Vasculitis associated with the use of leflunomide

Journal of Rheumatology

Volumn 31, Issue 10, 2004, Pages 2076-2078

  MacDonald, Jeannie ^a   Zhong, Toni ^a   Lazarescu, Adriana ^b   Gan, Bing Siang ^a   Harth, Manfred ^b,c  

^a Div of Plast and Reconstr Surgery   (Russian Federation)

^b Division of Rheumatology   (Canada)

^c ST JOSEPH S HEALTH CENTRE   (Canada)

Author keywords

IgA nephropathy; Leflunomide; Rheumatoid arthritis; Vasculitis

Indexed keywords

CIPROFLOXACIN; CLINDAMYCIN; CYCLOPHOSPHAMIDE; LEFLUNOMIDE; PREDNISONE;

AGED; ALOPECIA; ARTICLE; CASE REPORT; DIARRHEA; DISEASE SEVERITY; FEMALE; HUMAN; HYPERTENSION; IMMUNOGLOBULIN A NEPHROPATHY; LIVER TOXICITY; PRIORITY JOURNAL; RARE DISEASE; RASH; RHEUMATOID ARTHRITIS; VASCULITIS;

AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, RHEUMATOID; FEMALE; HUMANS; ISOXAZOLES; MALE; MIDDLE AGED; TREATMENT OUTCOME; VASCULITIS;

EID: 5044232705     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Smolen JS, Kalden JR, Scott DL, et al. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomized, multicentre trial. European Leflunomide Study Group. Lancet 1999;353:259-66.
2. Emery P, Breedveld FC, Lemmel EM, et al. A comparison of the efficacy and safety of leflunomide and methotrexate for-the treatment of rheumatoid arthritis. Rheumatology Oxford 2000;39:655-65.
3. Cohen S, Cannon GW, Schiff M, et al. Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group. Arthritis Rheum 2001;44:1984-92.
4. Bruyn GA, Griep EN, Korff KJ. Leflunomide for active rheumatoid arthritis [letter]. Lancet 1999;353:1883.
5. Holm EA, Balslev E, Jemec GB. Vasculitis occurring during leflunomide therapy. Dermatology 2001;203:258-9.
6. Chan AT, Bradlow A, McNally J. Leflunomide induced vasculitis - a dose-response relationship [letter]. Rheumatology Oxford 2003;42:492-3.
7. Vollertsen RS, Conn DL. Vasculitis associated with rheumatoid arthritis. Rheum Dis Clin North Am 1990;16:445-61.
8. Donadio JV, Grande JP. IgA nephropathy. N Engl J Med 2002;347:738-48.
9. Bruyn GA, Veenstra RP, Halma C, Grond J. Anti-glomerular basement membrane antibody-associated renal failure in a patient with leflunomide-treated rheumatoid arthritis [letter]. Arthritis Rheum 2003;48:1164-5.
10. Brogan BL, Olsen NJ. Drug-induced rheumatic syndromes. Curr Opin Rheumatol 2003;15:76-80.