-
1
-
-
0033596065
-
Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate
-
Leflunomide Rheumatoid Arthritis Investigators Group
-
Strand V, Cohen S, Schiff M, et al. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. Arch Intern Med 1999;159:2542-50.
-
(1999)
Arch Intern Med
, vol.159
, pp. 2542-2550
-
-
Strand, V.1
Cohen, S.2
Schiff, M.3
-
2
-
-
0033053835
-
Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double-blind, randomised, multicentre trial
-
European Leflunomide Study Group
-
Smolen JS, Kalden JR, Scott DL, et al. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group. Lancet 1999;353:259-66.
-
(1999)
Lancet
, vol.353
, pp. 259-266
-
-
Smolen, J.S.1
Kalden, J.R.2
Scott, D.L.3
-
3
-
-
6744262231
-
A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis
-
Emery P, Breedveld FC, Lemmel EM, et al. A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis. Rheumatology Oxford 2000;39:655-65.
-
(2000)
Rheumatology Oxford
, vol.39
, pp. 655-665
-
-
Emery, P.1
Breedveld, F.C.2
Lemmel, E.M.3
-
4
-
-
0038657686
-
Leflunomide for the treatment of rheumatoid arthritis: A systematic review and meta analysis
-
Osiri M, Shea B, Robinson V, et al. Leflunomide for the treatment of rheumatoid arthritis: A systematic review and meta analysis. J Rheumatol 2003;30:1182-96.
-
(2003)
J Rheumatol
, vol.30
, pp. 1182-1196
-
-
Osiri, M.1
Shea, B.2
Robinson, V.3
-
5
-
-
2342627946
-
Leflunomide in the treatment of rheumatoid arthritis
-
Li EK, Tam LS, Tomlinson B. Leflunomide in the treatment of rheumatoid arthritis. Clin Ther 2004;26:447-59.
-
(2004)
Clin Ther
, vol.26
, pp. 447-459
-
-
Li, E.K.1
Tam, L.S.2
Tomlinson, B.3
-
6
-
-
2642558895
-
Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis: A multinational, double-blind, randomized, placebo-controlled clinical trial
-
Kaltwasser JP, Nash P, Gladman D, et al. Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis: a multinational, double-blind, randomized, placebo-controlled clinical trial. Arthritis Rheum 2004;50:1939-50.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1939-1950
-
-
Kaltwasser, J.P.1
Nash, P.2
Gladman, D.3
-
7
-
-
2542572458
-
Practical management of rheumatoid arthritis patients treated with leflunomide. An international expert panel meeting
-
Smolen JS. Practical management of rheumatoid arthritis patients treated with leflunomide. An international expert panel meeting. J Rheumatol 2004;31 Suppl 71:1-12.
-
(2004)
J Rheumatol
, vol.31
, Issue.SUPPL. 71
, pp. 1-12
-
-
Smolen, J.S.1
-
8
-
-
2542538995
-
The efficacy of leflunomide monotherapy in rheumatoid arthritis: Towards the goals of disease modifying antirheumatic drug therapy
-
Smolen JS, Emery P, Kalden JR, et al. The efficacy of leflunomide monotherapy in rheumatoid arthritis: towards the goals of disease modifying antirheumatic drug therapy. J Rheumatol 2004;31 Suppl 71:13-20.
-
(2004)
J Rheumatol
, vol.31
, Issue.SUPPL. 71
, pp. 13-20
-
-
Smolen, J.S.1
Emery, P.2
Kalden, J.R.3
-
9
-
-
2542618299
-
Lefunomide in combination therapy
-
Kalden JR, Smolen JS, Emery P, et al. Lefunomide in combination therapy. J Rheumatol 2004;31 Suppl 71:25-30.
-
(2004)
J Rheumatol
, vol.31
, Issue.SUPPL. 71
, pp. 25-30
-
-
Kalden, J.R.1
Smolen, J.S.2
Emery, P.3
-
10
-
-
2542613661
-
Leflunomide: A manageable safety profile
-
van Riel PL, Smolen JS, Emery P, et al. Leflunomide: a manageable safety profile. J Rheumatol 2004;31 Suppl 71:21-4.
-
(2004)
J Rheumatol
, vol.31
, Issue.SUPPL. 71
, pp. 21-24
-
-
Van Riel, P.L.1
Smolen, J.S.2
Emery, P.3
-
11
-
-
0036274556
-
Infliximab and leflunomide combination therapy in rheumatoid arthritis: An open-label study
-
Kiely PD, Johnson DM. Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study. Rheumatology Oxford 2002;41:631-7.
