Stem cell dysregulation in myelofibrosis with myeloid metaplasia: Current data on growth factor and transcription factor involvement

Seminars in Oncology

Volumn 32, Issue 4, 2005, Pages 373-379

  Martyré, Marie Claire ^a   Le Bousse Kerdilès, Marie Caroline ^b   Demory, Jean Loup ^c   Dupriez, Brigitte ^d   Bordessoule, Dominique ^e   Brière, Jean ^f   Bilhou Nabéra, Chrystèle ^g   Lippert, Eric ^g   Praloran, Vincent ^g  

^a INSTITUT CURIE   (France)

^b HÔPITAL PAUL BROUSSE   (France)

^c Groupement Hospitalier de L'Institut Catholique Facultél Libre de Méldecine de Lille   (France)

^d Service Pharmacie CH dr Schaffner   (France)

^e DUPUYTREN UNIVERSITY HOSPITAL   (France)

^f BEAUJON HOSPITAL   (France)

^g Laboratoire Universitaire d'Hématologie Bordeaux 2   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; TRANSCRIPTION FACTOR;

CELL ACTIVITY; CELL INTERACTION; FIBROGENESIS; HEMATOPOIESIS; HEMATOPOIETIC CELL; HEMATOPOIETIC SYSTEM; HUMAN; MOLECULAR BIOLOGY; MYELOFIBROSIS; MYELOFIBROSIS WITH MYELOID METAPLASIA; MYELOID METAPLASIA; MYELOPROLIFERATIVE DISORDER; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; STROMA CELL;

EID: 23044480090     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2005.04.009     Document Type: Article

References (60)

