Expression of cyclins A, E and topoisomerase II α correlates with centrosome amplification and genomic instability and influences the reliability of cytometric S-phase determination

BMC Cell Biology

Volumn 4, Issue , 2003, Pages

  Kronenwett, Ulrike ^a   Castro, Juan ^a   Roblick, Uwe J ^b   Fujioka, Kaoru ^a   Östring, Carin ^a   Faridmoghaddam, Farinaz ^a   Laytragoon Lewin, Nongnit ^a   Tribukait, Bernhard ^a   Auer, Gert ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CYCLIN A; CYCLIN E; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE (ATP HYDROLYSING) ALPHA; MESSENGER RNA; UNCLASSIFIED DRUG;

ANEUPLOIDY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CENTROSOME; CONTROLLED STUDY; CORRELATION ANALYSIS; DIPLOIDY; DNA CONTENT; DNA REPLICATION; FLOW CYTOMETRY; GENE AMPLIFICATION; GENE REPLICATION; GENETIC STABILITY; HISTOGRAM; HUMAN; HUMAN CELL; MITOSIS; PROTEIN EXPRESSION; RELIABILITY;

ANTIGENS, NEOPLASM; BROMODEOXYURIDINE; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; CENTROSOME; CYCLIN A; CYCLIN E; DNA; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; G1 PHASE; GENE EXPRESSION; GENOMIC INSTABILITY; HUMANS; MICROSCOPY, FLUORESCENCE; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; S PHASE;

MINK CELL FOCUS-FORMING VIRUS;

EID: 2342663136     PISSN: 14712121     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2121-4-8     Document Type: Article

References (43)

