Respiratory function of hemoglobin

New England Journal of Medicine

Volumn 338, Issue 4, 1998, Pages 239-247

  Hsia, Connie C W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYHEMOGLOBIN; DEOXYHEMOGLOBIN; GLUCOSE; LACTIC ACID; OXYHEMOGLOBIN;

ACID BASE BALANCE; ALTITUDE ACCLIMATIZATION; ANAEROBIC METABOLISM; CARBON MONOXIDE INTOXICATION; CONFORMATIONAL TRANSITION; DISORDERS OF ACID BASE BALANCE; ERYTHROCYTE METABOLISM; GLUCOSE METABOLISM; HEMOGLOBIN DETERMINATION; HUMAN; OXYGEN AFFINITY; OXYGEN SATURATION; OXYGEN TENSION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN CONFORMATION; REVIEW; SICKLE CELL ANEMIA; TEMPERATURE SENSITIVITY;

2,3-DIPHOSPHOGLYCERATE; ALTITUDE; HEMOGLOBINS; HUMANS; NITRIC OXIDE; OXYGEN; OXYHEMOGLOBINS; RESPIRATORY PHYSIOLOGY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032556983     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199801223380407     Document Type: Review

References (54)

1. Edsall JT. Understanding blood and hemoglobin: an example of international relations in science. Perspect Biol Med 1986;29:S107-S123.
2. Perkins JF Jr. Historical development of respiratory physiology. In: Fenn WO, Rahn H, eds. Handbook of physiology. Section 3. Respiration. Vol. 1. Washington, D.C.: American Physiological Society, 1964:1-62.
3. Bohr C, Hasselbalch KA, Krogh A. Ueber einen in biologischer Beziehung wichtigen Einfluss, den die Kohlensäurespannung des Blutes auf dessen Sauerstoffbindung übt. Skand Arch Physiol 1904;16:402-12.
4. Lehninger AL, Nelson DL, Cox MM. Principles of biochemistry. 2nd ed. New York: Worth, 1993.
5. Kelman GR, Nunn JF. Nomograms for correction of blood PO2, PCO2, pH, and base excess for time and temperature. J Appl Physiol 1966; 21:1484-90.
6. Severinghaus JW. Oxyhemoglobin dissociation curve correction for temperature and pH variation in human blood. J Appl Physiol 1958;12: 485-6.
7. Kelman GR. Digital computer subroutine for the conversion of oxygen tension into saturation. J Appl Physiol 1966;21:1375-6.
8. Monod J, Wyman J, Changeux J-P. On the nature of allosteric transitions: a plausible model. J Mol Biol 1965;12:88-118.
9. Edsall JT. Hemoglobin and the origins of the concept of allosterism. Fed Proc 1980;39:226-35.
10. Imai K. Allosteric effects in haemoglobin. Cambridge, England: Cambridge University Press, 1982.
11. Christiansen J, Douglas CG, Haldane JS. The absorption and dissociation of carbon dioxide by human blood. J Physiol (Lond) 1914;48:244-71.
12. 1, of carbonic acid in hemoglobin solutions and its relation to the existence of a combination of hemoglobin with carbon dioxide. J Biol Chem 1933;102: 611-34.
13. Johnson RL Jr, Ramanathan M. Buffer equilibria in the lungs. In: Seldin DW, Giebisch G, eds. The kidney: physiology and pathophysiology. 2nd ed.Vol. 1. New York: Raven Press, 1992:193-218.
14. Klocke RA. Mechanism and kinetics of the Haldane effect in human erythrocytes. J Appl Physiol 1973;35:673-81.
15. Forster RE. Buffering in blood, with emphasis on kinetics. In: Seldin DW, Giebisch G, eds. The kidney: physiology and pathophysiology. 2nd ed. Vol. 1. New York: Raven Press, 1992:171-92.
16. Kilmartin JV, Rossi-Bernardi L. Interaction of hemoglobin with hydrogen ions, carbon dioxide, and organic phosphates. Physiol Rev 1973; 53:836-90.
17. Bauer C, Schroder E. Carbamino compounds of haemoglobin in human adult and foetal blood. J Physiol (Lond) 1972;227:457-71.
18. Bunn HF, Jandl JH. Control of hemoglobin function within the red cell. N Engl J Med 1970;282:1414-21.
19. Lenfant C, Torrance J, English E, et al. Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels. J Clin Invest 1968;47:2652-6.
20. Jia L, Bonaventura C, Bonaventura J, Stamler JS. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 1996; 380:221-6.
21. Stamler JS, Jia L, Eu JP, et al. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science 1997;276:2034-7.
22. Johnson RL Jr. Oxygen transport. In: Willerson JT, Sanders CA, eds. Clinical cardiology. Vol. 1. New York: Grune & Stratton, 1977:74-84.
23. Johnson RL Jr, Jones NL, Heigenhauser G, Hsia CCW, Wagner PD. Determinants of gas exchange and acid-base balance during exercise. In: Rowell LB, Shepherd JT, eds. Handbook of physiology. Section 12. Exercise regulation and integration of multiple systems. New York: Oxford University Press, 1996:515-84.
24. Piiper J, Scheid P. Comparison of diffusion and perfusion limitations in alveolar gas exchange. Respir Physiol 1983;51:287-90.
