Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients

Critical Care Medicine

Volumn 31, Issue 6, 2003, Pages 1722-1729

  Spolarics, Zoltán ^a   Siddiqi, Muhammad ^a   Siegel, John H ^a   Garcia, Zenaida C ^a   Stein, Dana S ^a   Denny, Thomas ^a   Deitch, Edwin A ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Adult respiratory distress syndrome; Interferon ; Interleukin 12; Interleukin 4; Interleukin 6; Sepsis; Systemic inflammatory response syndrome; T lymphocytes; Th1 Th2 balance; Trauma; Tumor necrosis factor

Indexed keywords

CD14 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 4; INTERLEUKIN 6; IONOMYCIN; LIPOPOLYSACCHARIDE; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; BRONCHITIS; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; EMERGENCY HEALTH SERVICE; FLOW CYTOMETRY; GLASGOW COMA SCALE; HUMAN; HUMAN CELL; INFLAMMATION; INJURY; INJURY SCALE; LEUKOCYTE; MALE; MONOCYTE; NEGRO; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEPSIS; STATISTICAL ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ADULT; CASE-CONTROL STUDIES; CYTOKINES; FLOW CYTOMETRY; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; INTERLEUKIN-6; LOGISTIC MODELS; MALE; MONOCYTES; PROSPECTIVE STUDIES; RESPIRATORY DISTRESS SYNDROME, ADULT; SEPSIS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA; WOUNDS AND INJURIES;

EID: 0038468348     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000063579.43470.AA     Document Type: Article

References (49)

