-
1
-
-
0036199911
-
High-dose vitamins stimulate variant enzymes with decreased coenzyme-binding affinity (increased Km): Relevance to genetic disease and polymorphisms
-
B. N. Ames, I. Elson-Schwab and E.A. Silver, High-dose vitamins stimulate variant enzymes with decreased coenzyme-binding affinity (increased Km): relevance to genetic disease and polymorphisms, Am. J. Clin. Nutr. 75 (2002), 616-658.
-
(2002)
Am. J. Clin. Nutr.
, vol.75
, pp. 616-658
-
-
Ames, B.N.1
Elson-Schwab, I.2
Silver, E.A.3
-
2
-
-
0035930604
-
Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: Relevance to aging
-
H. Atamna, J. Liu and B.N. Ames, Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: Relevance to aging, J. Biol. Chem. 276 (2001), 48410-48416.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 48410-48416
-
-
Atamna, H.1
Liu, J.2
Ames, B.N.3
-
3
-
-
0037082142
-
The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age
-
H. Atamna, P.W. Walter and B.N. Ames, The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age, Arch. Biochem. Biophys. 397 (2002), 345-353.
-
(2002)
Arch. Biochem. Biophys.
, vol.397
, pp. 345-353
-
-
Atamna, H.1
Walter, P.W.2
Ames, B.N.3
-
4
-
-
0037069320
-
Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging
-
H. Atamna, D.W. Killilea, A.N. Killilea and B.N. Ames, Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging, Proc Natl Acad Sci USA 99 (2002), 14807-14812.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14807-14812
-
-
Atamna, H.1
Killilea, D.W.2
Killilea, A.N.3
Ames, B.N.4
-
5
-
-
0032413244
-
Mitochondrial aging: Open questions
-
K.B. Beckman and B.N. Ames, Mitochondrial aging: open questions, Ann. N. Y. Acad. Sci. 854 (1998), 118-127.
-
(1998)
Ann. N. Y. Acad. Sci.
, vol.854
, pp. 118-127
-
-
Beckman, K.B.1
Ames, B.N.2
-
6
-
-
0031916984
-
The free radical theory of aging matures
-
K.B. Beckman and B.N. Ames, The free radical theory of aging matures, Physiol. Rev. 78 (1998), 547-581.
-
(1998)
Physiol. Rev.
, vol.78
, pp. 547-581
-
-
Beckman, K.B.1
Ames, B.N.2
-
7
-
-
0034931350
-
Micro-nutrient supplementation and the intelligence of children
-
D. Benton, Micro-nutrient supplementation and the intelligence of children, Neurosci Biobehav Rev 25 (2001), 297-309.
-
(2001)
Neurosci. Biobehav. Rev.
, vol.25
, pp. 297-309
-
-
Benton, D.1
-
8
-
-
1042298987
-
Pantothenate is required in Neurospora crassa for assembly of subunit peptides of cytochrome c oxidase and ATPase/ATP synthase
-
R. Brambl and N. Plesofsky-Vig, Pantothenate is required in Neurospora crassa for assembly of subunit peptides of cytochrome c oxidase and ATPase/ATP synthase, Proc Natl Acad Sci USA 83 (1986), 3644-3648.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 3644-3648
-
-
Brambl, R.1
Plesofsky-Vig, N.2
-
9
-
-
0032482999
-
Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity
-
T.M. Hagen, R.T. Ingersoll, C.M. Wehr, J. Lykkesfeldt, V. Vinarsky, J.C. Bartholomew, M.-H. Song and B.N. Ames, Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity, Proc. Natl. Acad. Sci. USA 95 (1998), 9562-9566.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9562-9566
-
-
Hagen, T.M.1
Ingersoll, R.T.2
Wehr, C.M.3
Lykkesfeldt, J.4
Vinarsky, V.5
Bartholomew, J.C.6
Song, M.-H.7
Ames, B.N.8
-
10
-
-
0032423379
-
Mitochondrial decay in aging. Reversal through dietary supplementation of acetyl-L-carnitine and N-tert-butyl-a-phenylnitrone
-
T.M. Hagen, C.M. Wehr and B.N. Ames, Mitochondrial decay in aging. Reversal through dietary supplementation of acetyl-L-carnitine and N-tert-butyl-a-phenylnitrone, Ann. N. Y. Acad. Sci. 854 (1998), 214-223.
