COX-2 inhibition results in alterations in nuclear factor (NF)-κB activation but not cytokine production in acute pancreatitis

Journal of Gastrointestinal Surgery

Volumn 8, Issue 4, 2004, Pages 511-519

  Slogoff, Michele I ^a   Ethridge, Richard T ^a   Rajaraman, Srinivasan ^a   Evers, B Mark ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

COX 2; cytokines; NF B; Pancreatitis

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; CERULETIDE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; PROTEIN SUBUNIT; SODIUM CHLORIDE;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; INFLAMMATION; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; TISSUE SECTION;

ACUTE DISEASE; ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; FEMALE; INTERLEUKIN-1; INTERLEUKIN-6; ISOENZYMES; MICE; NF-KAPPA B; PANCREATITIS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES;

EID: 2342440644     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gassur.2003.11.023     Document Type: Article

References (56)

1. Wilson P.G., Manji M., Neoptolemos J.P. Acute pancreatitis as a model of sepsis. J Antimicrob Chemother. 41:(Suppl A):1998;51-63
2. Winslet M., Hall C., London N.J., Neoptolemos J.P. Relation of diagnostic serum amylase levels to aetiology and severity of acute pancreatitis. Gut. 33:1992;982-986
3. Neoptolemos J.P., Raraty M., Finch M., Sutton R. Acute pancreatitis: the substantial human and financial costs. Gut. 42:1998;886-891
4. Baron T.H., Morgan D.E. Acute necrotizing pancreatitis. N Engl J Med. 340:1999;1412-1417
5. Ho H.S., Frey C.F. Gastrointestinal and pancreatic complications associated with severe pancreatitis. Arch Surg. 130:1995;817-822. discussion 822-823
6. Beger H.G., Rau B., Mayer J., Pralle U. Natural course of acute pancreatitis. World J Surg. 21:1997;130-135
7. Formela L.J., Galloway S.W., Kingsnorth A.N. Inflammatory mediators in acute pancreatitis. Br J Surg. 82:1995;6-13
8. Gross V., Andreesen R., Leser H.G., Ceska M., Liehl E., Lausen M., Farthmann E.H., Scholmerich J. Interleukin-8 and neutrophil activation in acute pancreatitis. Eur J Clin Invest. 22:1992;200-203
9. Gross V., Leser H.G., Heinisch A., Scholmerich J. Inflammatory mediators and cytokines - new aspects of the pathophysiology and assessment of severity of acute pancreatitis? Hepatogastroenterology. 40:1993;522-530
10. Heath D.I., Cruickshank A., Gudgeon M., Jehanli A., Shenkin A., Imrie C.W. Role of interleukin-6 in mediating the acute phase protein response and potential as an early means of severity assessment in acute pancreatitis. Gut. 34:1993;41-45
11. Norman J. The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg. 175:1998;76-83
12. Denham W., Yang J., Fink G., Denham D., Carter G., Ward K., Norman J. Gene targeting demonstrates additive detrimental effects of interleukin-1 and tumor necrosis factor during pancreatitis. Gastroenterology. 113:1997;1741-1746
13. Fink G.W., Norman J.G. Intrapancreatic interleukin-1β gene expression by specific leukocyte populations during acute pancreatitis. J Surg Res. 63:1996;369-373
14. Norman J., Franz M., Messina J., Riker A., Fabri P.J., Rosemurgy A.S., Gower W.R. Jr. Interleukin-1 receptor antagonist decreases severity of experimental acute pancreatitis. Surgery. 117:1995;648-655
15. Gukovsky I., Gukovskaya A.S., Blinman T.A., Zaninovic V., Pandol S.J. Early NF-κB activation is associated with hormone-induced pancreatitis. Am J Physiol. 275:1998;G1402-G1414
16. Makarov S.S., Johnston W.N., Olsen J.C., Watson J.M., Mondal K., Rinehart C., Haskill J.S. NF-κB as a target for anti-inflammatory gene therapy: suppression of inflammatory responses in monocytic and stromal cells by stable gene transfer of IκB alpha cDNA. Gene Ther. 4:1997;846-852
