Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 283, Issue 5 46-5, 2002, Pages

  Song, Albert M ^a   Bhagat, Lakshmi ^a   Singh, Vijay P ^a   Van Acker, Gijs G D ^a   Steer, Michael L ^a   Saluja, Ashok K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cerulein; Heat shock protein 70; Inducible nitric oxide synthase; Myeloperoxidase; Neutrophil; Proinflammatory; Prostaglandin; Trypsin

Indexed keywords

AMYLASE; CERULETIDE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; LACTATE DEHYDROGENASE; TRYPSIN INHIBITOR;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; GENE DELETION; INFLAMMATION; LUNG INJURY; LUNG LAVAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

EID: 0036839741     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00370.2001     Document Type: Article

References (41)

1. Agro A, Langdon C, Smith F, and Richards CD. Prostaglandin E2 enhances interleukin 8 (IL-8) and IL-6 but inhibits GMCSF production by IL-1 stimulated human synovial fibroblasts in vitro. J Rheumatol 23: 862-868, 1996.
2. Al-Mufti RA, Williamson RC, and Mathie RT. Increased nitric oxide activity in a rat model of acute pancreatitis. Gut 43: 564-570, 1998.
3. Amador E, Dorman LE, and Wacker WEC. Serum lactic dehydrogenase: an analytical assessment of current assays. Clin Chem 9: 391, 1936.
4. Bhagat L, Singh VP, Song AM, van Acker GJ, Agrawal S, Steer ML, and Saluja AK. Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats. Gastroenterology 122: 156-165, 2002.
5. Bhatia M, Saluja AK, Hofbauer B, Frossard JL, Lee HS, Castagliuolo I, Wang CC, Gerard N, Pothoulakis C, and Steer ML. Role of substance P and the neurokinin I receptor in acute pancreatitis and pancreatitis-associated lung injury. Proc Natl Acad Sci USA 95: 4760-4765, 1998.
6. Bhatia M, Saluja AK, Singh VP, Frossard JL, Lee HS, Bhagat L, Gerard C, and Steer ML. Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol 280: G974-G978, 2001.
7. Bishop-Bailey D, Burke-Gaffney A, Hellewell PG, Pepper JR, and Mitchell JA. Cyclo-oxygenase-2 regulates inducible ICAM-1 and VCAM-1 expression in human vascular smooth muscle cells. Biochem Biophys Res Commun 249: 44-47, 1998.
8. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
9. Crofford LJ, Wilder RL, Ristimaki AP, Sano H, Remmers EF, Epps HR, and Hla T. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J Clin Invest 93: 1095-1101, 1994.
10. De Gregorio R, Iniguez MA, Fresno M, and Alemany S. Cot kinase induces cyclooxygenase-2 expression in T cells through activation of the nuclear factor of activated T cells. J Biol Chem 276:27003-27009, 2001.
11. Dinchuk JE, Car BD, Focht RJ, Johnston JJ, Jaffee BD, Covington MB, Contel NR, Eng VM, Collins RJ, Czerniak PM, Gorry SA, and Trzaskos JM. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 378: 406-409, 1995.
12. Dyer RB and Herzog NK. Immunodepletion EMSA: a novel method to identify proteins in a protein-DNA complex. Nucleic Acids Res 23: 3345-3346, 1995.
13. Ethridge RT, Chung DH, Ehlers RA, Rajaraman B, and Evers BM. Cyclooxygenase (COX-2) gene disruption markedly attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury (Abstract). Gastroenterology 118: A166, 2000.
14. Ethridge RT, Hellmich MR, DuBois RN, and Evers BM. Inhibition of heat-shock protein 70 induction in intestinal cells overexpressing cyclooxygenase 2. Gastroenterology 115: 1454-1463, 1998.
15. Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, and Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47: 55-59, 1994.
16. Gilroy DW, Colville-Nash PR, Willis D, Chivers J, Paul-Clark MJ, and Willoughby DA. Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med 5: 698-701, 1999.
17. Gukovsky I, Gukovskaya AS, Blinman TA, Zaninovic V, and Pandol SJ. Early NF-κB activation is associated with hormone-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol 275: G1402-G1414, 1998.
18. Haqqani AS, Sandhu JK, and Birnboim HC. A myeloperoxidase-specific assay based upon bromide-dependent chemiluminescence of luminol. Anal Biochem 273: 126-132, 1999.