-
(1998)
Ann. N. Y. Acad. Sci.
, vol.854
, pp. 214-223
-
-
Hagen, T.M.1
Wehr, C.M.2
Ames, B.N.3
-
11
-
-
0033042929
-
(R)-a-Lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate
-
T.M. Hagen, R.T. Ingersoll, J. Liu, J. Lykkesfeldt, C.M. Wehr, V. Vinarsky, J.C. Bartholomew and B.N. Ames, (R)-a-Lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate, FASEB J 13 (1999), 411-418.
-
(1999)
FASEB J.
, vol.13
, pp. 411-418
-
-
Hagen, T.M.1
Ingersoll, R.T.2
Liu, J.3
Lykkesfeldt, J.4
Wehr, C.M.5
Vinarsky, V.6
Bartholomew, J.C.7
Ames, B.N.8
-
12
-
-
0030915483
-
Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase
-
T.M. Hagen, D.L. Yowe, J.C. Bartholomew, C.M. Wehr, K.L. Do, J.-Y. Park and B.N. Ames, Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase, Proc. Natl. Acad. Sci. USA. 94 (1997), 3064-3069.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 3064-3069
-
-
Hagen, T.M.1
Yowe, D.L.2
Bartholomew, J.C.3
Wehr, C.M.4
Do, K.L.5
Park, J.-Y.6
Ames, B.N.7
-
13
-
-
0033743950
-
(R)-a-Lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo
-
T.M. Hagen, V. Vinarsky, C.M. Wehr and B.N. Ames, (R)-a-Lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo, Antiox. Redox Signal. 2 (2000), 473-483.
-
(2000)
Antiox. Redox Signal.
, vol.2
, pp. 473-483
-
-
Hagen, T.M.1
Vinarsky, V.2
Wehr, C.M.3
Ames, B.N.4
-
14
-
-
0037133304
-
Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress
-
T.M. Hagen, J. Liu, J. Lykkesfeldt, C.M. Wehr, R.T. Ingersoll, V. Vinarsky, J.C. Bartholomew and B.N. Ames, Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress, Proc. Natl. Acad. Sci. USA. 99 (2002), 1870-1875.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 1870-1875
-
-
Hagen, T.M.1
Liu, J.2
Lykkesfeldt, J.3
Wehr, C.M.4
Ingersoll, R.T.5
Vinarsky, V.6
Bartholomew, J.C.7
Ames, B.N.8
-
15
-
-
0020516814
-
Free radical theory of aging: Consequences of mitochondrial aging
-
D. Harman, Free radical theory of aging: consequences of mitochondrial aging, Age 6 (1983), 86-94.
-
(1983)
Age
, vol.6
, pp. 86-94
-
-
Harman, D.1
-
16
-
-
0031889780
-
DNA oxidation matters: The HPLC-EC assay of 8-oxo-deoxyguanosine and 8-oxo-guanine
-
H.J. Helbock, K.B. Beckman, M.K. Shigenaga, P. Walter, A.A. Woodall, H.C. Yeo and B.N. Ames, DNA oxidation matters: The HPLC-EC assay of 8-oxo-deoxyguanosine and 8-oxo-guanine, Proc. Natl. Acad. Sci. USA 95 (1998), 288-293.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 288-293
-
-
Helbock, H.J.1
Beckman, K.B.2
Shigenaga, M.K.3
Walter, P.4
Woodall, A.A.5
Yeo, H.C.6
Ames, B.N.7
-
17
-
-
0037168653
-
Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkB, and AP1 DNA-binding, and affects DNA repair in a rat glioma cell line
-
E. Ho and B.N. Ames, Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkB, and AP1 DNA-binding, and affects DNA repair in a rat glioma cell line, Proc. Natl. Acad. Sci. USA 99 (2002), 16770-16775.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 16770-16775
-
-
Ho, E.1
Ames, B.N.2
-
18
-
-
0038720319
-
Zinc deficiency induces oxidative DNA damage and increases P53 expression in human lung fibroblasts
-
E. Ho, C. Courtemanche and B.N. Ames, Zinc deficiency induces oxidative DNA damage and increases P53 expression in human lung fibroblasts, J. Nutr. 133 (2003), 2543-2548.