17. Haddad J.J. Nuclear factor (NF)-κB blockade attenuates but does not abrogate LPS-mediated interleukin (IL)-1 beta biosynthesis in alveolar epithelial cells. Biochem Biophys Res Commun. 293:2002;252-257
18. Mercurio F., Manning A.M. Multiple signals converging on NF-κB. Curr Opin Cell Biol. 11:1999;226-232
19. Baeuerle P.A., Baltimore D. NF-κB: ten years after. Cell. 87:1996;13-20
20. Thanos D., Maniatis T. NF-κB: a lesson in family values. Cell. 80:1995;529-532
21. Ethridge R.T., Hashimoto K., Chung D.H., Ehlers R.A., Rajaraman S., Evers B.M. Selective inhibition of NF-κB attenuates the severity of cerulein-induced acute pancreatitis. J Am Coll Surg. 195:2002;497-505
22. Satoh A., Shimosegawa T., Fujita M., Kimura K., Masamune A., Koizumi M., Toyota T. Inhibition of nuclear factor-κB activation improves the survival of rats with taurocholate pancreatitis. Gut. 44:1999;253-258
23. Dunn J.A., Li C., Ha T., Kao R.L., Browder W. Therapeutic modification of nuclear factor κB binding activity and tumor necrosis factor-alpha gene expression during acute biliary pancreatitis. Am Surg. 63:1997;1036-1044
24. Ethridge R.T., Chung D.H., Slogoff M., Ehlers R.A., Hellmich M.R., Rajaraman S., Saito H., Uchida T., Evers B.M. Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology. 123:2002;1311-1322
25. Song A.M., Bhagat L., Singh V.P., Van Acker G.G., Steer M.L., Saluja A.K. Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol. 283:2002;G1166-G1174
26. Yamamoto K., Arakawa T., Ueda N., Yamamoto S. Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem. 270:1995;31315-31320
27. Schmedtje J.F. Jr., Ji Y.S., Liu W.L., DuBois R.N., Runge M.S. Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells. J Biol Chem. 272:1997;601-608
28. Newton R., Kuitert L.M., Bergmann M., Adcock I.M., Barnes P.J. Evidence for involvement of NF-κB in the transcriptional control of COX-2 gene expression by IL-1β Biochem Biophys Res Commun. 237:1997;28-32
29. Ethridge R.T., Ehlers R.A., Hellmich M.R., Rajaraman S., Evers B.M. Acute pancreatitis results in induction of heat shock proteins 70 and 27 and heat shock factor-1. Pancreas. 21:2000;248-256
30. Ward J.B., Sutton R., Jenkins S.A., Petersen O.H. Progressive disruption of acinar cell calcium signaling is an early feature of cerulein-induced pancreatitis in mice. Gastroenterology. 111:1996;481-491
31. Niederau C., Niederau M., Luthen R., Strohmeyer G., Ferrell L.D., Grendell J.H. Pancreatic exocrine secretion in acute experimental pancreatitis. Gastroenterology. 99:1990;1120-1127
32. Gomez G., Townsend C.M. Jr., Green D.W., Rajaraman S., Uchida T., Greeley G.H. Jr., Soloway R.D., Thompson J.C. Protective action of luminal bile salts in necrotizing acute pancreatitis in mice. J Clin Invest. 86:1990;323-331
33. Niederau C., Niederau M., Borchard F., Ude K., Luthen R., Strohmeyer G., Ferrell L.D., Grendell J.H. Effects of antioxidants and free radical scavengers in three different models of acute pancreatitis. Pancreas. 7:1992;486-496
34. Schmidt J., Lewandrowski K., Fernandez-del Castillo C., Mandavilli U., Compton C.C., Warshaw A.L., Rattner D.W. Histopathologic correlates of serum amylase activity in acute experimental pancreatitis. Dig Dis Sci. 37:1992;1426-1433
35. Sheng H., Shao J., Kirkland S.C., Isakson P., Coffey R.J., Morrow J., Beauchamp R.D., DuBois R.N. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest. 99:1997;2254-2259
36. Steinle A.U., Weidenbach H., Wagner M., Adler G., Schmid R.M. NF-κB /Rel activation in cerulein pancreatitis. Gastroenterology. 116:1999;420-430
37. Leser H.G., Gross V., Scheibenbogen C., Heinisch A., Salm R., Lausen M., Ruckauer K., Andreesen R., Farthmann E.H., Scholmerich J. Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis. Gastroenterology. 101:1991;782-785
