Structure of the 1,4-Bis(2′-deoxyadenosin-N6-yl)-2R,3R- butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide

Biochemistry

Volumn 44, Issue 30, 2005, Pages 10081-10092

  Merritt, W Keither ^a   Nechev, Lubomir V ^a,c   Scholdberg, Tandace A ^a,d   Dean, Stephen M ^a   Kiehna, Sarah E ^a   Chang, Johanna C ^a   Harris, Thomas M ^a   Harris, Constance M ^a   Lloyd, R Stephen ^b   Stone, Michael P ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c ALNYLAM PHARMACEUTICALS   (United States)

^d USDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; BIOCHEMISTRY; BUTADIENE; CARBON; COMPUTER SIMULATION; CROSSLINKING; DNA; ESTERS; GELS; HYDROGEN BONDS; MOLECULAR DYNAMICS; MUTAGENESIS; PROTEINS; SIMULATED ANNEALING; SOLVENTS;

ADENINES; BUTADIENE DIEPOXIDE; OLIGODEOXYNUCLEOTIDE; TORSION ANGLE;

ALCOHOLS;

1,4 BIS(2' DEOXYADENOSIN N 6 YL)BUTANEDIOL; ADENINE DERIVATIVE; BUTADIENE DIEPOXIDE; BUTANEDIOL; CURVED DNA; DNA POLYMERASE; DOUBLE STRANDED DNA; HYDROXYL GROUP; OLIGODEOXYNUCLEOTIDE; SOLVENT; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BASE PAIRING; CODON; CROSS LINKING; DNA HELIX; HUMAN; HYDROGEN BOND; MOLECULAR DYNAMICS; MUTAGENICITY; NUCLEAR OVERHAUSER EFFECT; ONCOGENE N RAS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ALKYLATING AGENTS; BASE PAIRING; BUTADIENES; BUTYLENE GLYCOLS; CODON; CROSS-LINKING REAGENTS; DEOXYADENOSINES; DNA ADDUCTS; EPOXY COMPOUNDS; GENES, RAS; HUMANS; MUTAGENS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID HETERODUPLEXES; OLIGODEOXYRIBONUCLEOTIDES; PROTONS;

EID: 23144465497     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047263g     Document Type: Article

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