-
(2003)
J. Nutr.
, vol.133
, pp. 2543-2548
-
-
Ho, E.1
Courtemanche, C.2
Ames, B.N.3
-
19
-
-
0019248728
-
Identification of porphyrin present in apo-cytochrome C oxidase of copper-deficient yeast cells
-
E. Keyhani and J. Keyhani, Identification of porphyrin present in apo-cytochrome C oxidase of copper-deficient yeast cells, Biochim. Biophys. Acta 633 (1980), 211-227.
-
(1980)
Biochim. Biophys. Acta
, vol.633
, pp. 211-227
-
-
Keyhani, E.1
Keyhani, J.2
-
20
-
-
0037133319
-
Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-a-lipoic acid
-
J. Liu, D. Killilea and B.N. Ames, Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-a-lipoic acid, Proc. Natl. Acad. Sci. USA 99 (2002), 1876-1881.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 1876-1881
-
-
Liu, J.1
Killilea, D.2
Ames, B.N.3
-
21
-
-
0037133283
-
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-carnitine and/or R-a-lipoic acid
-
J. Liu, E. Head, A.M. Gharib, W. Yuan, R.T. Ingersoll, T.M. Hagen, C.W. Cotman and B.N. Ames, Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-a-lipoic acid, Proc. Natl. Acad. Sci. USA 99 (2002), 2356-2361.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 2356-2361
-
-
Liu, J.1
Head, E.2
Gharib, A.M.3
Yuan, W.4
Ingersoll, R.T.5
Hagen, T.M.6
Cotman, C.W.7
Ames, B.N.8
-
22
-
-
0031682205
-
Age-associated decline in ascorbic acid concentration, recycling and biosynthesis in rat hepatocytes - Reversal with (R)-a-Lipoic acid supplementation
-
J. Lykkesfeldt, T.M. Hagen, V. Vinarsky and B.N. Ames, Age-associated decline in ascorbic acid concentration, recycling and biosynthesis in rat hepatocytes - reversal with (R)-a-Lipoic acid supplementation, FASEB J 12 (1998), 1183-1189.
-
(1998)
FASEB J.
, vol.12
, pp. 1183-1189
-
-
Lykkesfeldt, J.1
Hagen, T.M.2
Vinarsky, V.3
Ames, B.N.4
-
23
-
-
0021329156
-
A two-step hypothesis on the mechanisms of in vitro cell aging: Cell differentiation followed by intrinsic mitochondrial mutagenesis
-
J. Miquel and J.E. Fleming, A two-step hypothesis on the mechanisms of in vitro cell aging: cell differentiation followed by intrinsic mitochondrial mutagenesis, Exp. Gerontol. 19 (1998), 31-36.
-
(1998)
Exp. Gerontol.
, vol.19
, pp. 31-36
-
-
Miquel, J.1
Fleming, J.E.2
-
24
-
-
0036154636
-
Marginal biotin deficiency during normal pregnancy
-
D.M. Mock, J.G. Quirk and N.I. Mock, Marginal biotin deficiency during normal pregnancy, Am J. Clin. Nutr. 75 (2002), 295-299.
-
(2002)
Am J. Clin. Nutr.
, vol.75
, pp. 295-299
-
-
Mock, D.M.1
Quirk, J.G.2
Mock, N.I.3
-
25
-
-
0036828376
-
Indicators of marginal biotin deficiency and repletion in humans: Validation of 3-hydroxyisovaleric acid excretion and a leucine challenge
-
D.M. Mock, C.L. Henrich, N. Carnell and N.I. Mock, Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge, Am. J. Clin. Nutr. 76 (2002), 1061-1068.
-
(2002)
Am. J. Clin. Nutr.
, vol.76
, pp. 1061-1068
-
-
Mock, D.M.1
Henrich, C.L.2
Carnell, N.3
Mock, N.I.4
-
27
-
-
0034653564
-
Spontaneous porphyria of the Long-evans cinnamon rat: An animal model of Wilson's disease
-
K. Nakayama, A. Takasawa, I. Terai, T. Okui, T. Ohyama and M. Tamura, Spontaneous porphyria of the Long-evans cinnamon rat: an animal model of Wilson's disease, Arch. Biochem. Biophys. 375 (2000), 240-250.
