Doxorubicin ototoxicity is induced in mice by combination treatment with cyclosporin A

Acta Oto-Laryngologica

Volumn 121, Issue 7, 2001, Pages 787-793

  Saito, T ^a   Zhang, Z J ^a   Tokuriki, M ^a   Shibamori, Y ^a   Yamamoto, T ^a   Noda, I ^a   Ohtsubo, T ^a   Saito, H ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

Auditory brainstem response; Cyclosporin A; Doxorubicin; Inner ear; Ototoxicity

Indexed keywords

CYCLOSPORIN A; DOXORUBICIN; GLYCOPROTEIN P;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY NERVOUS SYSTEM; BRAIN STEM RESPONSE; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG MECHANISM; DRUG TISSUE LEVEL; DRUG TRANSPORT; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; INNER EAR; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS; AUDITORY THRESHOLD; BLOOD-BRAIN BARRIER; CYCLOSPORINE; DOXORUBICIN; EAR, INNER; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HEARING DISORDERS; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; P-GLYCOPROTEIN;

EID: 0035160896     PISSN: 00016489     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016480152602212     Document Type: Article

References (25)

1. Biochemistry of multidrug resistance mediated by the multidrug transporter
2. Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells
3. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities
4. Expression of a multidrug-resistance gene in human tumors and tissues
5. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissuses
6. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
7. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
8. Labyrinthine barriers and cochlear homeostasis
9. Transport characteristics of the blood-perilymph barrier
10. Nature of blood-labyrinth barrier in experimental conditions
11. The blood-perilymph barrier
12. Expression of p-glycoprotein in inner ear capillary endothelial cells of the guinea pig with special reference to blood-inner ear barrier
13. Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood-inner ear barrier in mice
14. A new anticancer drug with significant clinical activity
15. Modulation of multidrug-resistant multiple myeloma by cyclosporin
16. Cardiotoxicity in the SCID mouse following administration of doxorubicin and cyclosporin A
17. Multidrug resistance transporters and modulation
18. Neurological symptoms and coma associated with doxorubicin administration during chronic cyclosporin therapy
19. Increased neurotoxicity with VAD-cyclosporin in multiple myeloma
20. Kinetic experiments with radionuclides concerning the perilymph-blood barrier in a guinea pig model
21. Fine structure and permeability of capillaries in the stria vascularis and spiral ligament of the inner ear of the guinea pig
22. Same location of the source of P1 of BAEPs and N1 of CAP in guinea pig
23. Mechanisms of central conduction time prolongation in brain-stem auditory evoked potentials
24. Cytotoxic effects of adriamycin on the central nervous system of the mouse - Cytofluorescence and electron-microscopic observations after various modes of administration
25. Changes in the electrochemical composition of cochlear fluids after intracisternal application of doxorubicin in the rat