The death receptor pathway is not involved in alloreactive T-cell induced mitochondrial membrane permeability

Leukemia and Lymphoma

Volumn 46, Issue 8, 2005, Pages 1207-1216

  Grüllich, Carsten ^a,b   McGoldrick, Suzanne ^a   Zeiser, Robert ^a,c   Finke, Jürgen ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alloreactivity; Apoptosis; Death receptor; Grazyme; Perforin

Indexed keywords

BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 8; CONCANAMYCIN A; DEATH RECEPTOR;

ALLOIMMUNITY; APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CELL CULTURE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; EPSTEIN BARR VIRUS; EXOCYTOSIS; FLOW CYTOMETRY; HLA MATCHING; HUMAN; HUMAN CELL; INCUBATION TIME; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STUDENT T TEST; T LYMPHOCYTE SUBPOPULATION; TUMOR CELL; VIRUS CELL TRANSFORMATION;

ANTIGENS, CD95; APOPTOSIS; CASPASES; CELL LINE, TRANSFORMED; COUMARINS; CYSTEINE PROTEINASE INHIBITORS; CYTOTOXICITY TESTS, IMMUNOLOGIC; HUMANS; INTRACELLULAR MEMBRANES; MACROLIDES; MITOCHONDRIA; OLIGOPEPTIDES; PERMEABILITY; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 23144451416     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190500138435     Document Type: Article

References (44)