19. Hendel J and Nielsen OH. Expression of cyclooxygenase-2 mRNA in active inflammatory bowel disease. Am J Gastroenterol 92:1170-1173, 1997.
20. Hietaranta AJ, Saluja AK, Bhagat L, Singh VP, Song AM, and Steer ML. Relationship between NF-κB and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation. Biochem Biophys Res Commun 280: 388-395, 2001.
21. Hla T and Neilson K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci USA 89: 7384-7388, 1992.
22. Hofbauer B, Saluja AK, Lerch MM, Bhagat L, Bhatia M, Lee HS, Frossard JL, Adler G, and Steer ML. Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. Am J Physiol Gastrointest Liver Physiol 275: G352-G362, 1998.
23. Huang ZF, Massey JB, and Via DP. Differential regulation of cyclooxygenase-2 (COX-2) mRNA stability by interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) in human in vitro differentiated macrophages. Biochem Pharmacol 59: 187-194, 2000.
24. Iniguez MA, Punzon C, and Fresno M. Induction of cyclooxygenase-2 on activated T lymphocytes: regulation of T cell activation by cyclooxygenase-2 inhibitors. J Immunol 163: 111-119, 1999.
25. Jaworek J, Bonior J, Tomaszewska R, Jachimczak B, Kot M, Bielanski W, Pawlik WW, Sendur R, Stachura J, Konturek PC, Konturek SJ. Involvement of cyclooxygenase-derived prostaglandin E2 and nitric oxide in the protection of rat pancreas afforded by low dose of lipopolysaccharide. J Physiol Pharmacol 52: 107-126, 2001.
26. Kawabata S, Miura T, Morita T, Kato H, Fujikawa K, Iwanaga S, Takada K, Kimura T, and Sakakibara S. Highly sensitive peptide-4-methylcoumaryl-7-amide substrates for blood-clotting proteases and trypsin. Eur J Biochem 172: 17-25, 1988.
27. Kruger B, Weber IA, Albrecht E, Mooren FC, and Lerch MM. Effect of hyperthermia on premature intracellular trypsinogen activation in the exocrine pancreas. Biochem Biophys Res Commun Commun 282: 159-165, 2001.
28. Labarca C and Paigen K. A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102: 344-352, 1980.
29. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
30. Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H, Liou S, Simmons D, and Hwang D. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 267: 25934-25938, 1992.
31. O'Neill GP and Ford-Hutchinson AW. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 330: 156-160, 1993.
32. Paik JH, Ju JH, Lee JY, Boudreau MD, and Hwang DH. Two opposing effects of nonsteroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. J Biol Chem 275: 28173-28179, 2000.
33. Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM, Rogers RS, Rogier DJ, Yu SS, Anderson GD, Burton EG, Cogburn JN, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Veenhuizen AW, Zhang YY, and Isakson PC. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide (SC-58635, celecoxib). J Med Chem 40: 1347-1365, 1997.
34. Pierre KJ, Tung KK, and Nadj H. A new enzymatic kinetic method for the determination of alpha amylase. Clin Chem 22: 1219, 1976.
35. Seibert K and Masferrer JL. Role of inducible cyclooxygenase (COX-2) in inflammation. Receptor 4: 17-23, 1994.
36. Sousa A, Pfister R, Christie PE, Lane SJ, Nasser SM, Schmitz-Schumann M, and Lee TH. Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma. Thorax 52: 940-945, 1997.
37. Steer ML. Etiology and pathophysiology of acute pancreatitis. In: The Pancreas: Biology, Pathophysiology, and Disease, edited by Go VLV, Dimagno EP, Gardner JD, Lebenthal E, Reber HA, and Scheele GA. New York: Raven, 1993, p. 581-592.
38. Steinle AU, Weidenbach H, Wagner M, Adler G, and Schmid RM. NF-κB/Rel activation in cerulein pancreatitis. Gastroenterology 116: 420-430, 1999.
39. Towbin H, Staehelin T, and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354, 1979.
40. Tsukahara Y, Horita Y, Anan K, Morisaki T, Tanaka M, and Torisu M. Role of nitric oxide derived from alveolar macrophages in the early phase of acute pancreatitis. J Surg Res 66: 43-50, 1996.
41. Zabel-Langhennig A, Holler B, Engeland K, and Mossner J. Cyclooxygenase-2 transcription is stimulated and amylase secretion is inhibited in pancreatic acinar cells after induction of acute pancreatitis. Biochem Biophys Res Commun 265: 545-549, 1999.