1. J.T. Reilly Idiopathic myelofibrosis: Pathogenesis, natural history and management Blood Rev 11 1997 233 242
2. R.A. Mesa, C.A. Hanson, V. Rajkumar Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia Blood 96 2000 3376 3380
3. J.C. Wang, H.D. Lang, S. Lichter Cytogenetic studies of bone marrow fibroblasts cultured from patients with myelofibrosis and myeloid metaplasia Br J Haematol 80 1992 184 188
4. A. Tefferi, R.A. Mesa, C.A. Schroeder Ghanson Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia Br J Haematol 113 2001 763 771
5. R.J. Jacobson, A. Salo, P.J. Fialkow Agnogenic myeloid metaplasia: A clonal proliferation of haematopoietic stem cells with secondary myelofibrosis Blood 51 1978 189 194
6. M. Buschle, J.W.G. Janssen, H. Drexler Evidence for pluripotent stem cell origin of idiopathic myelofibrosis: Clonal analysis of a case characterized by a N-ras gene mutation Leukemia 2 1988 658 660
7. A.J. Bench, N.C.P. Cross, B.J.P. Huntly Myeloproliferative disorders Best Pract Res Clin Haematol 14 2001 531 551
8. low cells reflect the persistence of normal primitive hematopoietic progenitors in myeloid metaplasia with myelofibrosis? Blood 102 2003 1551 1552
9. T.L. Reeder, R.J. Bailey, G.W. Dewald Both B and T lymphocytes may be clonally involved in myelofibrosis with myeloid metaplasia Blood 101 2003 1981 1983
10. H. Castro-Malaspina Pathogenesis of myelofibrosis: Role of ineffective megakaryopoiesis and megakaryocyte components P. Berck H. Castro-Malaspina L.R. Wasserman Myelofibrosis and the Biology of Connective Tissue 1984 Liss New York, NY 427 454
11. I. Dokal, L. Jones, M. Deenmamode Allogeneic bone marrow transplantation for primary myelofibrosis Br J Haematol 71 1989 158 160
12. J.A. Hibbin, O.S. Njoku, E. Matutes Myeloid progenitor cells in the circulation of patients with myelofibrosis and other myeloproliferative disorders Br J Haematol 57 1984 495 503
13. P. Porcu, R.S. Neiman, A. Orazi Splenectomy in agnogenic myeloid metaplasia Blood 93 1999 2132 2133
14. M.C. Le Bousse-Kerdilès, M.C. Martyré French INSERM Research Network on Myelofibrosis With Myeloid Metaplasia Myelofibrosis: Pathogenesis of myelofibrosis with myeloid metaplasia Springer Semin Immonopathol 21 2000 450 491
15. + cells in myelofibrosis with myeloid metaplasia Blood 98 2001 3249 3255
16. G. Chikkappa, A.L. Carsten, A.D. Chanana Increased granulocytic, erythrocytic and megakaryocytic progenitors in myelofibrosis with myeloid metaplasia Am J Hematol 4 1978 121 131
17. M.C. Martyré, N. Romquin, M.C. Le Bousse-Kerdilès Transforming growth factor-β and megakaryocytes in the pathogenesis of idiopathic myelofibrosis Br J Haematol 88 1994 9 16
18. M.C. Martyré TGF-β and megakaryocytes in the pathogenesis of myelofibrosis in myeloproliferative disorders Leuk Lymphoma 20 1995 39 44
19. M.C. Martyré, C. Le Bousse-Kerdilès, N. Romquin Elevated levels of basic fibroblast growth factor in megakaryocytes and platelets from patients with idiopathic myelofibrosis Br J Haematol 97 1997 441 448
20. + hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia Blood 88 1996 4534 4546
21. M.C. Martyré, H. Magdelenat, M.C. Bryckaert Increased intraplatelet levels of platelet-derived growth factor and transforming growth factor-β in patients with myelofibrosis with myeloid metaplasia Br J Haematol 77 1991 80 86
22. H.S. Gilbert, V. Praloran, E.R. Stanley Increased CSF-1 (M-CSF) in myeloproliferative disease: Association with myeloid metaplasia and peripheral bone marrow extension Blood 74 1989 1231 1234
23. F. Smadja-Joffe, S. Legras, Y. Li CD44 and hyaluronan binding by human myeloid cells Leuk Lymphoma 21 1996 407 420
24. X.Q. Yan, D. Lacey, D. Hill A model of myelofibrosis and osteomyelosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): Reversal of disease by bone marrow transplantation Blood 88 1996 402 409
25. J.L. Villeval, K. Cohen-Solal, M. Tulliez High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice Blood 90 1997 4369 4383
26. F. Wendling, P. Varlet, M. Charon A retrovirus complex inducing an acute myeloproliferative disorder in adult mice Virology 149 1986 242 246
27. C. Challier, L. Cocault, R. Berthier The cytoplasmic domain of Mpl receptor transduces exclusive signals in embryonic and fetal hematopoietic cells Blood 100 2002 2063 2070
28. K. Carver-Moore, H.E. Broxmeyer, S.M. Luoh Low levels of erythroid and myeloid progenitors in thrombopoietin- and c-mpl-deficient mice Blood 88 1996 803 808
29. A.L. Taksin, J.P. Le Couedic, I. Dusanter-Fourt Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to autocrine stimulation by Mpl-L Blood 93 1999 125 139
