J ^a   Silinsky, E M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ACETYLCHOLINE; CALPHOSTIN C; PHORBOL DIBUTYRATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SPHINGOSINE; STAUROSPORINE;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDPLATE POTENTIAL; FROG; NERVE ENDING; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL;

ACETYLCHOLINE; ANIMALS; CARCINOGENS; ENZYME INHIBITORS; NAPHTHALENES; NEUROMUSCULAR JUNCTION; PHORBOL ESTERS; PROTEIN KINASE C; RANA PIPIENS; SPHINGOSINE; STAUROSPORINE;

EID: 0031958161     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Ahmed S, Kozma R, Lee J, Monfries C, Harden N and Lim L (1991) The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol binding. Biochem J 280:233-241.
2. Ahmed S, Kozma R, Monfries C, Hall C, Lim HH, Smith P and Lim L (1990) Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor. Biochem J 272: 767-773.
3. Ahmed S, Lee J, Kozma R, Best A, Monfries C and Lim L (1993) A novel functional target for tumour-promoting phorbol esters and lysophosphatidic acid. The p21rac GTPase activating protein n-chimaerin. J Biol Chem 268:10709-10712.
4. Ahmed S, Maruyama IN, Kozma R, Lee J, Brenner S and Lim L (1992) The Caenorhabditis elegans unc-13 gene product is a phospholipid-dependent high affinity phorbol ester receptor. Biochem J 287:995-999.
5. 2-domain proteins. J Biol Chem 270:25273-25280.
6. Bruns RK, Miller FD, Merriman RL, Howbert JJ, Heath WF, Kobayashi E, Takahashi I, Tamaoki T and Hirofumi N (1991) Inhibition of protein kinase C by calphostin C is light dependent. Biochem Biophys Res Commun 176:288-293.
7. Considine RV, Sherwin JS and Simpson LL (1992) Role of protein kinase C in short-term transmission at the mammalian neuromuscular junction. J Pharmacol Exp Ther 263:1269-1274.
8. Del Castillo J and Katz B (1954) Quantal components of the end-plate potential. J Physiol (Lond) 124:560-573.
9. Glantz SA (1992) Primer of Biostatistics, McGraw-Hill, Inc., New York.
10. Gordge PC and Ryves WJ (1994) Inhibitors of protein kinase C. Cell Signal 6:871-882.
11. Hirsh JK, Silinsky EM and Solsona CS (1990) The role of cyclic AMP and its protein kinase in mediating acetylcholine release and the action of adenosine at frog motor nerve endings. Br J Pharmacol 101:311-318.
12. Jaken S (1996) Protein kinase C isozymes and substrates. Curr Opin Cell Biol 8:168-173.
13. Kazanietz MG, Lewin NE, Bruns JD and Blumberg PM (1995) Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand binding interactions, lipid cofactor requirements and inhibitor sensitivity. J Biol Chem 270:10777-10783.
14. Kobayashi E, Nakano H, Morimoto M and Tamaoki T (1989) Calphostin C (UCN-1028C). a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159:548-553.
15. Maruvama IN and Brenner S (1991) A phorbol ester/diacylglycerol-binding protein encoded by the unc13 gene of Caenorhabditis elegans. Proc Natl Acad Sci USA 88:5729-5733.
16. Miwa J, Tabuse Y, Furusawa M and Yamasaki H (1982) Tumour promoters specifically and reversibly disturb development and behaviour of Caenorhabditis elegans. J Cancer Res Clin Oncol 104:81-87.
17. Newton AC (1995) Protein kinase C: Structure function and regulation. J Biol Chem 270:28495-28498.
18. Nishizuka Y (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (Lond) 334:661-665.
19. Rahimimoff R (1967) The use of the Biomac 500 computer for estimating facilitation at single end-plates. J Physiol (Lond) 191:12P-13P.
20. Redman RS, Searl TJ, Hirsh JK and Silinsky EM (1997) Opposing effects of phorbol esters on transmitter release and calcium currents at frog motor nerve endings. J Physiol (Lond) 501.1:41-48.
21. Sebastiao AM and Ribeiro JA (1990) Interactions between adenosine and phorbol esters or lithium at the frog neuromuscular junction. Br J Pharmacol 100:55-62.
22. Shapira R, Silberberg SD, Ginsburg S and Rahamimoff R (1987) Activation of protein kinase C augments evoked transmitter release. Nature (Lond) 325:58-60.
23. Silinsky EM (1981) On the calcium receptor that mediates depolarization-secretion coupling at cholinergic motor nerve terminals. Br J Pharmacol 73:413-429.
24. Silinsky EM (1984) On the mechanism by which adenosine receptor activation inhibits the release of acetylcholine from motor nerve endings. J Physiol (Lond) 346:243-256.
25. 2+ dependent protein kinase. Biochem Biophys Res Commun 135:397-402.
26. Wardell CF and Cunnane TC (1994) Biochemical machinery involved in the release of ATP from sympathetic nerve terminals. Br J Pharmacol 111:975-977.