-
(2002)
Rheumatology Oxford
, vol.41
, pp. 631-637
-
-
Kiely, P.D.1
Johnson, D.M.2
-
12
-
-
0029591467
-
The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis
-
Cherwinski HM, Cohn RG, Cheung P, et al. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther 1995;275:1043-9.
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 1043-1049
-
-
Cherwinski, H.M.1
Cohn, R.G.2
Cheung, P.3
-
13
-
-
0029050136
-
Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide
-
Greene S, Watanabe K, Braatz-Trulson J, Lou L. Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide. Biochem Pharmacol 1995;50:861-7.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 861-867
-
-
Greene, S.1
Watanabe, K.2
Braatz-Trulson, J.3
Lou, L.4
-
14
-
-
0032555586
-
Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans
-
Ruckemann k, Fairbanks LD, Carrey EA, et al. Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans. J Biol Chem 1998;273:21682-91.
-
(1998)
J Biol Chem
, vol.273
, pp. 21682-21691
-
-
Ruckemann, K.1
Fairbanks, L.D.2
Carrey, E.A.3
-
15
-
-
0037378668
-
Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis
-
Cutolo M, Sulli A, Ghiorzo P, Pizzorni C, Craviotto C, Villagio B. Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis. Ann Rheum Dis 2003;62:297-302.
-
(2003)
Ann Rheum Dis
, vol.62
, pp. 297-302
-
-
Cutolo, M.1
Sulli, A.2
Ghiorzo, P.3
Pizzorni, C.4
Craviotto, C.5
Villagio, B.6
-
16
-
-
0030827614
-
Anti-tumor necrosis factor alpha therapy of rheumatoid arthritis. Mechanism of action
-
Feldmann M, Brennan F, Paleolog E, Taylor P, Maini RN. Anti-tumor necrosis factor alpha therapy of rheumatoid arthritis. Mechanism of action. Eur Cytokine Netw 1997;8:297-300.
-
(1997)
Eur Cytokine Netw
, vol.8
, pp. 297-300
-
-
Feldmann, M.1
Brennan, F.2
Paleolog, E.3
Taylor, P.4
Maini, R.N.5
-
17
-
-
0037768899
-
The therapeutic potential of TNF-alpha blockade in rheumatoid arthritis
-
Paleolog E. The therapeutic potential of TNF-alpha blockade in rheumatoid arthritis. Expert Opin Investig Drugs 2003;12:1087-95.
-
(2003)
Expert Opin Investig Drugs
, vol.12
, pp. 1087-1095
-
-
Paleolog, E.1
-
19
-
-
0036201985
-
Long term anti-tumour necrosis factor alpha monotherapy in rheumatoid arthritis: Effect on radiological course and prognostic value of markers of cartilage turnover and endothelial activation
-
den Broeder AA, Joosten LA, Saxne T, et al. Long term anti-tumour necrosis factor alpha monotherapy in rheumatoid arthritis: effect on radiological course and prognostic value of markers of cartilage turnover and endothelial activation. Ann Rheum Dis 2002;61:311-8.
-
(2002)
Ann Rheum Dis
, vol.61
, pp. 311-318
-
-
Den Broeder, A.A.1
Joosten, L.A.2
Saxne, T.3
-
20
-
-
0033765449
-
Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis
-
Schiff MH. Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis. Ann Rheum Dis 2000;59 Suppl 1:i103-8.
-
(2000)
Ann Rheum Dis
, vol.59
, Issue.SUPPL. 1
-
-
Schiff, M.H.1
-
21
-
-
0036402455
-
Evidence for the biological modulation of IL-1 activity: The role of IL-1Ra
-
Dayer JM. Evidence for the biological modulation of IL-1 activity: the role of IL-1Ra. Clin Exp Rheumatol 2002;20 Suppl 27:S14-20.
-
(2002)
Clin Exp Rheumatol
, vol.20
, Issue.SUPPL. 27
-
-
Dayer, J.M.1
-
22
-
-
1842629562
-
The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis
-
Hansen KE, Cush J, Singhal A, et al. The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis. Arthritis Rheum 2004;51:228-32.
-
(2004)
Arthritis Rheum
, vol.51
, pp. 228-232
-
-
Hansen, K.E.1
Cush, J.2
Singhal, A.3
-
23
-
-
0006074511
-
Efficacy and safety of remicade (infliximab) plus arava (leflunomide) in rheumatoid arthritis (RA)
-
Patel S, Bergen W, Kraemer A, Keenan GF. Efficacy and safety of remicade (infliximab) plus arava (leflunomide) in rheumatoid arthritis (RA) [abstract]. Arthritis Rheum 2001;44 Suppl:S84.
