Transcription initiation of genes associated with azole resistance in Candida albicans

Medical Mycology

Volumn 40, Issue 1, 2002, Pages 73-81

  Harry, J B ^a   Song, J L ^a   Lyons, C N ^a   White, Theodore C ^a  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

Candida albicans; Transcription initiation

Indexed keywords

ABC TRANSPORTER; ANTIFUNGAL AGENT; CANDIDA DRUG RESISTANCE 1; CANDIDA DRUG RESISTANCE 2; COMPLEMENTARY DNA; ELONGATION FACTOR 3; GLYCOPROTEIN P; OLIGONUCLEOTIDE; PYRROLE DERIVATIVE; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATE; CANDIDA ALBICANS; CLONING; DNA SEQUENCE; GENE AMPLIFICATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; IMMUNE DEFICIENCY; MOLECULAR MECHANICS; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; THRUSH; TRANSCRIPTION REGULATION; YEAST;

BACTERIA (MICROORGANISMS); CANDIDA; CANDIDA ALBICANS; EUKARYOTA;

EID: 0036177187     PISSN: 13693786     EISSN: None     Source Type: Journal    
DOI: 10.1080/714031077     Document Type: Article

References (38)

1. High prevalence of antifungal resistance in Candida spp. from patients with AIDS
2. Candidemia in allogeneic blood and marrow transplant recipients: Evolution of risk factors after the adoption of prophylactic fluconazole
3. Myelofibrosis complicated by infection due to Candida albicans: Emergence of resistance to antifungal agents during therapy
4. Isolation and characterization of fluconazole and amphotericin B-resistant Candida albicans from blood of two patients with leukemia
5. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
6. Molecular and phenotypic analyses of Candida albicans fluconazole-resistant clinical isolates
7. Analysis of resistance mechanisms to azole antifungal agents in sequential Candida albicans clinical isolates from AIDS patients
8. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains
9. Functional characterisation and expression studies of CDR1, a multidrug transporter from a pathogenic yeast Candida albicans, belonging to ABC transporter superfamily
10. Distinct patterns of gene expression associated with development of fluconazole resistance in serial Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis
11. Expression of CDR1, MDR1 and ERG16 genes by RT-PCR from azole-resistant isolates of Candida albicans from pediatric HIV patients
12. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involved specific multidrug transporters
13. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
14. Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation
15. Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor
16. Resistance of Candida albicans to azole antifungal agents
17. Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: Possible role for drug efflux in drug resistance
18. Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
19. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: Characterization of CDR2, a new multidrug ABC transporter gene
20. Stable azole drug resistance associated with a substrain of Candida albicans from an HIV-infected patient
21. The R467K amino acid substitution in Candida albicans sterol 14 alpha-demethylase causes drug resistance through reduced affinity
22. Regulation of ATP-binding cassette (ABC) transporter genes in Candida albicans
23. CDR1, a multidrug resistance gene from Candida albicans, contains multiple regulatory domains in its promoter and the distal AP-1 element mediates its induction by miconazole
24. Regulation of the major facilitator gene CaMDR1 in Candida albicans
25. The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans
26. Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors
27. Transcriptional analyses of antifunfal drug resistance in Candida albicans
28. Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate
29. Isolation and sequence analysis of the gene encoding translation elongation factor 3 from Candida albicans
30. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
31. The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14α demethylase in Candida albicans
32. Nucleotide sequence of cytochrome P450 L1A1 (lanosterol 14 alpha-demethylase) from Candida albicans
33. Promoters, activator proteins, and the mechanism of transcriptional initiation in yeast
34. Overlapping coding regions and transcriptional units of two essential chromosomal genes (CCT8, TRP1) in the fungal pathogen Candida albicans
35. Gene analysis of an NADP-linked isocitrate dehydrogenase localized in peroxisomes of the n-alkane-assimilating yeast Candida tropicalis
36. Characterization of the intron-containing citrate synthase gene from the alkanotrophic yeast Candida tropicalis: Cloning and expression in Saccharomyces cerevisiae