Design and synthesis of 4-(α-hydroxymalonyl)phenylalanine as a new phosphotyrosyl mimetic and its use in growth factor receptor bound 2 Src-homology 2 (Grb2 SH2) domain-binding peptides

Journal of Medicinal Chemistry

Volumn 48, Issue 16, 2005, Pages 5369-5372

  Kang, Sang Uk ^a   Worthy, Karen M ^b   Bindu, Lakshman K ^b   Zhang, Manchao ^c   Yang, Dajun ^c   Fisher, Robert J ^b   Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (ALPHA HYDROXYMALONYL)PHENYLALANINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTER DERIVATIVE; GROWTH FACTOR RECEPTOR; PHENYLALANINE DERIVATIVE; PRODRUG; PROTEIN TYROSINE PHOSPHATASE; SIGNALING LYMPHOCYTE ACTIVATION MOLECULE ASSOCIATED PROTEIN; TRIPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BROMINATION; DECARBOXYLATION; DERIVATIZATION; DRUG DESIGN; DRUG EFFICACY; DRUG SYNTHESIS; ESTERIFICATION; HYDROXYLATION; NONHUMAN; PROTEIN DOMAIN; RECEPTOR AFFINITY; RECEPTOR BINDING; SRC HOMOLOGY DOMAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE, TUMOR; DRUG DESIGN; ESTERS; GRB2 ADAPTOR PROTEIN; HUMANS; MALONATES; OLIGOPEPTIDES; PHENYLALANINE; PHOSPHOTYROSINE; PRODRUGS; RECEPTOR, ERBB-2; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 23444433256     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050154v     Document Type: Article

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