Dehydroepiandrosterone: An inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage

Archives of Surgery

Volumn 133, Issue 12, 1998, Pages 1281-1288

  Angele, Martin K ^a   Catania, Robert A ^a   Ayala, Alfred ^a   Cioffi, William G ^a   Bland, Kirby I ^a   Chaudry, Irshad H ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRASTERONE; STEROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; CONTROLLED STUDY; DRUG EFFECT; HORMONAL REGULATION; IMMUNE DEFICIENCY; IMMUNE RESPONSE; INJURY; MACROPHAGE FUNCTION; MORTALITY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SEPSIS; SURVIVAL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; DEHYDROEPIANDROSTERONE; HEMORRHAGE; MACROPHAGES; MALE; MICE; MICE, INBRED C3H; MONOKINES; SEPSIS; SPLEEN; SURVIVAL RATE; WOUNDS AND INJURIES;

EID: 0032407998     PISSN: 00040010     EISSN: None     Source Type: Journal    
DOI: 10.1001/archsurg.133.12.1281     Document Type: Article

References (21)

1. Zellweger R, Ayala A, DeMaso CM, Chaudry IH. Trauma-hemorrhage causes prolonged depression in cellular immunity. Shock. 1995;4:149-153.
2. Xu YX, Ayala A, Chaudry IH. Prolonged immunodepression after trauma and hemorrhagic shock. J Trauma. 1998;44:335-341.
3. Stephan RN, Kupper TS, Geha AS, Baue AS, Chaudry IH. Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis. Arch Surg. 1987;122:62-68.
4. Angele MK, Wichmann MW, Ayala A, Cioffi WG, Chaudry IH. Testosterone receptor blockade after hemorrhage in males: restoration of the depressed immune functions and improved survival following subsequent sepsis. Arch Surg. 1997;132:1207-1214.
5. Wichmann MW, Ayala A, Chaudry IH. Male sex steroids are responsible for depressing macrophage immune function after trauma-hemorrhage. Am J Physiol. 1997;273:C1335-C1340.
6. Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH. Testosterone: the culprit for producing splenocyte immune depression following trauma-hemorrhage. Am J Physiol. 1998;274:C1530-C1536.
7. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH. Enhanced immune responses in females as opposed to decreased responses in males following hemorrhagic shock. Cytokine. 1996;8:853-863.
8. Zellweger R, Zhu X, Wichmann MW, Ayala A, DeMaso CM, Chaudry IH. Prolactin administration following hemorrhagic shock improves macrophage cytokine release capacity and decreases mortality from subsequent sepsis. J Immunol. 1996;157:5748-5754.
9. Ebeling P, Koivisto VA. Physiological importance of dehydroepiandrosterone. Lancet 1994;343:1479-1481.
10. Blauer KL, Poth M, Rogers WM, Bernton EW. Dehydroepiandrosterone antagonizes the suppressive effects of dexamethasone on lymphocyte proliferation. Endocrinology. 1991;129:3174-3179.
11. Meikle AW, Dorchuck RW, Araneo BA, et al. The presence of a dehydroepiandrosterone-specific receptor binding complex in murine T cells. J Steroid Biochem Mol Biol. 1992;42:293-304.
12. Araneo BA, Shelby J, Li GZ, Ku W, Daynes RA. Administration of dehydroepiandrosterone to burned mice preserves normal immunologic competence. Arch Surg. 1993;128:318-325.
13. Baker CC, Chaudry IH, Gaines HO, Baue AE. Evaluation of factors affecting mortality rate after sepsis in murine cecal ligation and puncture model. Surgery. 1983;94:331-335.
14. Angele MK, Ayala A, Monfils BA, Cioffi WG, Bland KI, Chaudry IH. Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage. J Trauma. 1998;44:78-85.
15. Ayala A, Deol ZK, Lehman DL, Herdon CD, Chaudry IH. Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-gamma release while increasing IL-4/IL-10 production. J Surg Res. 1994;56:579-585.
16. Ihle JN, Keller J, Greenberger JS, Henderson L, Yetter RA, Morse HC. Phenotypic characteristics of cell lines requiring IL-3 for growth. J Immunol. 1982;129:1377-1383.
17. Chaudry IH, Ayala A. Immunomodulation following hemorrhage and resuscitation. In: Chaudry IH, Ayala A, eds. Immunological Aspects of Hemorrhage. Austin, Tex: RG Landes Co; 1992:104-127.
18. Wichmann MW, Angele MK, Ayala A, Cioffi WG, Chaudry IH. Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. Shock. 1997;8:242-248.
19. Paavonen T, Anderson LC, Adlercreutz H. Sex hormone regulation of in vitro immune responses. J Exp Med. 1981;154:1935-1945.
20. Loria RM, Regelson W, Padgett DA. Immune response facilitation and resistance to virus and bacterial infections with dehydroepiandrosterone (DHEA). In: Kalimi M, Regelson W, eds. The Biologic Role of Dehydroepiandrosterone (DHEA). New York, NY: Walter De Gruyter; 1990:107-130.
21. Araneo BA, Daynes RA. Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury. Endocrinology. 1995;136:393-401.