Phosphatases as small-molecule targets: Inhibiting the endogenous inhibitors of kinases

Biochemical Society Transactions

Volumn 32, Issue 2, 2004, Pages 348-349

  Schmid, A C ^a   Woscholski, R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Inhibitor; Phosphatase; Phosphoinositide 3 kinase; Protein kinase B Akt; PTEN (phosphatase and tensin homologue deleted on chromosome 10); Small molecule

Indexed keywords

2 OXALYLAMINOBENZOIC ACID; CALYCULIN A; CANTHARIDIN; CYCLOSPORIN A; DEPHOSTATIN; INOSITOL; INOSITOL DERIVATIVE; L 690330; L 690488; LITHIUM; OKADAIC ACID; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOTRANSFERASE INHIBITOR; TAUTOMYCIN; UNCLASSIFIED DRUG;

ACCURACY; BINDING AFFINITY; CELL FUNCTION; COMPETITIVE INHIBITION; CONFERENCE PAPER; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME INHIBITION; INHIBITION KINETICS; MOLECULAR SIZE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ENZYME INHIBITORS; HUMANS; MODELS, BIOLOGICAL; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEINS;

EID: 2342472006     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0320348     Document Type: Conference Paper

References (30)

1. 349 1 Stephens, L.R., Hughes, K.T. and Irvine, R.F. (1991) Nature (London) 351, 33-39
2. Wang, X., Gjorloff-Wingren, A., Saxena, M., Pathan, N., Reed, J.C. and Mustelin, T. (2000) J. Immunol. 164, 1934-1939
3. Besson, A., Robbins, S.M. and Yong, V.W. (1999) Eur. J. Biochem. 263, 605-611
4. Stocker, H., Andjelkovic, M., Oldham, S., Laffargue, M., Wymann, M.P., Hemmings, B.A. and Hafen, E. (2002) Science 295, 2088-2091
5. Woscholski, R., Kodaki, T., McKinnon, M., Waterfield, M.D. and Parker, P.J. (1994) FEBS Lett. 342, 109-114
6. Vlahos, C.J., Matter, W.F., Hui, K.Y. and Brown, R.F. (1994) J. Biol. Chem. 269, 5241-5248
7. Brunn, G.J., Williams, J., Sabers, C., Wiederrecht, G., Lawrence, Jr, J.C. and Abraham, R.T. (1996) EMBO J. 15, 5256-5267
8. Banin, S., Moyal, L., Shieh, S., Taya, Y., Anderson, C.W., Chessa, L., Smorodinsky, N.I., Prives, C., Reiss, Y., Shiloh, Y. and Ziv, Y. (1998) Science 281, 1674-1677
9. Izzard, R.A., Jackson, S.P. and Smith, G.C. (1999) Cancer Res. 59, 2581-2586
10. Okkenhaug, K., Bilancio, A., Farjot, G., Priddle, H., Sancho, S., Peskett, E., Pearce, W., Meek, S.E., Salpekar, A., Waterfield, M.D. et al. (2002) Science 297, 1031-1034
11. Zhang, Z.Y. (2002) Annu. Rev. Pharmacol. Toxicol. 42, 209-234
12. Zhang, Z.Y., Zhou, B. and Xie, L. (2002) Pharmacol. Ther. 93, 307-317
13. Wang, W.Q., Sun, J.P. and Zhang, Z.Y. (2003) Curr. Top. Med. Chem. 3, 739-748
14. Seargeant, L.E. and Stinson, R.A. (1979) Biochem. J. 181, 247-250
15. Ishihara, H., Martin, B.L., Brautigan, D.L., Karaki, H., Ozaki, H., Kato, Y., Fusetani, N., Watabe, S., Hashimoto, K., Uemura, D. et al. (1989) Biochem. Biophys. Res. Commun. 159, 871-877
16. Groblewski, G.E., Wagner, A.C. and Williams, J.A. (1994) J. Biol. Chem. 269, 15111-15117
17. Leech, A.P., Baker, G.R., Shute, J.K., Cohen, M.A. and Gani, D. (1993) Eur. J. Biochem. 212, 693-704
18. Atack, J.R., Prior, A.M., Fletcher, S.R., Quirk, K., McKernan, R. and Ragan, C.J. (1994) J. Pharmacol. Exp. Ther. 270, 70-76
19. Atack, J.R., Cook, S.M., Watt, A.P., Fletcher, S.R. and Ragan, C.I. (1993) J. Neurochem. 60, 652-658
20. Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K., Timms, J., Katso, R., Oriscoll, P.C., Woscholski, R., Parker, P.J. and Waterfield, M.O. (2001) Annu. Rev. Biochem. 70, 535-602
21. Zolnierowicz, S. (2000) Biochem. Pharmacol. 60, 1225-1235
22. Honkanen, R.E. (1993) FEBS Lett. 330, 283-286
23. Cohen, P., Klumpp, S. and Schelling, D.L. (1989) FEBS Lett. 250, 596-600
24. Mitsuhashi, S., Matsuura, N., Ubukata, M., Oikawa, H., Shima, H. and Kikuchi, K. (2001) Biochem. Biophys. Res. Commun. 287, 328-331
25. MacKintosh, C. and Klumpp, S. (1990) FEBS Lett. 277, 137-140
26. Hemenway, C.S. and Heitman, J. (1999) Cell. Biochem. Biophys. 30, 115-151
27. Imoto, M., Kakeya, H., Sawa, T., Hayashi, C., Hamada, M., Takeuchi, T. and Umezawa, K. (1993) J. Antibiot. (Tokyo) 46, 1342-1346
28. Iversen, L.F., Andersen, H.S., Branner, S., Mortensen, S.B., Peters, G.H., Morris, K., Olsen, O.H., Jeppesen, C.B., Lundt, B.F., Ripka, W. et al. (2000) J. Biol. Chem. 275, 10300-10307
29. Fauroux, C.M. and Freeman, S. (1999) J. Enzyme inhib. 14, 97-108
30. Busa, W.B. and Gimlich, R.L. (1989) Dev. Biol. 132, 315-324