-
(2001)
Arthritis Rheum
, vol.44
, Issue.SUPPL.
-
-
Patel, S.1
Bergen, W.2
Kraemer, A.3
Keenan, G.F.4
-
24
-
-
80053479985
-
A French multicenter retrospective study on the efficacy and safety of infliximab in association with DMARDs other than methotrexate
-
Perdriger A, Combe B, Kuntz JL, et al. A French multicenter retrospective study on the efficacy and safety of infliximab in association with DMARDs other than methotrexate [abstract]. Ann Rheum Dis 2004;50 Suppl:488.
-
(2004)
Ann Rheum Dis
, vol.50
, Issue.SUPPL.
, pp. 488
-
-
Perdriger, A.1
Combe, B.2
Kuntz, J.L.3
-
25
-
-
2342571658
-
Safety of leflunomide plus infliximab combination therapy in rheumatoid arthritis
-
Godinho F, Godfrin B, El Mahou S, Navaux F, Zabraniecki L, Cantagrel A. Safety of leflunomide plus infliximab combination therapy in rheumatoid arthritis. Clin Exp Rheumatol 2004;22:328-30.
-
(2004)
Clin Exp Rheumatol
, vol.22
, pp. 328-330
-
-
Godinho, F.1
Godfrin, B.2
El Mahou, S.3
Navaux, F.4
Zabraniecki, L.5
Cantagrel, A.6
-
26
-
-
19944413027
-
Effectiveness and safety of infliximab combined with leflunomide in chronic polyarthritis
-
Infliximab and Leflunomide Study Group
-
Ortiz Garcia AM, Gonzalez-Alvaro I, Rosello Pardo R, Carmona L, Fabregas Canales MD, Monteagudo Saez I. Infliximab and Leflunomide Study Group. Effectiveness and safety of infliximab combined with leflunomide in chronic polyarthritis [letter]. Clin Exp Rheumatol 2004;22:790.
-
(2004)
Clin Exp Rheumatol
, vol.22
, pp. 790
-
-
Ortiz Garcia, A.M.1
Gonzalez-Alvaro, I.2
Rosello Pardo, R.3
Carmona, L.4
Fabregas Canales, M.D.5
Monteagudo Saez, I.6
-
27
-
-
2542558357
-
Safety and efficacy of leflunomide and infliximab in rheumatoid arthritis (RA) patients
-
Struppler CI, Thies W, Schattenkirchner M, Kellner H. Safety and efficacy of leflunomide and infliximab in rheumatoid arthritis (RA) patients [abstract]. Ann Rheum Dis 2002;61:S388.
-
(2002)
Ann Rheum Dis
, vol.61
-
-
Struppler, C.I.1
Thies, W.2
Schattenkirchner, M.3
Kellner, H.4
-
28
-
-
10444244903
-
Induction of antinuclear antibodies in patients with rheumatoid arthritis treated with infliximab and leflunomide
-
Bingham SJ, Buch MH, Kerr MA, Emery P, Valadao Barcelos AT. Induction of antinuclear antibodies in patients with rheumatoid arthritis treated with infliximab and leflunomide. Arthritis Rheum 2004;50:4072-3.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 4072-4073
-
-
Bingham, S.J.1
Buch, M.H.2
Kerr, M.A.3
Emery, P.4
Valadao Barcelos, A.T.5
-
29
-
-
18744408791
-
The influence of previous and concomitant leflunomide on the efficacy and safety of infliximab therapy in patients with rheumatoid arthritis; a longitudinal observational study
-
Flendrie M, Creemers MC, Welsing PM, van Riel PL. The influence of previous and concomitant leflunomide on the efficacy and safety of infliximab therapy in patients with rheumatoid arthritis; a longitudinal observational study. Rheumatology Oxford 2005;44:472-8.
-
(2005)
Rheumatology Oxford
, vol.44
, pp. 472-478
-
-
Flendrie, M.1
Creemers, M.C.2
Welsing, P.M.3
Van Riel, P.L.4
-
30
-
-
0038302433
-
Treatment of psoriatic arthritis with TNF alpha-antagonists
-
Antoni C, Manger B. Treatment of psoriatic arthritis with TNF alpha-antagonists. Z Rheumatol 2003;62:235-9.
-
(2003)
Z Rheumatol
, vol.62
, pp. 235-239
-
-
Antoni, C.1
Manger, B.2
-
31
-
-
0348109372
-
Adalimumab, a fully human anti tumor necrosis factor-alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: Results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis)
-
Furst DE, Schiff MH, Fleischmann RM, et al. Adalimumab, a fully human anti tumor necrosis factor-alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis). J Rheumatol 2003;30:2563-71.
