Molecular dynamics simulation of a high-affinity antibody-protein complex: The binding site is a mosaic of locally flexible and preorganized rigid regions

Cell Biochemistry and Biophysics

Volumn 43, Issue 2, 2005, Pages 253-273

  Sinha, Neeti ^a   Smith Gill, Sandra J ^b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Binding affinity; Flexibility; Protein protein interactions; Structure function relationship

Indexed keywords

ANTIBODY; HEN EGG LYSOZYME; LYSOZYME;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ELASTICITY; IMMUNOLOGY; MOTION; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ANTIBODIES; ANTIGEN-ANTIBODY COMPLEX; COMPUTER SIMULATION; ELASTICITY; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; MOTION; MURAMIDASE; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23244468302     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1385/CBB:43:2:253     Document Type: Article

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