38. Exley A.R., Leese T., Holliday M.P., Swann R.A., Cohen J. Endotoxaemia and serum tumour necrosis factor as prognostic markers in severe acute pancreatitis. Gut. 33:1992;1126-1128
39. Viedma J.A., Perez-Mateo M., Dominguez J.E., Carballo F. Role of interleukin-6 in acute pancreatitis. Comparison with C-reactive protein and phospholipase A. Gut. 33:1992;1264-1267
40. Dinarello C.A. Biologic basis for interleukin-1 in disease. Blood. 87:1996;2095-2147
41. Lowry S.F. Cytokine mediators of immunity and inflammation. Arch Surg. 128:1993;1235-1241
42. Dinarello C.A., Gelfand J.A., Wolff S.M. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA. 269:1993;1829-1835
43. Serou M.J., DeCoster M.A., Bazan N.G. Interleukin-1 β activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression. J Neurosci Res. 58:1999;593-598
44. Guan Z., Buckman S.Y., Miller B.W., Springer L.D., Morrison A.R. Interleukin-1β-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. J Biol Chem. 273:1998;28670-28676
45. Diaz A., Chepenik K.P., Korn J.H., Reginato A.M., Jimenez S.A. Differential regulation of cyclooxygenases 1 and 2 by interleukin-1β, tumor necrosis factor-α, and transforming growth factor-β 1 in human lung fibroblasts. Exp Cell Res. 241:1998;222-229
46. Powell J.J., Fearon K.C., Siriwardena A.K., Ross J.A. Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1 receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis. Surgery. 129:2001;633-640
47. Mayer J., Rau B., Gansauge F., Beger H.G. Inflammatory mediators in human acute pancreatitis: clinical and pathophysiological implications. Gut. 47:2000;546-552
48. Galloway S.W., Kingsnorth A.N. Reduction in circulating levels of CD4-positive lymphocytes in acute pancreatitis: relationship to endotoxin, interleukin-6, and disease severity. Br J Surg. 81:1994;312
49. Pezzilli R., Billi P., Miniero R., Fiocchi M., Cappelletti O., Morselli-Labate A.M., Barakat B., Sprovieri G., Miglioli M. Serum interleukin-6, interleukin-8, and β 2-microglobulin in early assessment of severity of acute pancreatitis. Comparison with serum C-reactive protein. Dig Dis Sci. 40:1995;2341-2348
50. Inagaki T., Hoshino M., Hayakawa T., Ohara H., Yamada T., Yamada H., Iida M., Nakazawa T., Ogasawara T., Uchida A., Hasegawa C., Miyaji M., Takeuchi T. Interleukin-6 is a useful marker for early prediction of the severity of acute pancreatitis. Pancreas. 14:1997;1-8
51. Cuzzocrea S., Mazzon E., Dugo L., Centorrino T., Ciccolo A., McDonald M.C., de Sarro A., Caputi A.P., Thiemermann C. Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice. Cytokine. 18:2002;274-285
52. MacKenzie A., Wilson H.L., Kiss-Toth E., Dower S.K., North R.A., Surprenant A. Rapid secretion of interleukin-1β by microvesicle shedding. Immunity. 15:2001;825-835
53. Mifflin R.C., Saada J.I., Di Mari J.F., Adegboyega P.A., Valentich J.D., Powell D.W. Regulation of COX-2 expression in human intestinal myofibroblasts: mechanisms of IL-1-mediated induction. Am J Physiol Cell Physiol. 282:2002;C824-C834
54. Yan Z., Subbaramaiah K., Camilli T., Zhang F., Tanabe T., McCaffrey T.A., Dannenberg A.J., Weksler B.B. Benzo[a]pyrene induces the transcription of cyclooxygenase-2 in vascular smooth muscle cells. Evidence for the involvement of extracellular signal-regulated kinase and NF-κB. J Biol Chem. 275:2000;4949-4955
55. Liu S.F., Ye X., Malik A.B. Inhibition of NF-κB activation by pyrrolidine dithiocarbamate prevents in vivo expression of proinflammatory genes. Circulation. 100:1999;1330-1337
56. D'Acquisto F., Iuvone T., Rombola L., Sautebin L., Di Rosa M., Carnuccio R. Involvement of NF-κB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages. FEBS Lett. 418:1997;175-178