1. Paintrand M, Moudjou M, Delacroix H and Bornens M: Centrosome organization and centriole architecture: their sensitivity to divalent cations J Struct Biol 1992, 108(2):107-128.
2. Kellogg DR, Moritz M and Alberts BM: The centrosome and cellular organization Annu Rev Biochem 1994, 63:639-674.
3. Meraldi P, Lukas J, Fry AM, Bartek J and Nigg EA: Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A Nat Cell Biol 1999, 1(2):88-93.
4. Sluder G and Hinchcliffe EH: The apparent linkage between centriole replication and the S phase of the cell cycle Cell Biol Int 1998, 22(1):3-5.
5. Hinchcliffe EH, Li C, Thompson EA, Maller JL and Sluder G: Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts Science 1999, 283(5403):851-854.
6. Wimmel A, Lucibello FC, Sewing A, Adolph S and Muller R: Inducible acceleration of G1 progression through tetracycline-regulated expression of human cyclin E Oncogene 1994, 9(3):995-997.
7. Morgan DO: Cyclin-dependent kinases: engines, clocks, and microprocessors Annu Rev Cell Dev Biol 1997, 13:261-291.
8. Reed SI: Control of the G1/S transition Cancer Surv 1997, 29:7-23.
9. Geley S, Kramer E, Gieffers C, Gannon J, Peters JM and Hunt T: Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint J Cell Biol 2001, 153(1):137-148.
10. Girard F, Strausfeld U, Fernandez A and Lamb NJ: Cyclin A is required for the onset of DNA replication in mammalian fibroblasts Cell 1991, 67(6):1169-1179.
11. Pagano M, Pepperkok R, Verde F, Ansorge W and Draetta G: Cyclin A is required at two points in the human cell cycle Embo J 1992, 11(3):961-971.
12. Lacey KR, Jackson PK and Stearns T: Cyclin-dependent kinase control of centrosome duplication Proc Natl Acad Sci U S A 1999, 96(6):2817-2822.
13. Keyomarsi K and Pardee AB: Redundant cyclin overexpression and gene amplification in breast cancer cells Proc Natl Acad Sci U S A 1993, 90(3):1112-1116.
14. Nielsen NH, Arnerlov C, Emdin SO and Landberg G: Cyclin E over-expression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status Br J Cancer 1996, 74(6):874-880.
15. Lynch BJ, Guinee DG Jr and Holden JA: Human DNA topoisomerase II-alpha: a new marker of cell proliferation in invasive breast cancer Hum Pathol 1997, 28(10):1180-1188.
16. Woessner RD, Mattern MR, Mirabelli CK, Johnson RK and Drake FH: Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells Cell Growth Differ 1991, 2(4):209-214.
17. Osheroff N, Zechiedrich EL and Gale KC: Catalytic function of DNA topoisomerase II Bioessays 1991, 13(6):269-273.
18. Wang JC: DNA topoisomerases Annu Rev Biochem 1985, 54:665-697.
19. Goswami PC, Roti Roti JL and Hunt CR: The cell cycle-coupled expression of topoisomerase IIalpha during S phase is regulated by mRNA stability and is disrupted by heat shock or ionizing radiation Mol Cell Biol 1996, 16(4):1500-1508.
20. Brinkley BR and Goepfert TM: Supernumerary centrosomes and cancer: Boveri's hypothesis resurrected Cell Motil Cytoskeleton 1998, 41(4):281-288.
21. Orr-Weaver TL and Weinberg RA: A checkpoint on the road to cancer Nature 1998, 392(6673):223-224.
22. Levine DS, Sanchez CA, Rabinovitch PS and Reid BJ: Formation of the tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastasesimian virus 40 tumor antigen transgenic mouse model of pancreatic cancer Proc Natl Acad Sci U S A 1991, 88(15):6427-6431.
23. Lingle WL, Lutz WH, Ingle JN, Maihle NJ and Salisbury JL: Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity Proc Natl Acad Sci U S A 1998, 95(6):2950-2955.
24. Collecchi P, Santoni T, Gnesi E, Giuseppe Naccarato A, Passoni A, Rocchetta M, Danesi R and Bevilacqua G: Cyclins of phases G1, S and G2/M are overexpressed in aneuploid mammary carcinomas Cytometry 2000, 42(4):254-260.
25. Stanta G, Bonin S, Losi L and Eusebi V: Molecular characterization of intraductal breast carcinomas Virchows Arch 1998, 432(2):107-111.
26. Fukasawa K, Choi T, Kuriyama R, Rulong S and Vande Woude GF: Abnormal centrosome amplification in the absence of p53 Science 1996, 271(5256):1744-1747.
27. Tarapore P, Horn HF, Tokuyama Y and Fukasawa K: Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway Oncogene 2001, 20(25):3173-3184.
28. Xu J and Loo G: Different effects of genistein on molecular markers related to apoptosis in two phenotypically dissimilar breast cancer cell lines J Cell Biochem 2001, 82(1):78-88.
29. Niculescu AB 3rd, Chen X, Smeets M, Hengst L, Prives C and Reed SI: Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication Mol Cell Biol 1998, 18(1):629-643.
30. Stewart ZA, Leach SD and Pietenpol JA: p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption Mol Cell Biol 1999, 19(1):205-215.
31. Hinchcliffe EH and Sluder G: "It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle Genes Dev 2001, 15(10):1167-1181.
32. Meraldi P and Nigg EA: Centrosome cohesion is regulated by a balance of kinase and phosphatase activities J Cell Sci 2001, 114(Pt 20):3749-3757.
33. Castro J, Heiden T, Wang N and Tribukait B: Preparation of cell nuclei from fresh tissues for high-quality DNA flow cytometry Cytometry 1993, 14(7):793-804.
34. Orlando C, Pinzani P and Pazzagli M: Developments in quantitative PCR Clin Chem Lab Med 1998, 36(5):255-269.
35. Gibson UE, Heid CA and Williams PM: A novel method for real time quantitative RT-PCR Genome Res 1996, 6(10):995-1001.
36. Heid CA, Stevens J, Livak KJ and Williams PM: Real time quantitative PCR Genome Res 1996, 6(10):986-994.
37. Holland PM, Abramson RD, Watson R and Gelfand DH: Detection of specific polymerase chain reaction product by utilizing the 5′----3′ exonuclease activity of Thermus aquaticus DNA polymerase Proc Natl Acad Sci U S A 1991, 88(16):7276-7280.
38. Lee LG, Connell CR and Bloch W: Allelic discrimination by nick-translation PCR with fluorogenic probes Nucleic Acids Res 1993, 21(16):3761-3766.
39. Higuchi R, Fockler C, Dollinger G and Watson R: Kinetic PCR analysis: real-time monitoring of DNA amplification reactions Biotechnology (N Y) 1993, 11(9):1026-1030.
40. User Bulletin #2. ABI PRISM Sequence Detection System 1997 [http://www.ukl.uni-freiburg.de/core-facility/taqman/user_bulletin_2.pdf]
41. Auer GU, Caspersson TO and Wallgren AS: DNA content and survival in mammary carcinoma Anal Quant Cytol 1980, 2(3):161-165.
42. Sangfelt O, Erickson S, Castro J, Heiden T, Gustafsson A, Einhorn S and Grander D: Molecular mechanisms underlying interferonalpha-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins Oncogene 1999, 18(18):2798-2810.
43. Gong J, Traganos F and Darzynkiewicz Z: Growth imbalance and altered expression of cyclins B1, A, E, and D3 in MOLT-4 cells synchronized in the cell cycle by inhibitors of DNA replication Cell Growth Differ 1995, 6(11):1485-1493.