Balancing diversity and tolerance: Lessons from patients with systemic lupus erythematosus

Journal of Experimental Medicine

Volumn 202, Issue 3, 2005, Pages 341-344

  Jacobi, Annett M ^a   Diamond, Betty ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD27 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; DNA ANTIBODY; ESTRADIOL; FC RECEPTOR; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; PROLACTIN; SEX HORMONE; SINGLE STRANDED DNA; TUMOR NECROSIS FACTOR;

AUTOIMMUNE DISEASE; B LYMPHOCYTE; BONE MARROW; CELL MATURATION; DNA BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE DELETION; GENE MUTATION; GERMINAL CENTER; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENCE; LYMPHOID ORGAN; NONHUMAN; PERITONEAL CAVITY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; AUTOIMMUNITY; B-LYMPHOCYTES; HUMANS; IMMUNE TOLERANCE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE;

EID: 23744432462     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20050221     Document Type: Review

References (26)

1. Grimaldi, C.M., D.J. Michael, and B. Diamond. 2001. Cutting edge: expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus. J. Immunol. 167:1886-1890.
2. Bijl, M., G. Horst, P.C. Limburg, and C.G. Kallenberg. 2001. Expression of costimulatory molecules on peripheral blood lymphocytes of patients with systemic lupus erythematosus. Ann. Rheum. Dis. 60:523-526.
3. Koshy, M., D. Berger, and M.K. Crow. 1996. Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes. J. Clin. Invest. 98:826-837.
4. Peeva, E., D. Michael, J. Cleary, J. Rice, X. Chen, and B. Diamond. 2003. Prolactin modulates the naive B cell repertoire. J. Clin. Invest. 111:275-283.
5. Thien, M., T.G. Phan, S. Gardam, M. Amesbury, A. Basten, F. Mackay, and R. Brink. 2004. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity. 20:785-798.
6. Zhang, J., V. Roschke, K.P. Baker, Z. Wang, G.S. Alarcon, B.J. Fessler, H. Bastian, R.P. Kimberly, and T. Zhou. 2001. Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. J. Immunol. 166:6-10.
7. Kim, S.J., D. Gershov, X. Ma, N. Brot, and K.B. Elkon. 2002. I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. J. Exp. Med. 196:655-665.
8. Yurino, H., S. Ishikawa, T. Sato, K. Akadegawa, T. Ito, S. Ueha, H. Inadera, and K. Matsushima. 2004. Endocrine disruptors (environmental estrogens) enhance autoantibody production by B1 cells. Toxicol. Sci. 81:139-147.
9. Westhoff, C.M., A. Whittier, S. Kathol, J. McHugh, C. Zajicek, L.D. Shultz, and D.E. Wylie. 1997. DNA-binding antibodies from viable motheaten mutant mice: implications for B cell tolerance. J. Immunol. 159:3024-3033.
10. Caligaris-Cappio, F., M. Riva, L. Tesio, M. Schena, G. Gaidano, and L. Bergui. 1989. Human normal CD5+ B lymphocytes can be induced to differentiate to CD5- B lymphocytes with germinal center cell features. Blood. 73:1259-1263.
11. Mantovani, L., R.L. Wilder, and P. Casali. 1993. Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factors. J. Immunol. 151:473-488.
12. Pugh-Bernard, A.E., G.J. Silverman, A.J. Cappione, M.E. Villano, D.H. Ryan, R.A. Insel, and I. Sanz. 2001. Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J. Clin. Invest. 108:1061-1070.
13. Zeng, D., M.K. Lee, J. Tung, A. Brendolan, and S. Strober. 2000. Cutting edge: a role for CD1 in the pathogenesis of lupus in NZB/NZW mice. J. Immunol. 164:5000-5004.
14. Song, H., and J. Cerny. 2003. Functional heterogeneity of marginal zone B cells revealed by their ability to generate both early antibody-forming cells and germinal centers with hypermutation and memory in response to a T-dependent antigen. J. Exp. Med. 198:1923-1935.
15. Attanavanich, K., and J.F. Kearney. 2004. Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells. J. Immunol. 172:803-811.
16. William, J., C. Euler, S. Christensen, and M.J. Shlomchik. 2002. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science. 297:2066-2070.
17. Weller, S., M.C. Braun, B.K. Tan, A. Rosenwald, C. Cordier, M.E. Conley, A. Plebani, D.S. Kumararatne, D. Bonnet, O. Tournilhac, et al. 2004. Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood. 104:3647-3654.
18. Ray, S.K., C. Putterman, and B. Diamond. 1996. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. Proc. Natl. Acad. Sci. USA. 93:2019-2024.
19. Rice, J.S., J. Newman, C. Wang, D.J. Michael, and B. Diamond. 2005. Receptor editing in peripheral B cell tolerance. Proc.Natl. Acad. Sci. USA. 102:1608-1613.
20. Fukuyama, H., F. Nimmerjahn, and J.V. Ravetch. 2005. The inhibitory Fcgamma receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells. Nat. Immunol. 6:99-106.
21. Wardemann, H., S. Yurasov, A. Schaefer, J.W. Young, E. Meffre, and M.C. Nussenzweig. 2003. Predominant autoantibody production by early human B cell precursors. Science. 301:1374-1377.
22. Yurasov, S., H. Wardemann, J. Hammersen, M. Tsuiji, E. Meffre, V. Pascual, and M.C. Nussenzweig. 2005. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J. Exp. Med. 201:703-711.
23. Samuels, J., Y.S. Ng, C. Coupillaud, D. Paget, and E. Meffre. 2005. Impaired early B cell tolerance in patients with rheumatoid arthritis. J. Exp. Med. 201:1659-1667.
24. Leadbetter, E.A., I.R. Rifkin, and A. Marshak-Rothstein. 2003. Toll-like receptors and activation of autoreactive B cells. Curr. Dir. Autoimmun. 6:105-122.
25. van Es, J.H., F.H. Gmelig Meyling, W.R. van de Akker, H. Aanstoot, R.H. Derksen, and T. Logtenberg. 1991. Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus. J. Exp. Med. 173:461-470.
26. Debandt, M., O. Vittecoq, V. Descamps, L. Le, and O. Meyer. 2003. Anti-TNF-alphainduced systemic lupus syndrome. Clin. Rheumatol. 22:56-61.