Cyclosporin A inhibits the extrusion pump function of p-glycoprotein in the inner ear of mice treated with vinblastine and doxorubicin

Brain Research

Volumn 901, Issue 1-2, 2001, Pages 265-270

  Saito, Takehisa ^a   Zhang, Zhi Jian ^a   Tokuriki, Masaharu ^a   Ohtsubo, Toshio ^a   Shibamori, Yoshiyuki ^a   Yamamoto, Takehito ^a   Saito, Hitoshi ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

Blood inner ear barrier; Cyclosporin A; Doxorubicin; p Glycoprotein; Pharmacokinetics; Vinblastine

Indexed keywords

CYCLOSPORIN A; DOXORUBICIN; GLYCOPROTEIN P; VINBLASTINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; CANCER; CANCER CHEMOTHERAPY; DRUG EFFECT; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; BRAIN; CELL MEMBRANE; CYCLOSPORINE; DOXORUBICIN; DRUG INTERACTIONS; DRUG RESISTANCE, MULTIPLE; EAR, INNER; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; MICE, KNOCKOUT; P-GLYCOPROTEIN; VINBLASTINE; VISCERA;

EID: 0035906533     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02321-6     Document Type: Article

References (20)

1. Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the p-glycoprotein but do not enhance drug penetration in brain and testis
2. Neurological symptoms and coma associated with doxorubicin administration during chronic cyclosporin therapy
3. Modulators of p-glycoprotein-associated multidrug resistance
4. Neurological symptoms associated with cyclosporin plus doxorubicin
5. Cardiotoxicity in the SCID mouse following administration of doxorubicin and cyclosporin A
6. Cytotoxic effects of adriamycin on the central nervous system of the mouse - Cytofluorescence and electron-microscopic observations after various modes of administration
7. A family of drug transporters: The multidrug resistance-associated proteins
8. Block of axoplasmic transport in vitro by vinca alkaloids
9. Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats
10. The biochemistry of p-glycoprotein-mediated multidrug resistance
11. Effect of modulators of the multidrug resistance pump on the distribution of vinblastine in tissues of the mouse
12. Expression of multidrug resistance protein 1 (MRP1) in the rat cochlea with special reference to the blood-inner ear barrier
13. Disruption of the mouse mdr1a p-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
14. The effect of vincristine on the neurological elements of the rabbit cochlea
15. The effect of vinblastine sulphate on the neurological elements of the rabbit cochlea
16. Changes in the electrochemical composition of cochlear fluids after intracisternal application of doxorubicin in the rat
17. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
18. Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a p-glycoprotein
19. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
20. Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood-inner ear barrier in mice