1. Penn I, Hammond W, Brettschneider I, Starzl TE. Malignant lymphomas in transplantation patients. Transplant Proc 1969;1(1):106-112.
2. Paya CV, Fung JJ, Nalesnik MA, Kieff E, Green M, Gores G, Habermann TM, Wiesner PH, Swinnen JL, Woodle ES, Bromberg JS. Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force and The Mayo Clinic Organized International Consensus Development Meeting. Transplantation 1999;68 (10):1517-1515.
3. Rooney CM, Smith CA, Ng CY, Loftin S, Li C, Krance RA. Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet 1995; 345(8941): 9-13.
4. Berke G. The CTL's kiss of death. Cell 1995;81(1):9-12
5. Henkart PA. Lymphocyte-mediated cytotoxicity: two pathways and multiple effector molecules. Immunity 1994;1(5): 343-348.
6. Kagi D, Vignaux F, Ledermann B, Burki K, Depraetere V, Nagata V. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 1994;265(7):528-532.
7. Schmaltz C, Alpdogan O, Horndasch KJ, Muriglan SJ, Kappel BJ, Teshima T. Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect. Blood 2001; 97(9):2886-2895.
8. Nagata S. Apoptosis by death factor. Cell 1997;88(3):355-365.
9. Smyth MJ, Trapani JA. Granzymes: exogenous proteinases that induce target cell apoptosis. Immunol Today 1995;16(5):202-206.
10. Trapani JA, Jans P, Smyth MJ, Froehlich CJ, Williams EA, Sutton VR. Death Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction. Differ 1998;5(3):488-496.
11. Zamzami N, Kroemer G. Apoptosis: mitochondrial membrane permeabilization - the (w)hole story? Curr Biol 2003;21(2):71-73.
12. Martinou JC, Green DR. Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol 2001;2(1): 63-67.
13. Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M. Tumorcidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nature Med 1999;5(2):157-163.
14. Braun MY, Lowin B, French L, Archa-Obea H, Tschopp J. Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease. J Exp Med 1996;183(1):657-661.
15. Thomas WD, Hersey P. TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in FAS ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells. J Immunol 1998;161(5):2195-2200.
16. Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000;102(3): 33-42.
17. Goldstein JC, Waterhouse NJ, Juin P, Evan GI, Green DR. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nature Cell Biol 2000;2(3):156-162.
18. Desagher S, Martinou JC. Mitochondria as the central control point of apoptosis. Trends Cell Biol 2000;10(3):369-377.
19. Yasukawa M, Ohminami H, Arai J, Kasahara Y, Kasahara Y, Ishida Y, Fujita S. Granule exocytosis, and not the fas/fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humans. Blood 2000;95(7):2352-2355.
20. Scaffidi C, Schmitz I, Zha J, Korsmeyer SJ, Krammer PH, Peter ME. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem 1999; 274(32):22532-22538.
21. Grüllich C, Sullards MC, Fuks Zvi, Merrill AH Jr, Kolesnick R. CD95 (Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis. J Biol Chem 2000;275(12):8650-8656.
22. Beatty PR, Krams SM, Martinez OM. Involvement of IL-10 in the autonomous growth of EBV-transformed B cell lines. J Immunol 1997;158(3):4045-4049.
23. Kroemer G, Reed JC. Mitochondrial control of cell death. Nature Med 2000;6(3):513-519
24. Heiskanen, KM, Bhat MB, Wang HW, Ma JJ, Nieminen AL. Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells. J Biol Chem 1999;274(3): 5654-5658.
25. Bernardi P, Scorrano L, Colonna R, Petronilli V, Di Lisa F. Mitochondria and cell death - Mechanistic aspects and methodological issues. Eur J Biochem 1999;264(2):687-701.
26. Kataoka T, Shinohara N, Takayama H, Takaku K, Kondo S, Yonehara S. Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. J Immunol 1996;156(3):3678-3686.
27. Pepe MS. The Statistical Evaluation of Medical Tests for Classification and Prediction. Oxford: Oxford University Press; 2003, pp. 126-135.
28. Waterhouse NJ, Clarke CJ, Sedelies KA, Teng MW, Trapani JA. Cytotoxic lymphocytes; instigators of dramatic target cell death. Biochem Pharmacol. 2004;68(6):1033-1040.
29. Trapani JA, Sutton VR. Granzyme B: pro-apoptotic, antiviral and antitumor functions. Curr Opin Immunol. 2003; 15(5):533-543.
30. Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW, Thornberry NA. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 1998;273(14):32608-32613.
31. Watanabe T, Sakai Y, Miyawaki S, Shimizu A, Koiwai O, Ohno K. A molecular genetic linkage map of mouse chromosome 19, including the 1pr, Ly-44, and Tdt genes. Biochem Genet 1991;29(3):325-335.
32. Walsh CM, Matloubian M, Liu CC, Ueda R, Kurahara CG, Christensen JL. Immune function in mice lacking the perforin gene. Proc Natl Acad Sci USA 1994;91(6):10854-10858.
33. Smyth MJ, Street SE, Trapani JA. Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. J Immunol. 2003;171(2):515-518.
34. Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME. Apoptosis signaling by death receptors. Eur J Biochem. 1998 Jun 15;254(3):439-459.
35. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994;76(13):969-976.
36. Peter ME, Krammer PH. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 2003;10(9):26-35.
37. Nicholson DW, Thornberry NA. Apoptosis. Life and death decisions. Science 2003;299(8): 214-215.
38. Heibein JA, Goping IS, Barry M, Pinkoski MJ, Shore GC, Green DR. Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax. J Exp Med 2000;192(13):1391-1402.
39. Pardo J, Perez-Galan P, Gamen S, Marzo I, Monleon I, Kaspar AA, Susin SA, Kroemer G, Krensky AM, Naval J, Anel A. A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis. J Immunol 2001;167(3): 1222-1229.
40. Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC. Granzyme B: a natural born killer. Immunol Rev. 2003 Jun;193:31-38.
41. Barnhart BC, Alappat EC, Peter ME. The CD95 typeI/typeII model. Semin Immunol 2003; 15(3):185-193
42. Dirsch VM, Muller IM, Eichhorst ST, Pettit GR, Kamano Y, Inoue M, Xu JP, Ichihara Y, Wanner G, Vollmar AM. Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix. Cancer Res 2003;63(24):8869-8876.
43. Chiriva-Internati M, Du J, Cannon M, Barlogie B, Yi Q. Myeloma-reactive allospecific cytotoxic T lymphocytes lyse target cells via the granule exocytosis pathway. Br J Haematol 2001;112(2):410-420.
44. Porakishvili N, Kardava L, Jewell AP, Yong K, Glennie MJ, Akbar A, Lydyard PM. Cytotoxic CD4 + T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway. Haematologica 2004;89(4):35-443.