Scrambling of the amino acids within the transmembrane domain of Vpu results in a simian-human immunodeficiency virus (SHIVTM) that is less pathogenic for pig-tailed macaques

Virology

Volumn 339, Issue 1, 2005, Pages 56-69

  Hout, David R ^a   Gomez, Melissa L ^a   Pacyniak, Erik ^a   Gomez, Lisa M ^a   Inbody, Sarah H ^a   Mulcahy, Ellyn R ^a   Culley, Nathan ^b   Pinson, David M ^a   Powers, Michael F ^c   Wong, Scott W ^c   Stephens, Edward B ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

HIV 1; Pathogenesis; SHIV; Transmembrane domain; Vpu

Indexed keywords

AMINO ACID; CD4 ANTIGEN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; ION CHANNEL; MEMBRANE PROTEIN; VPU PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; CELL LOSS; CELL SURFACE; CELLULAR DISTRIBUTION; DOWN REGULATION; GENETIC ANALYSIS; HYDROPHOBICITY; INOCULATION; LYMPHOID TISSUE; MACACA; MOLECULAR CLONING; NONHUMAN; PATHOGENESIS; PATHOGENICITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SEQUENCE ANALYSIS; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE; VIRUS INFECTION; VIRUS LOAD;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL MEMBRANE; DOWN-REGULATION; GENE PRODUCTS, VPU; HIV-1; HUMANS; LYMPH NODES; MACACA NEMESTRINA; PROTEIN STRUCTURE, TERTIARY; REASSORTANT VIRUSES; SIMIAN IMMUNODEFICIENCY VIRUS; VIRULENCE; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA; MACACA NEMESTRINA; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 23244439179     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virol.2005.04.038     Document Type: Article

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