-
(2003)
J Rheumatol
, vol.30
, pp. 2563-2571
-
-
Furst, D.E.1
Schiff, M.H.2
Fleischmann, R.M.3
-
32
-
-
1842425913
-
Concomitant medication use in a large, international, multicenter, placebo controlled trial of anakinra, a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis
-
Tesser J, Fleischmann R, Dore R, et al. Concomitant medication use in a large, international, multicenter, placebo controlled trial of anakinra, a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis. J Rheumatol 2004;31:649-54.
-
(2004)
J Rheumatol
, vol.31
, pp. 649-654
-
-
Tesser, J.1
Fleischmann, R.2
Dore, R.3
-
33
-
-
7044279878
-
Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: Diagnostic value, associations with radiological progression rate, and extra-articular manifestations
-
De Rycke L, Peene I, Hoffman IE, et al. Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations. Ann Rheum Dis 2004;63:1587-93.
-
(2004)
Ann Rheum Dis
, vol.63
, pp. 1587-1593
-
-
De Rycke, L.1
Peene, I.2
Hoffman, I.E.3
-
34
-
-
0036846269
-
Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: The COBRA study
-
Garnero P, Landewe R, Boers M, et al. Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: the COBRA study. Arthritis Rheum 2002;46:2847-56.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 2847-2856
-
-
Garnero, P.1
Landewe, R.2
Boers, M.3
-
35
-
-
17144394574
-
A comparison of clinical and radiological outcomes of four treatment strategies for early rheumatoid arthritis: Results of the BeSt trial
-
BeSt Trial Group Berlin, Germany, 0P0001. [Internet]
-
de Vries-Bouwstra JK, Goekoop-Ruiterman YPM, Van Zeben D, et al. BeSt Trial Group. A comparison of clinical and radiological outcomes of four treatment strategies for early rheumatoid arthritis: results of the BeSt trial [abstract]. EULAR Meeting, Berlin, Germany, 2004: 0P0001. [Internet] Accessed April 14, 2005. Available from http://www.eular.org/index.cfm?framePage=/ eular2004.cfm.
-
(2004)
EULAR Meeting
-
-
De Vries-Bouwstra, J.K.1
Goekoop-Ruiterman, Y.P.M.2
Van Zeben, D.3
-
36
-
-
10744223002
-
Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: Double-blind randomized controlled trial
-
Klareskog L, van der Heijde D, de Jager JP, et al. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomized controlled trial. Lancet 2004;363:675-81.
-
(2004)
Lancet
, vol.363
, pp. 675-681
-
-
Klareskog, L.1
Van Der Heijde, D.2
De Jager, J.P.3
-
38
-
-
0037103348
-
Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis
-
Cunnane G, Warnock M, Fye KH, Daikh DI. Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis. Arthritis Rheum 2002;47:445-9.
-
(2002)
Arthritis Rheum
, vol.47
, pp. 445-449
-
-
Cunnane, G.1
Warnock, M.2
Fye, K.H.3
Daikh, D.I.4
-
39
-
-
0036101615
-
Etanercept and infliximab associated with cutaneous vasculitis
-
McCain ME, Quinet RJ, Davis WE. Etanercept and infliximab associated with cutaneous vasculitis. Rheumatology Oxford 2002;41:116-7.
-
(2002)
Rheumatology Oxford
, vol.41
, pp. 116-117
-
-
McCain, M.E.1
Quinet, R.J.2
Davis, W.E.3
-
40
-
-
5044232705
-
Vasculitis associated with the use of leflunomide
-
Macdonald J, Zhong T, Lazarescu A, Gan BS, Harth M. Vasculitis associated with the use of leflunomide. J Rheumatol 2004;31:2076-8.
-
(2004)
J Rheumatol
, vol.31
, pp. 2076-2078
-
-
Macdonald, J.1
Zhong, T.2
Lazarescu, A.3
Gan, B.S.4
Harth, M.5
-
41
-
-
0141865721
-
The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with nonsteroidal antiinflammatory drugs: A multinational perspective
-
Mockenhaupt M, Kelly JP, Kaufman D, Stern RS; SCAR Study Group. The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with nonsteroidal antiinflammatory drugs: a multinational perspective. J Rheumatol 2003;30:2234-40.
-
(2003)
J Rheumatol
, vol.30
, pp. 2234-2240
-
-
Mockenhaupt, M.1
Kelly, J.P.2
Kaufman, D.3
Stern, R.S.4
|