Models for studying DNA methylation in human cancer: A review of current status

Drug Discovery Today: Disease Models

Volumn 1, Issue 1, 2004, Pages 37-42

  Toyooka, Shinichi ^a   Shimizu, Nobuyoshi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA METHYLTRANSFERASE; SMALL INTERFERING RNA;

ARABIDOPSIS; CANCER; CANCER SURVIVAL; CARCINOGENESIS; COMPUTER MODEL; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; INFECTION SENSITIVITY; LUNG NON SMALL CELL CANCER; LUNG TUMOR; MESOTHELIOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; REVIEW; TUMOR MODEL;

EID: 23744436846     PISSN: 17406757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmod.2004.01.002     Document Type: Review

References (20)

1. Bird, A.P. Wolffe, A.P. (1999) Methylation-induced repression - belts, braces, and chromatin, Cell 99 (5), 451-454
2. Issa, J.P. (2003) Decitabine, Curr. Opin. Oncol. 15 (6), 446-451
3. Zochbauer-Muller, S. et al. (2002) Aberrant DNA methylation in lung cancer: biological and clinical implications, Oncologist 7 (5), 451-457
4. Toyooka, S. et al. (2001) DNA methylation profiles of lung tumors, Mol. Cancer Ther. 1 (1), 61-67
5. Herman, J.G. et al. (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands, Proc. Natl. Acad. Sci. U.S.A. 93 (18), 9821-9826
6. Xiong, Z. Laird, P.W. (1997) COBRA: a sensitive and quantitative DNA methylation assay, Nucleic Acids Res. 25 (12), 2532-2534
7. Laird, P.W. (2003) The power and the promise of DNA methylation markers, Nat. Rev. Cancer 3 (4), 253-266
8. Matsuyama, T. et al. (2003) Global methylation screening in the Arabidopsis thaliana and Mus musculus genome: applications of virtual image restriction landmark genomic scanning (Vi-RLGS), Nucleic Acids Res. 31 (15), 4490-4496
9. Bocchetta, M. et al. (2000) Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity, Proc. Natl. Acad. Sci. U.S.A. 97 (18), 10214-10219
10. Bocchetta, M. et al. (2003) Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells, Oncogene 22 (1), 81-89
11. Toyooka, S. et al. (2002) Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells, Oncogene 21 (27), 4340-4344
12. Yang, Z. et al. (2003) Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma, Am. J. Pathol. 163 (3), 1101-1107
13. Kang, G.H. et al. (2002) positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma, Am. J. Pathol. 160 (3), 787-794
14. Robert, M.E et al. (2003) DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells, Nat. Genet. 33 (1), 61-65.
15. Villar-Garea, A. et al. (2003) Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells, Cancer Res. 63 (16), 4984-4989
16. Belinsky, S.A. et al. (1998) Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis, Proc. Natl. Acad. Sci. U.S.A. 95 (20), 11891-11896
17. Toyooka, S. et al. (2003) Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer, Int. J. Cancer 103 (2), 153-160
18. Lantry, L.E. et al. (1999) 5-Aza-2′-deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced primary mouse lung tumor model, Carcinogenesis 20 (2), 343-346
19. Plumb, J.A. et al. (2000) Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter, Cancer Res. 60 (21), 6039-6044
20. Belinsky, S.A. et al. (1993) The A/J mouse lung as a model for developing new chemointervention strategies, Cancer Res. 53 (2), 410-416