Inhibitory effect of cyclosporin A on p-glycoprotein function in peripheral nerves of mice treated with doxorubicin and vinblastine

Acta Oto-Laryngologica

Volumn 124, Issue 3, 2004, Pages 313-317

  Saito, Takehisa ^a   Zhang, Zhi Jian ^a   Ohtsubo, Toshio ^a   Noda, Ichiro ^a   Tokuriki, Masaharu ^a   Shibamori, Yoshiyuki ^a   Yamamoto, Takehito ^a   Saito, Hitoshi ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

Blood nerve barrier; Drug extrusion pump; Mdr1a(+ +) mice; Mdr1a( ) mice; Neurotoxic drugs; Pharmacokinetics; Sciatic nerve; VIIIth nerve; VIIth nerve

Indexed keywords

CYCLOSPORIN A; DOXORUBICIN; GLYCOPROTEIN P; NEUROTOXIN; VINBLASTINE SULFATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG TISSUE LEVEL; FACIAL NERVE; MALE; MOUSE; NEWBORN; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN FUNCTION; SCIATIC NERVE; TISSUE DISTRIBUTION; VESTIBULOCOCHLEAR NERVE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ATP-BINDING CASSETTE TRANSPORTERS; CYCLOSPORINE; DOXORUBICIN; DRUG INTERACTIONS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; NEUROTOXINS; P-GLYCOPROTEIN; P-GLYCOPROTEINS; PERIPHERAL NERVES; TISSUE DISTRIBUTION; VINBLASTINE;

EID: 2342641490     PISSN: 00016489     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016480310005093     Document Type: Article

References (15)

1. Rechthand E, Rapaport SI. Regulation of the microenvironment of peripheral nerve: role of the blood-nerve barrier. Prog Neurobiol 1987; 28: 303-43.
2. Schinkel AH, Smit JJM, van Tellingen O, et al. Disruption of the mouse mdr1a p-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994; 77: 491-502.
3. Saito T, Zhang Z-J, Shibamori Y, et al. P-glycoprotein expression in capillary endothelial cells of the 7th and 8th nerves of guinea pig in relation to blood-nerve barrier sites. Neurosci Lett 1997; 232: 41-4.
4. Saito T, Zhang Z-J, Ohtsubo T, et al. Homozygous disruption of the mdr1a p-glycoprotein gene affects blood-nerve barrier in mice administered with neurotoxic drugs. Acta Otolaryngol 2001; 121: 735-42.
5. Colombo T, Zucchetti M, D'Incalci M. Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats. J Pharmacol Exp Ther 1994; 269: 22-7.
6. Lyubimov E, Lan L-B, Pashinsky I, Stein WD. Effect of modulators of the multidrug resistance pump on the distribution of vinblastine in tissues of the mouse. Anticancer Drugs 1996; 7: 60-9.
7. Arboix M, Paz OG, Colombo T, D'Incalci M. Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis. J Pharmacol Exp Ther 1997; 281: 1226-30.
8. Bellamy WT, Peng YM, Odeleye A, et al. Cardiotoxicity in the SCID mouse following administration of doxorubicin and cyclosporin A. Anticancer Drugs 1995; 6: 736-43.
9. Saito T, Zhang Z-J, Tokuriki M, et al. Expression of p-glycoprotein is associated with that of multidrug resistance protein 1 (MRP1) in the vestibular labyrinth and endolymphatic sac of the guinea pig. Neurosci Lett 2001; 303: 189-92.
10. Saito T, Zhang Z-J, Tokuriki M, et al. Expression of multidrug resistance protein 1 (MRP1) in the rat cochlea with special reference to the blood-inner ear barrier. Brain Res 2001; 895: 253-7.
11. Zhang Z-J, Saito T, Kimura Y, Sugimoto C, Ohtsubo T, Saito H. Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood-inner ear barrier in mice. Brain Res 2000; 852: 116-26.
12. Saito T, Zhang Z-J, Tokuriki M, et al. Cyclosporin A inhibits the extrusion pump function of p-glycoprotein in the inner ear of mice treated with vinblastine and doxorubicin. Brain Res 2001; 901: 265-70.
13. Saito T, Zhang Z-J, Tokuriki M, et al. Doxorubucin ototoxicity is induced in mice by combination treatment with cyclosporin A. Acta Otolaryngol 2001; 121: 787-93.
14. Barbui T, Rambaldi A, Parenzan L, Zucchelli M, Perico N, Remuzzi G. Neurological symptoms and coma associated with doxorubicin administration during chronic cyclosporin therapy. Lancet 1992; 339: 1421.
15. Bertrand Y, Capdeville R, Balduck N, Philippe N. Cyclosporin A used to reverse drug resistance increases vincristine neurotoxicity. Am J Hematol 1992; 40: 158-9.