25. 2 uptake in hypoxia. Respir Physiol 1981;46:193-208.
26. Dempsey JA. Exercise-induced arterial hypoxaemia in healthy human subjects at sea level. J Physiol (Lond) 1984;355:161-75.
27. Wagner PD, Gale GE, Moon RE, Torre-Bueno JR, Stolp BW, Saltzman HA. Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J Appl Phsyiol 1986;61:260-70.
28. Eaton JW, Skelton TD, Berger E. Survival at extreme altitude: protective effect of increased hemoglobin-oxygen affinity. Science 1974;183:743-4.
29. Dempsey JA, Thomson JM, Forster HV, Cerny FC, Chosy LW. HbO2 dissociation in man during prolonged work in chronic hypoxia. J Appl Physiol 1975;38:1022-9.
30. Moore LG, Brewer GJ. Beneficial effect of rightward hemoglobin-oxygen dissociation curve shift for short-term high-altitude adaptation. J Lab Clin Med 1981;98:145-54.
31. West JB, Hackett PH, Maret KH, et al. Pulmonary gas exchange on the summit of Mount Everest. J Appl Physiol 1983;55:678-87
32. Winslow RM, Samaja M, West JB. Red cell function at extreme altitude on Mount Everest. J Appl Physiol 1984;56:109-16.
33. Bunn HF, Forget BG. Hemoglobin: molecular, genetic, and clinical aspects. Philadelphia: W.B. Saunders, 1986.
34. Hebbel RP, Eaton JW, Kronenberg RS, Zanjani ED, Moore LG, Berger EM. Human llamas: adaptation to altitude in subjects with high hemoglobin oxygen affinity. J Clin Invest 1978;62:593-600.
35. Reynafarje C, Faura J, Villavicencio D, et al. Oxygen transport of hemoglobin in high-altitude animals (Camelidea). J Appl Physiol 1975;38: 806-10.
36. Heath D, Williams DR. Man at high altitude: The pathophysiology of acclimatization and adaptation. 2nd ed. Edinburgh, Scotland: Churchill Livingstone. 1981.
37. 2 affinity of animals living at high altitude. J Appl Physiol 1977;42:139-43.
38. Jessen TH, Weber RE, Fermi G, Tame J, Braunitzer G. Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein engineering. Proc Natl Acad Sci U S A 1991;88:6519-22.
39. Aste-Salazar H, Hurtado A. The affinity of hemoglobin for oxygen at sea level and at high altitudes. Am J Physiol 1944;142:733-43.
40. Chiodi H. Respiratory adaptations to chronic high altitude hypoxia. J Appl Physiol 1957;10:81-7.
41. 2-Hb dissociation curve and respiratory gas transport in man. Respir Physiol 1969;7:7-29.
42. Torrance JD, Lenfant C, Cruz J, Marticorena E. Oxygen transport mechanisms in residents at high altitude. Respir Physiol 1970;11:1-15.
43. Winslow RM, Monge C, Winslow NJ, Gibson CG, Whittembury J. Normal whole blood Bohr effect in Peruvian natives of high altitude. Respir Physiol 1985;61:197-208.
44. Samaja M, Veicsteinas A, Cerretelli P. Oxygen affinity of blood in altitude Sherpas. J Appl Physiol 1979;47:337-41.
45. 2 gradients in Tibetan than Han residents of Lhasa (3658 m). Respir Physiol 1996;103:75-82.
46. Beall CM, Goldstein MC. Hemoglobin concentration of pastoral nomads permanently resident at 4,850-5,450 meters in Tibet. Am J Phys Anthropol 1987;73:433-8.
47. Winslow RM. Relationship between erythropoiesis and ventilation in high altitude natives. In: Lahiri S, Cherniack NS, Fitzgerald RS, eds. Response and adaptation to hypoxia: organ to organelle. New York: Oxford University Press, 1991:143-53.
48. Monge C, Bonavia D, León-Velarde F, Arregui A. High altitude populations in Nepal and the Andes. In: Sutton JR, Coates G, Remmers JE, eds. Hypoxia: the adaptations. Toronto: B.C. Decker, 1990:53-8.
49. Frisancho AR. Origins of differences in hemoglobin concentration between Himalayan and Andean populations. Respir Physiol 1988;72:13-8.
50. Gill SJ, Benedict RC, Fall L, Spokane R, Wyman J. Oxygen binding to sickle cell hemoglobin. J Mol Biol 1979;130:175-89.
51. Ueda Y, Nagel RL, Bookchin RM. An increased Bohr effect in sickle cell anemia. Blood 1979;53:472-80.
52. Roughton FJW. Transport of oxygen and carbon dioxide. In: Fenn WO, Rahn H, eds. Handbook of physiology. Section 3. Respiration. Vol. 1. Washington, D.C.: American Physiological Society, 1964:767-825.
53. Grote J, Dall P, Oltmanns K, Stolp W. The effect of increased blood carbon monoxide levels on the hemoglobin oxygen affinity during pregnancy. In: Vaupel P, Zander R, Bruley DF, eds. Oxygen transport to tissue XV. Vol. 345 of Advances in experimental medicine and biology. New York: Plenum Press, 1994:145-50.
54. Mitchell JH, Wildenthal K, Johnson RL Jr. The effects of acid-base disturbances on cardiovascular and pulmonary function. Kidney Int 1972; 1:375-89.