Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 17, 2005, Pages 3870-3873

  Han, Xiaojun ^a   Michne, Jodi A ^b   Pin, Sokhom S ^a   Burris, Kevin D ^c   Balanda, Lynn A ^a   Fung, Lawrence K ^d   Fiedler, Tracey ^a   Browman, Kaitlin E ^e   Taber, Matthew T ^a   Zhang, Jie ^f   Dubowchik, Gene M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b ASTRAZENECA   (United Kingdom)

^c Palatin Technologies   (United States)

^d NEUROGEN CORPORATION   (United States)

^e ABBOTT LABORATORIES   (United States)

^f SANOFI   (France)

Author keywords

Anxiolytic activity; Corticotropin releasing factor 1 receptor antagonists; Mouse canopy model; SAR

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; IMIDAZOLE DERIVATIVE; RECEPTOR BLOCKING AGENT;

ANIMAL MODEL; ANXIETY; ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BLOOD-BRAIN BARRIER; CORTICOTROPIN-RELEASING HORMONE; HUMANS; IMIDAZOLES; MICE; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23244464576     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.117     Document Type: Article

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