Imaging serotonin transporters with i-adam brain spect in healthy non-human primates

Nuclear Medicine Communications

Volumn 25, Issue 5, 2004, Pages 515-519

  Huang, Wen Sheng ^a   Ma, Kuo Hsing ^a   Cheng, Cheng Yi ^b   Chen, Cheng Yu ^b   Fu, Ying Kai ^c   Chou, Yuan Hwa ^c   Wey, Shiaw Pyng ^d   Liu, Jian Chuan ^d  

^a Tri Service General Hospital   (United States)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c Nuclear Fuels and Materials Division Institute of Nuclear Energy Research   (United States)

^d National Defense Medical Center   (United States)

Author keywords

Brain SPECT; I ADAM; Non human primate; Serotonin transporter

Indexed keywords

2 [[2 [(DIMETHYLAMINO)METHYL]PHENOXY]THIO] 5 IODOPHENYLAMINE I 123; SEROTONIN TRANSPORTER; TRACER; UNCLASSIFIED DRUG;

ARTICLE; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; FRONTAL CORTEX; IMAGE ANALYSIS; MACACA; MESENCEPHALON; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIMATE; RADIOACTIVITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TEMPORAL CORTEX; THALAMUS; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; CINANSERIN; FEMALE; HUMANS; IODINE RADIOISOTOPES; MACACA; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; METABOLIC CLEARANCE RATE; NERVE TISSUE PROTEINS; PRIMATES; RADIOPHARMACEUTICALS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TISSUE DISTRIBUTION;

EID: 2342590028     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/00006231-200405000-00014     Document Type: Article

References (17)

1. Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 1994; 40:288-295.
2. Joyce JN, Shane A, Lexow N, Winokur A, Casanova MF, Kleinman JE. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 1993; 8:315-336.
3. Helfenbein J, Sandell J, Halldin C, Chalon S, Emond P, Obuko Y, et al. PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter. Nucl Med Biol 1999; 26:491-499.
4. Oya S, Choi SR, Hou C, Mu M, Kung MP, Acton PD, et al. 2-((2-((dimethylamino)methyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nucl Med Biol 2000; 27:249-254.
5. Pike VW. Radioligand for PET studies of central 5-HT receptors and re-uptake sites - current status. Nucl Med Biol 1995; 22:1011-1018.
6. 11C]AFM. J Cereb Blood Flow Metab 2002; 22:1377-1398.
7. Staley JK, Malison RT, Innis RB. Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression. Biol Psychiat 1998; 44:534-549.
8. Mann JJ. The role of in vivo neurotransmitter system imaging studies in understanding major depression. Biol Psychiat 1998; 44:1077-1078.
9. 123I]IDAM: 5-iodo-2-[[2-2[dimethylamino]methyl]phenyl]thio]benzyl alcohol. J Med Chem 1999; 42:333-335.
10. Zhuang ZP, Choi SR, Hou C, Mu M, Kung MP, Acton PD, Kung HF. A novel serotonin transporter ligand: 5-iodo-2-(2-dimethylaminomethylphenoxyl)-benzyl alcohol (ODAM). Nucl Med Biol 2000; 27:169-175.
11. Acton PD, Mu M, Hou C, Siciliano M, Lupo J, Oya S, et al. Comparison of three selective serotonin transporter radioligands for SPECT [Abstract]. J Nucl Med 2000; 41(suppl):39P.
12. 125I]ADAM and SPECT. J Nucl Med 2001; 42:1556-1562.
13. Ahonen AK, Kauppinen TA, Heikman P, Bergaström KA, Launes J, Nikkinen P, Hiltunen J. I-123 labeled ADAM - a selective novel radioligand for imaging of serotonin transporters in the human brain. J Nucl Med 2002; 43:232P.
14. 123I]ADAM in healthy human subjects: preliminary results. Eur J Nucl Med 2003; 30:132-136.
15. 125I]ADAM to serotonin transporters in rat brain. Synapse 2000; 38:403-412.
16. 3H]imipramine in human brain. J Neurochem 1981; 37:267-271.
17. 3H]paroxetine. Neuroscience 1988; 27:473-496.