-
(2000)
Arch. Biochem. Biophys.
, vol.375
, pp. 240-250
-
-
Nakayama, K.1
Takasawa, A.2
Terai, I.3
Okui, T.4
Ohyama, T.5
Tamura, M.6
-
29
-
-
0031791859
-
Decrease of cytochrome c oxidase protein in heart mitochondria of copper-deficient rats
-
L. Rossi, G. Lippe, E. Marchese, A. De Martino, I. Mavelli, G. Rotilio and M.R. Ciriolo, Decrease of cytochrome c oxidase protein in heart mitochondria of copper-deficient rats, Biometals 11 (1998), 207-212.
-
(1998)
Biometals
, vol.11
, pp. 207-212
-
-
Rossi, L.1
Lippe, G.2
Marchese, E.3
De Martino, A.4
Mavelli, I.5
Rotilio, G.6
Ciriolo, M.R.7
-
31
-
-
0015501429
-
Soluble - Aminolevulinic acid synthetase of rat liver. II. Studies related to the mechanism of enzyme action and hemin inhibition
-
P.L. Scholnick, L.E. Hammaker and H.S. Marver, Soluble - aminolevulinic acid synthetase of rat liver. II. Studies related to the mechanism of enzyme action and hemin inhibition, J. Biol. Chem. 247 (1972), 4132-4137.
-
(1972)
J. Biol. Chem.
, vol.247
, pp. 4132-4137
-
-
Scholnick, P.L.1
Hammaker, L.E.2
Marver, H.S.3
-
33
-
-
0023654636
-
Cytochrome c oxidase is a three-copper, two-heme-A protein
-
G.C. Steffens, R. Biewald and G. Buse, Cytochrome c oxidase is a three-copper, two-heme-A protein, Eur. J. Biochem. 164 (1987), 295-300.
-
(1987)
Eur. J. Biochem.
, vol.164
, pp. 295-300
-
-
Steffens, G.C.1
Biewald, R.2
Buse, G.3
-
34
-
-
0036184842
-
Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age
-
T. Tamura, R.L. Goldenberg, J. Hou, K.E. Johnston, S.P. Cliver, S.L. Ramey and K.G. Nelson, Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age, J. Pediatr. 140 (2002), 165-170.
-
(2002)
J. Pediatr.
, vol.140
, pp. 165-170
-
-
Tamura, T.1
Goldenberg, R.L.2
Hou, J.3
Johnston, K.E.4
Cliver, S.P.5
Ramey, S.L.6
Nelson, K.G.7
-
35
-
-
0035179428
-
Dietary intake, dietary patterns, and changes with age: An epidemiological perspective
-
P. Wakimoto and G. Block, Dietary intake, dietary patterns, and changes with age: an epidemiological perspective, J. Gerontol. A Biol. Sci. Med. Sci. 56 (2001), 65-80.
-
(2001)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.56
, pp. 65-80
-
-
Wakimoto, P.1
Block, G.2
-
36
-
-
0037133219
-
Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats
-
P.W. Walter, M.D. Knutson, A. Paler-Martinez, S. Lee, Y. Xu, F.E. Viteri and B.N. Ames, Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats, Proc. Natl. Acad Sci. USA 99 (2002), 2264-2269.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 2264-2269
-
-
Walter, P.W.1
Knutson, M.D.2
Paler-Martinez, A.3
Lee, S.4
Xu, Y.5
Viteri, F.E.6
Ames, B.N.7
-
37
-
-
0021929918
-
The effect of iron substrate on mitochondrial haem synthesis in copper deficiency
-
D.M. Williams, F.S. Kennedy and B.G. Green, The effect of iron substrate on mitochondrial haem synthesis in copper deficiency, Br. J. Nutr. 53 (1985), 131-136.
-
(1985)
Br. J. Nutr.
, vol.53
, pp. 131-136
-
-
Williams, D.M.1
Kennedy, F.S.2
Green, B.G.3
|