Ion channels formed by HIV-1 Vpu: A modelling and simulation study

FEBS Letters

Volumn 405, Issue 3, 1997, Pages 299-304

  Grice, A L ^a   Kerr, I D ^a   Sansom, M S P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Conductance; HIV 1; Ion channel; Molecular dynamics; Vpu

Indexed keywords

ION CHANNEL; MEMBRANE PROTEIN;

ARTICLE; CHANNEL GATING; COMPUTER SIMULATION; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN STRUCTURE; THERMODYNAMICS;

AMINO ACID SEQUENCE; COMPUTER SIMULATION; GENE PRODUCTS, VPU; HELIX-LOOP-HELIX MOTIFS; HIV-1; INTRACELLULAR MEMBRANES; ION CHANNELS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; THERMODYNAMICS; WATER;

EID: 0030891182     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00198-1     Document Type: Article

References (38)

1. Maldarelli, F., Chen, M.Y., Willey, R.L. and Strebel, K. (1993) J. Virol. 67, 5056-5061.
2. Federau, T., Schubert, U., Flossdorf, J,. Henklein, P., Schomburg, D. and Wray, V. (1996) Int. J. Pept. Prot. Res. 47, 297-310.
3. Henklein, P., Schubert, U., Kunert, O., Klabunde, S., Wray, V., Kloppel, K.D., Kiess, M., Porstmann, T. and Schomberg, D. (1993) Peptide Res. 6, 79-87.
4. Schubert, U., Bour, S., Ferrer-Montiel, A.V., Montal, M., Maldarelli, F. and Strebel, K. (1996) J. Virol. 70, 809-819.
5. Schubert, U., Henklein, P., Bour, S., Ferrer-Montiel, A.V., Oblatt-Montal, M., Montal, M. and Strebel, K. (1995) AIDS Res. Human Retrov. 11, S114.
6. Holsinger, L.J., Nichani, D., Pinto, L.H. and Lamb, R.A. (1994) J. Virol. 68, 1551-1563.
7. Ewart, G.D., Sutherland, T., Gage, P.W. and Cox, G.B. (1996) J. Virol. 70, 7108-7115.
8. Schubert, U., Ferrer-Montiel, A.V., Oblatt-Montal, M., Henklein, P., Strebel, K. and Montal, M. (1996) FEBS Lett. 398, 12-18.
9. Oiki, S., Madison, V. and Montal, M. (1990) Proteins Struct. Funct. Genet. 8, 226-236.
10. Sansom, M.S.P., Kerr, I.D. and Mellor, I.R. (1991) Eur. Biophys. J. 20, 229-240.
11. Sansom, M.S.P. (1991) Prog. Biophys. Mol. Biol. 55, 139-236.
12. Sansom, M.S.P. (1993) Q. Rev. Biophys. 26, 365-421.
13. Chizhmakov, I.V., Geraghty, F.M., Ogden, D.C., Hayhurst, A., Antoniou, M. and Hay, A.J. (1996) J. Physiol. 494, 329-336.
14. Duff, K.C. and Ashley, R.H. (1992) Virology 190, 485-489.
15. Duff, K.C., Kelly, S.M., Price, N.C. and Bradshaw, J.P. (1992) FEBS Lett. 311, 256-258.
16. Kerr, I.D., Sankararamakrishnan, R., Smart, O.S. and Sansom, M.S.P. (1994) Biophys. J. 67, 1501-1515.
17. Sansom, M.S.P. and Kerr, I.D. (1993) Prot. Eng. 6, 65-74.
18. Sansom, M.S.P. Kerr, I.D., Smith, G.R. and Son, H.S. (1997) Virology (submitted).
19. Sansom, M.S.P. and Kerr, I.D. (1995) Biophys. J. 69, 1334-1343.
20. Smart, O.S., Breed, J., Smith, G.R. and Sansom, M.S.P. (1997) Biophys. J. 25, 139-150.
21. Sansom, M.S.P., Smith, G.R., Smart, O.S. and Smith, S.O. (1997) Prot. Eng. (in press).
22. Brünger, A.T. (1992) in Yale University Press, New Haven, CT.
23. Brooks, B.R., Bruccoleri, R.E., Olafson, B.D., States, D.J., Swaminathan, S. and Karplus, M. (1983) J. Comp. Chem. 4, 187-217.
24. Kraulis, P.J. (1991) J. Appl. Crystallogr. 24, 946-950.
25. Breed, J., Sankararamakrishnan, R., Kerr, I.D. and Sansom, M.S.P. (1996) Biophys. J. 70, 1643-1661.
26. Jorgensen, W.L., Chandresekhar, J., Madura, J.D., Impey, R.W. and Klein, M.L. (1983) J. Chem. Phys. 79, 926-935.
27. Biggin, P.C. and Sansom, M.S.P. (1996) Biophys. Chem. 60, 99-110.
28. Taylor, W.R., Jones, D.T. and Green, N.M. (1994) Proteins Struct. Funct. Genet. 18, 281-294.
29. Deber, C.M. and Goto, N.K. (1996) Nature Struct. Biol. 3, 815-818.
30. Sankararamakrishnan, R., Adcock, C. and Sansom, M.S.P. (1996) Biophys. J. 71, 1659-1671.
31. Chothia, C., Levitt, M. and Richardson, D. (1981) J. Mol. Biol. 145, 215-250.
32. Unwin, N. (1989) Neuron 3, 665-676.
33. Mitton, P. and Sansom, M.S.P. (1996) Eur. Biophys. J. (in press).
34. Gray, T.M. and Matthews, B.M. (1984) J. Mol. Biol. 175, 75-81.
35. Smart, O.S., Goodfellow, J.M. and Wallace, B.A. (1993) Biophys. J. 65, 2455-2460.
36. Kerr, I.D., Doak, D.G., Sankararamakrishnan, R., Breed, J. and Sansom, M.S.P. (1996) Prot. Eng. 9, 161-171.
37. Breed, J., Biggin, P.C., Kerr, I.D., Smart, O.S. and Sansom, M.S.P. (1997) Biochim. Biophys. Acta (in press).
38. Roux, B. and Karplus, M. (1991) Biophys. J. 59, 961-981.