30. Cocault L, Le Bousse-Kerdilès C, Flon M, et al: TPO, c-mpl and megakaryocytes in idiopathic myelofibrosis. European Working Group on Myeloproliferative disorders of the European Haematology Association, Rotterdam, the Netherlands, March 12-14, 1998 (abstr)
31. O. Bock, J. Schlue, M. Mengel Thrombopoietin receptor (Mpl) expression by megakaryocytes in myeloproliferative disorders J Pathol 203 2004 609 615
32. A. Moliterno, W. Hankins, J. Spivak Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera N Engl J Med 338 1998 572 580
33. J.C. Wang, C. Chen, L.H. Lou Blood thrombopoietin, IL-6 and IL-11 levels in patients with agnogenic myeloid metaplasia Leukemia 11 1997 1827 1832
34. T. Sittonen, E.R. Savolainen, P. Koistinen Expression of the c-kit proto-oncogene in myeloproliferative disorders and myelodysplasic syndromes Leukemia 8 1994 631 637
35. Y. Nakata, A. Kimura, O. Katoh c-kit point mutation of extracellular domain in patients with myeloproliferative disorders Br J Haematol 91 1995 661 663
36. H.P. Gerber, N. Ferrara The role of VEGF in normal and neoplastic hematopoiesis J Mol Med 81 2003 20 31
37. F. DiRaimondo, M.P. Azzaro, G.A. Palumbo Elevated vascular endothelial growth factor (VEGF) serum levels in idiopathic myelofibrosis Leukemia 15 2001 976 980
38. G. Barosi, R. Vittorio, M. Margherita Spleen neoangiogenesis in patients with myelofibrosis with myeloid metaplasia Br J Haematol 124 2004 618 625
39. D. Brouty-Boyé, C. Doucet, D. Clay Phenotypic diversity in human fibroblasts from myelometaplasic and non-myelometaplasic hematopoietic tissues Int J Cancer 76 1998 767 773
40. + stem cells Int J Cancer 92 2001 484 488
41. + progenitors from patients with myeloid metaplasia with myelofibrosis Clin Immunol 106 2003 201 212
42. F. Cervantes, J.C. Hernandez-Boluda, N. Villamor Assessment of peripheral blood lymphocyte subsets in idiopathic myelofibrosis Eur J Haematol 65 2000 104 108
43. S. Giraudier, H. Chagraoui, E. Komura Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors Blood 100 2002 2932 2940
44. E. Komura, H. Chagraoui, V. Mansat de Mas Spontaneous STAT5 activation induces growth factor independence in idiopathic myelofibrosis: possible relationship with FKBP51 overexpression Exp Hematol 31 2003 622 630
45. C. James, V. Ugo, J.P. Le Couédic A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera Nature 434 2005 1144 1148
46. F. Romero, S. Fischer Structure and function of Vav Cell Signal 8 1996 545 553
47. A. Micouin, V. Steunou, J. Wietzerbin Lack of interferon-alpha-induced tyrosine phosphorylation of Vav proto-oncogene in patients with myelofibrosis with myeloid metaplasia Br J Haematol 110 2000 362 369
48. low mice) Blood 100 2002 1132 1223
49. low mice Blood 98 2003 2438 (abstr)
50. + hematopoietic progenitors from patients with idiopathic myelofibrosis Blood 101 2003 5087 5089
51. Vannucchi AM, Bianchi L, Migliaccio AR, et al: Reduced GATA-1 content in megakaryocytes of patients with idiopathic myelofibrosis. Blood 98:2457, 2003 (abstr)
52. V. Steunou, M.C. Le Bousse-Kerdilès, A. Colin-Micouin Altered transcription of the stem cell leukemia gene in myelofibrosis with myeloid metaplasia Leukemia 10 2003 1998 2006
53. K. Pulford, N. Lecointe, K. Leroy-Viard Expression of TAL-1 proteins in human tissues Blood 85 1995 675 684
54. J.C. Wang, W. Chen, S. Nallusamy Hypermethylation of the P15 INK4b and P16 INK4a in agnogeneic myeloid metaplasia (AMM) and AMM in leukemic transformation Br J Haematol 116 2002 582 586
55. J. Andrieux, J.L. Demory, B. Dupriez Dysregulation and overexpression of HMGA2 in myelofibrosis with myeloid metaplasia Genes Chromosomes Cancer 39 2004 82 87
56. Andrieux J, Demory JL, Dupriez B, et al: HMGA2 is consistently expressed in blood mononuclear cells from patients with myelofibrosis and myeloid metaplasia (MMM). Second International Congress on Myeloproliferative Disease and Myelodysplasic Syndromes, New York, NY, October 16-18, 2003 (abstr 07)
57. A. Tefferi The forgotten myeloproliferative disorder: Myeloid metaplasia Oncologist 8 2003 225 231
58. M.C. Le Bousse-Kerdilès, M.C. Martyré French INSERM Research Network on Idiopathic Myelofibrosis Dual implication of fibrogenic cytokines in the pathogenesis of fibrosis and myeloproliferation in myeloid metaplasia with myelofibrosis Ann Hematol 78 1999 434 444
59. J. Thiele, T. Kuemmel, C. Sander Ultrastructure of the bone marrow tissue in so-called primary (idiopathic) myelofibrosis-osteomyelosclerosis (agnogenic myeloid metaplasia) I. Abnormalities of megakaryopoiesis and thrombocytes J Subsmicrosc Cytol Pathol 23 1991 93 107
60. P. Rameshwar, T.N. Denny, D. Stein Monocyte adhesion in patients with bone marrow fibrosis is required for the production of fibrogenic cytokines Potential role for interleukin-1 and TGF-β J Immunol 153 1994 2819 2830