Increased expression and hotspot mutations of the multidrug efflux transporter, CDR1 in azole-resistant Candida albicans isolates from vaginitis patients

FEMS Microbiology Letters

Volumn 249, Issue 2, 2005, Pages 283-289

  Chung, Yeng Looi ^a,c   D'Silva, Emily Christine ^a   Heng, Fong Seow ^a   Rosli, Rozita ^a   Kee, Peng Ng ^b   Pei, Pei Chong ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Azole antifungals; Candida albicans; Candida glabrata; CDR1, MDR1; Mutation hotspots

Indexed keywords

ABC TRANSPORTER A1; CLOTRIMAZOLE; KETOCONAZOLE; MULTIDRUG RESISTANCE PROTEIN 1;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDA GLABRATA; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA SEQUENCE; FUNGAL STRAIN; FUNGUS ISOLATION; GENE EXPRESSION REGULATION; GENE MUTATION; GENE OVEREXPRESSION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; START CODON; STRAIN DIFFERENCE; UPREGULATION; VAGINITIS;

ANTIFUNGAL AGENTS; BASE SEQUENCE; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDIASIS; CLOTRIMAZOLE; DNA PRIMERS; DRUG RESISTANCE, FUNGAL; FEMALE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; KETOCONAZOLE; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; VAGINITIS;

CANDIDA ALBICANS; CANDIDA GLABRATA;

EID: 23644457170     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.femsle.2005.06.036     Document Type: Article

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