1. Remick DG, Newcomb DE, Bolgos GL, et al: Comparison of the mortality and inflammatory response of two models of sepsis: Lipopolysaccharide vs. cecal ligation and puncture. Shock 2000; 13:110-116
2. Ebong S J, Call DR, Bolgos G, et al: Immunopathologic responses to non-lethal sepsis. Shock 1999; 12:118-126
3. Ebong SJ, Goyert SM, Nemzek JA, et al: Critical role of CD14 for production of proinflammatory cytokines and cytokine inhibitors during sepsis with failure to alter morbidity or mortality. Infect Immun 2001; 69:2099-2106
4. Kahlke V, Angele MK, Ayala A, et al: Immune dysfunction following trauma-haemorrhage: Influence of gender and age. Cytokine 2000; 12:69-77
5. Schwacha MG, Chung CS, Ayala A, et al: Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury. Am J Physiol Cell Physiol 2002; 282:C263-C270
6. Song GY, Chung CS, Chaudry IH, et al: IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis. Surgery 2000; 128:133-138
7. Leon LR, White AA, Kluger MJ: Role of IL-6 and TNF in thermoregulation and survival during sepsis in mice. Am J Physiol 1998; 275:R269-R277
8. Walley KR, Lukacs NW, Standiford TJ, et al: Balance of inflammatory cytokines related to severity and mortality of murine sepsis. Infect Immun 1996; 64:4733-4738
9. Villa P, Sartor G, Angelini M, et al: Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin. Clin Diagn Lab Immunol 1995; 2:549-553
10. Dinarello CA: Proinflammatory cytokines. Chest 2000; 118:503-508
11. Mayers I, Johnson D: The nonspecific inflammatory response to injury. Can J Anaesth 1998; 45:871-879
12. Oberholzer A, Oberholzer C, Moldawer LL: Cytokine signaling: Regulation of the immune response in normal and critically ill states. Crit Care Med 2000; 28:N3-N12
13. Deutschman CS: Acute-phase responses and SIRS/MODS: The good, the bad, and the nebulous. Crit Care Med 1998; 26:1630-1631
14. Read RC: Experimental therapies for sepsis directed against tumour necrosis factor. J Antimicrob Chemother 1998; 41(Suppl A): 65-69
15. Baumgartner JD, Calandra T: Treatment of sepsis: Past and future avenues. Drugs 1999; 57:127-132
16. Huber TS, Gaines GC, Welborn MB III, et al: Anticytokine therapies for acute inflammation and the systemic inflammatory response syndrome: IL-10 and ischemia/reperfusion injury as a new paradigm. Shock 2000; 13:425-434
17. Reinhart K, Karzai W: Anti-tumor necrosis factor therapy in sepsis: Update on clinical trials and lessons learned. Crit Care Med 2001; 29:S121-S125
18. Weighardt H, Heidecke CD, Emmanuilidis K, et al: Sepsis after major visceral surgery is associated with sustained and interferon-gamma-resistant defects of monocyte cytokine production. Surgery 2000; 127:309-315
19. Hensler T, Hecker H, Heeg K, et al: Distinct mechanisms of immunosuppression as a consequence of major surgery. Infect Immun 1997; 65:2283-2291
20. Brune IB, Wilke W, Hensler T, et al: Downregulation of T helper type 1 immune response and altered pro- inflammatory and anti-inflammatory T cell cytokine balance following conventional but not laparoscopic surgery. Am J Surg 1999; 177:55-60
21. Ferguson NR, Galley HF, Webster NR: T helper cell subset ratios in patients with severe sepsis. Intensive Care Med 1999; 25:106-109
22. Heidecke CD, Hensler T, Weighardt H, et al: Selective defects of T lymphocyte function in patients with lethal intraabdominal infection. Am J Surg 1999; 178:288-292
23. Wick M, Kollig E, Walz M, et al: Does liberation of interleukin-12 correlate with the clinical course of polytraumatized patients? Chirurg 2000; 71:1126-1131
24. de Metz J, Hack CE, Romijn JA, et al: Interferon-gamma in healthy subjects: Selective modulation of inflammatory mediators. Eur J Clin Invest 2001; 31:536-543
25. Marie C, Fitting C, Muret J, et al: Interleukin 8 production in whole blood assays: Is interleukin 10 responsible for the downregulation observed in sepsis? Cytokine 2000; 12:55-61
26. Muret J, Marie C, Fitting C, et al: Ex vivo T-lymphocyte derived cytokine production in SIRS patients is influenced by experimental procedures. Shock 2000; 13:169-174
27. Kapsenberg ML, Kalinski P: The concept of type 1 and type 2 antigen-presenting cells. Immunol Lett 1999; 69:5-6
28. de Jong EC, Vieira PL, Kalinski P, et al: Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals. J Immunol 2002; 168:1704-1709
29. Kasper ML, Miller WJ, Jacob HS: G6PD-deficiency infectious haemolysis: A complement dependent innocent bystander phenomenon. Br J Haematol 1986; 63:85-91
30. Spolarics Z, Siddiqi M, Siegel JH, et al: Increased incidence of sepsis and altered monocyte functions in severely injured type A- glucose-6-phosphate dehydrogenase-deficient African American trauma patients. Crit Care Med 2001; 29:728-736
31. Baker SP, O'Neill B, Haddon WJ, et al: The injury severity score: A method for describing patients with multiple injuries and evaluating emergency care. J Trauma 1974; 14:187-196
32. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine [see comments]. Chest 1992; 101:1644-1655
33. Bernard GR, Artigas A, Brigham KL, et al: The American-European Consensus Conference on ARDS: Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994; 149:818-824
34. Jung T, Schauer U, Heusser C, et al: Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993; 159:197-207
35. Abbott KC, Agodoa LY: Etiology of bacterial septicemia in chronic dialysis patients in the United States. Clin Nephrol 2001; 56:124-131
36. Schroder J, Kahlke V, Book M, et al: Gender differences in sepsis: Genetically determined? Shock 2000; 14:307-310
37. Diodato MD, Knoferl MW, Schwacha MG, et al: Gender differences in the inflammatory response and survival following haemorrhage and subsequent sepsis. Cytokine 2001; 14:162-169
38. Siddiqi M, Garcia ZC, Stein DS, et al: Relationship between oxidative burst activity and CD11b expression in neutrophils and monocytes from healthy individuals: Effects of race and gender. Cytometry 2001; 46:243-246
39. Heidecke CD, Weighardt H, Hensler T, et al: Immune paraysis of T-lymphocytes and monocytes in postoperative abdominal sepsis: Correlation of immune function with survival. Chirurg 2000; 71:159-165
40. Weighardt H, Heidecke CD, Westerholt A, et al: Impaired monocyte IL-12 production before surgery as a predictive factor for the lethal outcome of postoperative sepsis. Ann Surg 2002; 235:560-567
41. Goebel A, Kavanagh E, Lyons A, et al: Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection. Ann Surg 2000; 231:253-261
42. Jason J, Archibald LK, Nwanyanwu OC, et al: Cytokines and malaria parasitemia. Clin Immunol 2001; 100:208-218
43. O'Suilleabhain C, O'Sullivan ST, Kelly JL, et al: Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury. Surgery 1996; 120:290-296
44. Schinkel C, Licht K, Zedler S, et al: Perioperative treatment with human recombinant interferon-gamma: A randomized double-blind clinical trial. Shock 2001; 16:329-333
45. Hilkens CM, Snijders A, Snijdewint FG, et al: Modulation of T-cell cytokine secretion by accessory cell-derived products. Eur Respir J Suppl 1996; 22:90S-94S.
46. Kalinski P, Vieira PL, Schuitemaker JH, et al: Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL- 12p40) production and an inhibitor of bioactive IL-12p70 heterodimer. Blood 2001; 97:3466-3469
47. Dobashi K, Aihara M, Araki T, et al: Regulation of LPS induced IL-12 production by IFN-gamma and IL-4 through intracellular glutathione status in human alveolar macrophages. Clin Exp Immunol 2001; 124:290-296
48. Endo S, Inada K, Kasai T, et al: Soluble CD14 (sCD14) levels in patients with multiple organ failure (MOF). Res Commun Chem Pathol Pharmacol 1994; 84:17-25
49. Carrillo EH, Gordon L, Goode E, et al: Early elevation of soluble CD14 may help identify trauma patients at high risk for infection. J Trauma 2001; 50:810-816